Lifeboat Foundation

Nanotransfection is very useful and could be used as a way to heal oneself on a smartphone in one touch with cell reprogramming and much more like gene transfer.

Tissue nanotransfection (TNT), a cutting-edge technique of in vivo gene therapy, has gained substantial attention in various applications ranging from in vivo tissue reprogramming in regenerative medicine, and wound healing to cancer treatment. This technique harnesses the advancements in the semiconductor processes, facilitating the integration of conventional transdermal gene delivery methods—nanoelectroporation and microneedle technologies. TNT silicon chips have demonstrated considerable promise in reprogramming fibroblast cells of skin in vivo into vascular or neural cells in preclinical studies to assist in the recovery of injured limbs and damaged brain tissue. More recently, the application of TNT chips has been extended to the area of exosomes, which are vital for intracellular communication to track their functionality during the wound healing process.

Human brain organoids represent a remarkable platform for modeling neurological disorders and a promising brain repair approach. However, the effects of physical stimulation on their development and integration remain unclear. Here, we report that low-intensity ultrasound significantly increases neural progenitor cell proliferation and neuronal maturation in cortical organoids. Histological assays and single-cell gene expression analyses reveal that low-intensity ultrasound improves the neural development in cortical organoids. Following organoid grafts transplantation into the injured somatosensory cortices of adult mice, longitudinal electrophysiological recordings and histological assays reveal that ultrasound-treated organoid grafts undergo advanced maturation. They also exhibit enhanced pain-related gamma-band activity and more disseminated projections into the host brain than the untreated groups. Finally, low-intensity ultrasound ameliorates neuropathological deficits in a microcephaly brain organoid model. Hence, low-intensity ultrasound stimulation advances the development and integration of brain organoids, providing a strategy for treating neurodevelopmental disorders and repairing cortical damage.

Nick bostroms simulation argument.

Have you ever paused, looked around, and wondered if everything you see, feel, and experience is real? Or could it be that we’re living in a sophisticated simulation, indistinguishable from reality?

This thought isn’t just a plot from a sci-fi movie; it’s a serious philosophical argument proposed by Nick Bostrom, known as the Simulation Argument. If you’ve ever questioned the nature of reality or pondered over the mysteries of existence, this exploration is for you.

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One of the most debated ethical concerns regarding brain organoids is the possibility that they will become conscious (de Jongh et al. 2022). Currently, many researchers believe that human brain organoids will not become conscious in the near future (International Society for Stem Cell Research 2021). However, several consciousness theories suggest that even existing human brain organoids could be conscious (Niikawa et al. 2022). Further, the feasibility depends on the definition of “consciousness.” For the sake of argument, we assume that human brain organoids can be conscious in principle and examine the legal implications of three types of “consciousness” in the order in which they could be easiest to realize. The first is a non–valenced experience—a mere sensory experience without positive or negative evaluations. The second is a valenced experience or sentience— an experience with evaluations such as pain and pleasure. The third is a more developed cognitive capacity. We assume that if any consciousness makes an entity a subject of (more complex) welfare, it may need to be legally (further) protected.

As a primitive form of consciousness, a non–valenced experience will, if possible, be realized earlier by human brain organoids than other forms of consciousness. However, the legal implications remain unclear. Suppose welfare consists solely of a good or bad experience. In that case, human brain organoids with a non–valenced experience have nothing to protect because they cannot have good or bad experiences. However, some argue that non–valenced experiences hold moral significance even without contributing to welfare. In addition, welfare may not be limited to experience as it has recently been adopted in animal ethics (Beauchamp and DeGrazia 2020). Adopting this perspective, even if human brain organoids possess only non–valenced experiences—or lack consciousness altogether—their basic sensory or motor capacities (Kataoka and Sawai 2023) or the possession of living or non-living bodies to utilize these capacities (Shepherd 2023), may warrant protection.

Hiding or sharing secrets impacts brain function, stress levels, and emotional well-being, and can have a major effect on relationships.

The world’s top neuroscientists are assembling to crack the ultimate code of brain science.

The changes may help explain the link between maternal infection and autism, though more research is needed.

Read the article: https://www.thetransmitter.org/organo…

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What is the nature of quantum physics? Neil deGrasse Tyson and comedian Chuck Nice get quantum, exploring Schrodinger’s Cat, electrons, Hilbert Space, and the biggest ideas in the universe (in the smallest particles) with theoretical physicist Sean Carroll.

When did the idea of fields originate? Are fields even real or are they just mathematically convenient? We explore electrons, whether they are a field, and whether they exist at all. We also discuss the wave function, Hilbert Space, and what quantum mechanics really is. Do superpositions always exist?

Continue reading “Neil deGrasse Tyson and Sean Carroll Discuss Controversies in Quantum Mechanics” »