Jan 27, 2017
Researchers uncover how brain circuit elicits hunger responses during starvation
Posted by Karen Hurst in categories: biotech/medical, nanotechnology, neuroscience
Could we eventually see a day where we have cell circuitry nanobot pill that eliminates hunger and obesity as replacement to gastric bypasses? Maybe.
The human body responds to starving conditions, such as famine, to promote the chance of survival. It reduces energy expenditure by stopping heat production and promotes feeding behavior. These “hunger responses” are activated by the feeling of hunger in the stomach and are controlled by neuropeptide Y (NPY) signals released by neurons in the hypothalamus. However, how NPY signaling in the hypothalamus elicits the hunger responses has remained unknown.
Sympathetic motor neurons in the medulla oblongata are responsible for heat production by brown adipose tissue (BAT). Researchers centered at Nagoya University have now tested whether the heat-producing neurons respond to the same hypothalamic NPY signals that control hunger responses. They injected NPY into the hypothalamus of rats and tested the effect on heat production. Under normal conditions, blocking inhibitory GABAergic receptors or stimulating excitatory glutamatergic receptors in the sympathetic motor neurons induced heat production in BAT. After NPY injection, stimulating glutamatergic receptors did not produce heat, but inhibiting GABAergic receptors did. The study was recently reported in Cell Metabolism.
ly difficult to maneuver and control once in space, and George Washington University’s plasma thruster technology helps us manage this problem. The thrusters use titanium as a propellant, which is converted into a gas-like plasma to provide propulsion. The plasma then accelerates and expands into a vacuum at high velocities to produce thrust. This thrust helps the craft overcome drag and maintain the small satellite’s orbit. We plan to use the technology as part of our launch system dedicated to micro spacecraft.
