Lifeboat Foundation

ROS are short lived molecular species containing an unpaired electron which makes them highly reactive as they search for another electron to pair with, and in the process can damage biomolecules such as DNA, proteins and lipids⁵⁴. ROS induced oxidative stress is known to have multiple deleterious effects on host cells⁵⁵. However, we have reported that, paradoxically, when ROS is artificially generated outside the cell in the extracellular spaces of the body, they can have wide ranging therapeutic effects^{18,19,20,26,27}. Admixing R with Cu leads to generation of oxygen radicals by virtue of the ability of R to reduce Cu (II) to Cu (I)^23,25. Oxygen radicals that are generated in the stomach upon oral administration of R–Cu are apparently absorbed to have systemic effects in the form of deactivation/eradication of extracellular cfChPs. We have shown that cfChPs have wide-ranging damaging effects on host cells. For example, cfChPs can readily enter into the healthy cells to damage their DNA, activate inflammatory cytokines and promote apoptosis via the mitochondrial pathway^13,14. Given that 1 × 10⁹–1 × 10¹² cells die in the body every day^56,57, we have hypothesised that repeated and lifelong assault on healthy cells by cfChPs derived from the dying cells may be the underlying cause of ageing^15,16. In support of this hypothesis we show in this article that prolonged oral administration of R–Cu to ageing mice down-regulated multiple biological hallmarks of ageing and neurodegeneration by virtue of its ability to deactivate cfChPs. Our results suggest that R–Cu may qualify as an ideal anti-ageing agent since it has the potential to simultaneously retard or delay the many conditions that are associated with ageing². To be globally applicable, an ideal anti-ageing agent should also be inexpensive and non-toxic—the two criteria that are also met by R–Cu. The latter can be easily administered orally, and both R and Cu are already approved for human use. An illustrated summary of the study design and the mechanisms by which R–Cu generated oxygen radicals eradicate cfChPs from brain micro-environment leading to down-regulation of ageing hallmarks is provided in Fig. 10.

The mechanism(s) by which R–Cu down-regulates the multiple biological hallmarks of ageing and neurodegeneration needs elaboration. Reversal of telomere shortening by R–Cu may suggest that telomere shortening could be a consequence of DNA damage inflicted by cfChPs which shear off telomere ends causing them to shorten. We observed differential effects between female and male mice with respect to telomere abnormalities. R–Cu effects in preventing telomere abnormalities in female mice were statistically significant for all parameters tested, while this was not the case in male mice. The biological explanation for this discrepant finding remains to be determined. Breakage of telomere ends may also help to explain our detection of persistent γ-H2AX signals in telomere regions of brain cells (DNA-SCARS)—an established signature of senescence⁴³. The bare chromosomal ends can fuse with each other to lead to chromosomal instability and aneuploidy⁴⁸, as was detected in our study.

Latest breakthroughs in AI, voice biometrics, and speech recognition are paving the way to the exciting future of intuitive voice interaction with smart technologies!

Researchers at the University of Waterloo in Waterloo, Ontario say they’ve captured the first composite image of something that – although astronomers have talked about it for decades – has been hitherto unseen, and in fact undetected. They say it’s an image of dark matter, a connection point in the great cosmic web in which our universe’s billions of galaxies are thought to be embedded. The Royal Astronomical Society, which published the new work in its peer-reviewed Monthly Notices, said in a statement:

Large Hadron Collider has helped determine the distribution of masses that the Higgs boson can have, a measure known as its width.

Circa 2019 o.o!!!!

A light-based machine could hold the answers.

Circa 2013 face_with_colon_three

Physicists have been chasing antimatter technology for more than 80 years now — driven by the promise of oppositely oriented particles that explode in a burst of energy whenever they make contact with their more common counterpart. If we could tame antimatter, those explosions could be used to power a new generation of technology, from molecular scanners to rocket engines to the so-called “annihilation laser,” a tightly concentrated energy beam fueled by annihilating positrons. But while scientists have seen recent breakthroughs in creating the particles, they still have trouble capturing and containing them.

The first impressions of using the Quest Pro’s virtual screens indicate some impressive results.

A newly discovered type of transferable DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Physicists just reconstructed a 19th-century paradox that seems to violate the second law of thermodynamics (but really doesn’t).