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Researchers from Children’s Hospital of Philadelphia (CHOP) and Princeton University have discovered a novel genetic disorder associated with neurodevelopmental differences. The discovery identified the disorder in 21 families from all over the world. The study “Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish” is published in Science Advances today, April 26.

The as-yet unnamed disorder is the result of a series of rare variants in the MAP4K4 gene, which is involved in many signaling pathways, including the RAS pathway that normal cell growth, and is being investigated as druggable target for multiple disorders.

The researchers had documented several patients with craniofacial and neurodevelopmental issues that indicated a then-unknown genetic cause. They put out an international call for patients who seemed to fit these specific criteria. Ultimately, they were able to identify patients from 36 countries to determine whether there was a genetic variant linking them to their clinical issues.

A Spanish startup has built a sperm-injecting robot that can be controlled using a PlayStation controller. The team successfully used it to fertilize human eggs, eventually resulting in the birth of two healthy babies.

As MIT Technology Review reports, one of the engineers working on the world’s first insemination robot didn’t have all that much experience in the field of fertility medicine — which was where the PlayStation 5 controller came into, well, play.

Using the controller, a student engineer from startup Overture Life [name after descriptor] steered a tiny, mechanized in-vitro fertilization (IVF) needle to deposit single sperm cells into human eggs more than a dozen times.

A team of researchers at the U.S. Department of Energy’s Argonne National Laboratory has developed a new scientific tool called Polybot that combines artificial intelligence with robotics. This tool is set to revolutionize polymer electronics research by speeding up the discovery process of materials with multiple applications, from wearable biomedical devices to better batteries, according to a release.

Polymer electronics are the future of flexible electronics. They are efficient and sustainable, used to monitor health and treat certain diseases, among other things. However, the current methods used to prepare these polymers for electronics can take years of intense labor. To achieve targeted performance, there are an overwhelming number of potential tweaks, from spiking the fabrication recipe with different formulations to varying the processing conditions.

A new study shows that areas of the brain that are responsible for movement are also connected to networks involved in thinking and planning, as well as the control of involuntary bodily actions.

Genetic conditions like Dravet syndrome are hard to tackle with traditional gene therapy. But new approaches are in the works.

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Jetson/YouTube.

Continue reading “Take your commute to new heights under 100k with Jetson’s eVTOL” »

In the realm of computing, information is usually perceived as being represented by a binary system of ones and zeros. However, in our everyday lives, we use a decimal system consisting of ten digits to represent numbers. For instance, the number 9 in binary is represented as 1,001, requiring four digits instead of just one in the decimal system.

Today’s quantum computers have emerged from the binary system, but the physical systems that encode their quantum bits (qubits) have the capability to encode quantum digits (qudits) as well. This was recently demonstrated by a team headed by Martin Ringbauer at the University of Innsbruck’s Department of Experimental Physics. According to experimental physicist Pavel Hrmo at ETH Zurich: “The challenge for qudit-based quantum computers has been to efficiently create entanglement between the high-dimensional information carriers.”

In a study published on April 19, 2023, in the journal Nature Communications.

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Physicists measure and control electron release from metals in the attosecond range.

By superimposing two laser fields of different strengths and frequency, the electron emission of metals can be measured and controlled precisely to a few attoseconds. Physicists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), the University of Rostock and the University of Konstanz have shown that this is the case. The findings could lead to new quantum-mechanical insights and enable electronic circuits that are a million times faster than today.

Continue reading “A Flash of Genius: Taming Electrons With Laser Precision for 1,000,000x Faster Electronics” »

As highlighted in a recent article, the release of ChatGPT in its various guises, along with numerous other generative AI-based technologies, has heralded a flurry of articles, studies, and headlines lauding the often catastrophic impact such technologies will have on jobs and society more broadly.

It’s the kind of simplistic and often doom-laden narrative that so often thrives on social media. As Greg Berman and Aubrey Fox remind us in their recent book Gradual, however, change seldom happens rapidly and almost never happens in such a linear fashion.

The study surveyed executives from 200 large companies and found that while most recognized the importance of new technologies, many were unrealistic about their ability to transform their businesses. The survey revealed that companies that took a more measured and realistic approach to technology adoption tended to be more successful.

Continue reading “We Need Caution When Predicting The Future Of Work” »