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New insights into the opposing actions of serotonin-producing nerve fibers in mice could lead to drugs for treating addiction and major depression.

Scientists in Japan have identified a nerve pathway involved in the processing of rewarding and distressing stimuli and situations in mice.

The new pathway, originating in a bundle of brain stem nerve fibers called the median raphe nucleus, acts in opposition to a previously identified reward/aversion pathway that originates in the nearby dorsal raphe nucleus. The findings, published by scientists at Hokkaido University and Kyoto University with their colleagues in the journal Nature Communications, could have implications for developing drug treatments for various mental disorders, including addiction and major depression.

New research in Biological Psychiatry offers the first direct evidence of diminished 5-HT release cements “serotonin hypothesis.”

Researchers have postulated since the 1960s that major depression stems from disruptions in the serotonin neurotransmitter system. However, the evidence for that idea, though plentiful, was indirect. In fact, a recent comprehensive analysis of existing studies concluded that there was not strong evidence to support the “serotonin hypothesis.” In its wake, some in the field have called for a reexamination of the hypothesis. Not so fast, says a new study that provides direct evidence of disrupted serotonin release in the brains of individuals with depression.

The study was published recently in the journal Biological Psychiatry.

As a general rule, if you want sight, you need light. You’re only reading this right now thanks to the light from your screen being beamed onto your retinas, converted into electrical signals, and sent up the optic nerve for your brain to interpret as a bunch of words and images.

But what if you could see things without all that rigamarole? It might sound impossible – perhaps even counter to the very definition of sight – but thanks to the bizarre world of quantum mechanics, it’s actually perfectly possible.

“Since the inception of quantum mechanics, the quest to understand measurements has been a rich source of intellectual fascination,” notes a new paper published this month.

Brain computer interface. People even so called experts are so narrow they have lobotimized their vision.

Share your videos with friends, family, and the world.

A team led by UCL and UCLH researchers have mapped the parts of the brain that support our ability to solve problems without prior experience—otherwise known as fluid intelligence.

Fluid intelligence is arguably the defining feature of human cognition. It predicts educational and professional success, social mobility, health, and longevity. It also correlates with many cognitive abilities such as memory.

Fluid intelligence is thought to be a key feature involved in “active thinking”—a set of complex mental processes such as those involved in abstraction, judgment, attention, strategy generation and inhibition. These skills can all be used in everyday activities—from organizing a dinner party to filling out a tax return.

Although genetically modified foods still get a bit of a bad rap, there are actually many good reasons why modifying an organism’s genetics may be worthwhile. For example, many breeds of genetically modified foods have made them more resistant to disease.

It’s also possible to modify foods to make them more nutritious. Take, for example, golden rice. This grain was engineered to have higher levels of vitamin A in order to tackle deficiencies of this nutrient in impoverished countries.

A purple tomato, created using genetic modification, may be available to buy in the U.S. as soon as 2023.

South Korea has reported its first death due to Naegleria fowleri or ‘Brain-eating amoeba.’ The amoeba enters through the nose and attacks the brain, causing meningitis. Should you be scared?

#SouthKorea #amoeba #WION

Continue reading “Gravitas: South Korea reports first ‘brain-eating amoeba’ death” »

PITTSBURGH — A group of neuroscientists led by a University of Pittsburgh School of Medicine researcher developed a test to detect a novel marker of Alzheimer’s disease neurodegeneration in a blood sample. A study on their results was published today in Brain.

The biomarker, called “brain-derived tau,” or BD-tau, outperforms current blood diagnostic tests used to detect Alzheimer’s-related neurodegeneration clinically. It is specific to Alzheimer’s disease and correlates well with Alzheimer’s neurodegeneration biomarkers in the cerebrospinal fluid (CSF).

A group of neuroscientists led by a Pitt School of Medicine researcher developed a test to detect a novel marker of Alzheimer’s disease neurodegeneration in a blood sample.

EEG hyperscanning during multiuser gaming offers opportunities to study brain characteristics of social interaction under various paradigms. In this study, we aimed to characterize neural signatures and phase-based functional connectivity patterns of gaming strategies during collaborative and competitive alpha neurofeedback games. Twenty pairs of participants with no close relationship took part in three sessions of collaborative or competitive multiuser neurofeedback (NF), with identical graphical user interface, using Relative Alpha (RA) power as a control signal. Collaborating dyads had to keep their RA within 5% of each other for the team to be awarded a point, while members of competitive dyads scored points if their RA was 10% above their opponent’s. Interbrain synchrony existed only during gaming but not during baseline in either collaborative or competitive gaming. Spectral analysis and interbrain connectivity showed that in collaborative gaming, players with higher resting state alpha content were more active in regulating their RA to match those of their partner. Moreover, interconnectivity was the strongest between homologous brain structures of the dyad in theta and alpha bands, indicating a similar degree of planning and social exchange. Competitive gaming emphasized the difference between participants who were able to relax and, in this way, maintain RA, and those who had an unsuccessful approach. Analysis of interbrain connections shows engagement of frontal areas in losers, but not in winners, indicating the formers’ attempt to mentalise and apply strategies that might be suitable for conventional gaming, but inappropriate for the alpha neurofeedback-based game. We show that in gaming based on multiplayer non-verbalized NF, the winning strategy is dependent on the rules of the game and on the behavior of the opponent. Mental strategies that characterize successful gaming in the physical world might not be adequate for NF-based gaming.

Humans are social creatures whose behavior and consciousness are heavily shaped by their environment. Hence, it is natural that hyperscanning, a technique which involves simultaneous recording of physiological activity from more than one subject, is used to deepen our understanding of human interaction. In recent years, hyperscanning has been applied to brain activity to shed light on the neurophysiological representation of various types of interpersonal communication. These range from verbal interaction (Pérez et al., 2017; Ahn et al., 2018), leader-imitator (Dumas et al., 2010; Yun et al., 2012), joint attention and joint decision-making (Toppi et al., 2016; Hu et al., 2018), to teaching or playing music in a duet (Sänger et al., 2012; Müller et al., 2013). Moreover, the neurological coupling of mothers and their infants was investigated for positive and negative emotions and their regulation (Reindl et al., 2018; Santamaria et al., 2020).