Lifeboat Foundation

Technology on the nanometre scale could provide solutions to move on from the solid-state era.

Although chemotherapy can be a lifesaving treatment for patients with cancer, some of these medications can damage the heart. A team led by researchers at Massachusetts General Hospital (MGH) recently developed a nanoparticle probe that can detect an indicator of heart damage from chemotherapy.

Experiments with the probe also revealed that in mice with cancer, intermittent fasting before chemotherapy can prevent this heart damage indicator from arising, leading to preserved cardiac function and prolonged survival.

The study, which is published in Nature Biomedical Engineering, focused on autophagy—a process that cells use to remove unnecessary or dysfunctional components. A delicate balance exists between the protective and deleterious effects of this process: reduced levels of autophagy have been implicated in cardiovascular disease and other conditions; however, autophagy can also be a primary mechanism of cell death.

Circa 2012 o.o!!!

We report on two extensions of the traditional analysis of low-dimensional structures in terms of low-dimensional quantum mechanics. On one hand, we discuss the impact of thermodynamics in one or two dimensions on the behavior of fermions in low-dimensional systems. On the other hand, we use both quantum wells and interfaces with different effective electron or hole mass to study the question when charge carriers in interfaces or layers exhibit two-dimensional or three-dimensional behavior.

Most of us have felt the shock from static electricity by touching a metallic object after putting on a sweater or walking across a carpet. This occurs as a result of charge build-up whenever two dissimilar materials (such as our body and the fabric) come in contact with each other.

In 2012, scientists from the U.S. and China used this phenomenon, known as “triboelectric effect,” to build a triboelectric nanogenerator (TENG) that converts unused mechanical energy into useful electrical energy. Their device consisted of two triboelectric polymer films with metallic electrodes, which, when brought together and separated, resulted in charge separation and the development of an electric voltage sufficient to power small electronic devices.

Viewed as potential sustainable energy harvesters, efforts have been made to enhance the power output of TENGs by injecting charges to the surface of triboelectric films. However, charge recombination in the electrode and charge repulsion on the surface of the material prevents them from achieving high surface charge densities.

In recent years, ribonucleic acid (RNA) has emerged as a powerful tool for the development of novel therapies. RNA is used to copy genetic information contained in our hereditary material, the deoxyribonucleic acid (DNA), and then serves as a template for building proteins, the building blocks of life. Delivery of RNA into cells remains a major challenge for the development of novel therapies across a broad range of diseases. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden together with researchers from the global biopharmaceutical company AstraZeneca have investigated where and how mRNA is delivered inside the cell. They found that mRNA uses an unexpected entry door. Their results provide novel insights into the development of RNA therapeutics towards efficient delivery and lower dosages.

DNA (deoxyribonucleic acid) contains the genetic information required for the development and maintenance of life. This information is communicated by messenger ribonucleic acid (mRNA) to make proteins. mRNA-based therapeutics have the potential to address unmet needs for a wide variety of diseases, including cancer and cardiovascular disease. mRNA can be delivered to cells to trigger the production, degradation or modification of a target protein, something impossible with other approaches. A key challenge with this modality is being able to deliver the mRNA inside the cell so that it can be translated to make a protein. mRNA can be packed into lipid nanoparticles (LNPs)—small bubbles of fat—that protect the mRNA and shuttle it into cells. However, this process is not simple, because the mRNA has to pass the membrane before it can reach its site of action in the cell interior, the cytoplasm.

Researchers in the team of MPI-CBG director Marino Zerial are experts in visualizing the cellular entry routes of molecules in the cell, such as mRNA with high-resolution microscopes. They teamed up with scientists from AstraZeneca who provided the researchers with lipid nanoparticle prototypes that they had developed for therapeutic approaches to follow the mRNA inside the cell. The study is published in the Journal of Cell Biology.

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells. Their approach involves packing mRNA inside nanoparticles that mimic the flu virus—a naturally efficient vehicle for delivering genetic material such as RNA inside cells.

The new mRNA delivery nanoparticles are described in a paper published recently in the journal Angewandte Chemie International Edition.

The work addresses a major challenge in the field of drug delivery: Getting large biological drug molecules safely into cells and protecting them from organelles called endosomes. These tiny acid-filled bubbles inside the cell serve as barriers that trap and digest large molecules that try to enter. In order for biological therapeutics to do their job once they are inside the cell, they need a way to escape the endosomes.

Materials that can carry CRISPR gene-editing into plant cells could be key in the fight against global hunger.

Skyrmions are ultra-stable atomic objects first discovered in real materials in 2009, which have more recently also been found also to exist at room temperatures. These unique objects have a number of desirable properties, including a substantially small threshold voltage, nanoscale sizes and easy electrical manipulation.

While these properties could be advantageous for the creation of a wide range of electronics, developing functional all–electrical devices using skyrmions has so far proved to be very challenging. One possible application for skyrmions is in neuromorphic computing, which entails the creation of artificial structures that resemble those observed in the human brain.

With this in mind, researchers at the Korea Institute of Science and Technology (KIST) have recently investigated the possibility of using skyrmions to replicate mechanisms observed in the human brain. Their paper, published in Nature Electronics, shows that these ultra-stable atomic structures can be used to mimic some behaviors of biological synapses, which are junctions between neurons through which nerve impulses are passed on to different parts of the human brain.

A team of researchers from Nanjing University of Posts and Telecommunications and the Chinese Academy of Sciences in China and Nanyang Technological University and the Agency for Science Technology and Research in Singapore developed an artificial neuron that is able to communicate using the neurotransmitter dopamine. They published their creation and expected uses for it in the journal Nature Electronics.

As the researchers note, most machine-brain interfaces rely on electrical signals as a communications medium, and those signals are generally one-way. Electrical signals generated by the brain are read and interpreted; signals are not sent to the brain. In this new effort, the researchers have taken a step toward making a brain-machine interface that can communicate in both directions, and it is not based on electrical signals. Instead, it is chemically mediated.

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