This creature can regress to the larval stage. Sometimes better start from the beginning đ
Meet the tiny, gelatinous animal that has found a way to live forever.
Not in leading research but interesting.
According to a new study, a polyphenol-rich natural extract positively impacts lifespan, healthspan, and cellular senescence. These results were observed in both cell culture and a mouse model [1].
Traditional and folk medicines offer many botanical extracts that can be tested by modern science for their medicinal properties and influences on aging. One such plant is the Bolivian prawn sage (Salvia haenkei).
Continue reading “A Botanical Extract Extends Lifespan and Healthspan in Mice” »
The Longevity Biotech Fellowship is a non-profit community for people to come together to build, join, or invest in revolutionary longevity biotechnology projects. The Fellowship was founded in 2022 by Nathan Cheng, Mark Hamalainen, and Jun Axup as part of LessDeath Incâ an IRS-approved 501©3 non-profit based in California.
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Personal identity seems so strong. We have the same sense of ourselves throughout our lives, even though everything about our physical bodies and brains is changing constantly. What then causes the continuity of personal identity? Where does transhumanism fit in? Some say personal identity is an illusion, but that seems like cheating. Others credit a nonphysical soul. That seems as though itâs cheating too.
Continue reading “Natasha Vita-More â What Makes Personal Identity Continue?” »
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Itâs no revelation that the human body undergoes natural wear and tear as we age. But you might be surprised to discover that this process isnât as gradual as weâd presumed.
A recent study reveals some remarkable truths about aging, specifically when and how our bodies start to âbreak downâ
The man at the helm of the study is Michael Snyder. Chair of genetics at Stanford School of Medicine and recognized for his exceptional contribution to the field, his teamâs research provides some fascinating insights into the specifics of our biological aging process.
Researchers found that removing certain inflammation-causing cells from mice every month, starting in their middle age, not only extended their lifespans but also improved their heart health and overall physical function throughout their lives. This method shows promise for extending the period of good health as mice age, potentially pointing to new aging treatments for humans.
Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, University of Connecticut researchers have demonstrated a treatment that could lengthen lifeâand vigorâup to the very end.
Even as human lifespans have lengthened over the past century, most people in old age suffer a serious health decline in the last decade of life. Chronic illnesses such as cancer, diabetes, or cardiovascular disease may begin, followed by frailty. Many interventions can prolong life, but not necessarily good health. And nobody wants to spend the last years of an extra-long life in decrepitude.
Significant change can be stressful â divorce, death and moving all make the list â but when it comes to aging, a new paper identifies two flashpoints of enormous biological change. The recent study, by researchers at Stanford Medicine, uncovered evidence that human aging does not occur at a constant, gradual pace â but rather is marked by two significant bursts of molecular change. These bursts, observed in people around the ages of 44 and 60, suggest that aging may be driven by more complex biological processes than previously thought. The findings, published in Nature Aging, are based on comprehensive multi-omics profiling of 108 participants, providing a detailed look at how the human body changes during these key periods of life [1].
Longevity. Technology: The research sheds light on the nonlinear nature of aging, challenging the traditional view that aging is a steady, continuous process. By understanding why and how these bursts of aging occur, scientists may be able to uncover more about the mechanisms of aging and leverage that knowledge to improve both lifespan and healthspan. The findings also highlight the ever-evolving nature of aging research, which continues to refine our understanding of how and why we age.
The Stanford Medicine team, led by Professor Michael Snyder, PhD, analyzed a vast array of molecular data from participants aged between 25 and 75 years. Over a period spanning several years, the researchers collected blood and other biological samples from the participants, tracking more than 135,000 different molecules and microorganisms. The data set included a total of nearly 250 billion distinct data points, making this one of the most comprehensive studies of its kind [1].
First described by Nedergaard and her colleagues in 2012, the glymphatic system is the brainâs unique waste removal process that uses cerebrospinal fluid (CSF) to wash away excess proteins generated by energy hungry neurons and other cells in the brain during normal activity.
A drug used to induce labor in pregnant women has been shown to reactivate tiny waste-clearing pumps in the brains of old mice. The finding could hold promise as a new way to fight Alzheimerâs and Parkinsonâs diseases and overall cognitive decline.
When our brains are working properly, there is an excess of proteins that build up from the energy intensive processes that take place between our neurons. Those proteins need to be removed in order for the brain to continue to operate properly. When they arenât, they can gunk up the works, leading to the beta amyloid and tau protein tangles that are a hallmark of Alzheimerâs disease or the build up of alpha-synuclein that accompanies Parkinsonâs.
Continue reading “Common drug restores youthful function to clean up aging brains” »
