Lifeboat Foundation

An aging/longevity link, (not sure how novel)

As life expectancies around the world increase, so are the number of people who will experience age-related cognitive decline. The amount of oxygen in the blood declines with age. Aging in the brain might be naturally held at bay by adenosine receptor A2B (ADORA2B), a protein on the membrane of red blood cells which is known to help release oxygen from the blood cells so it can be used by the body.

Aging in the brain is naturally reduced by ADORA2B, which helps get oxygen to the brain when needed. Further testing will be needed to determine whether ADORA2B levels naturally decline with age and whether treatment with drugs that activate ADORA2B can reduce cognitive decline in normal mice.

Continue reading “Anti-aging Protein in Blood Cells Helps Slow Cognitive Decline” »

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Cellular senescence, a state of permanent growth arrest, has emerged as a hallmark and fundamental driver of organismal aging. It is regulated by both genetic and epigenetic factors. Despite a few previously reported aging-associated genes, the identity and roles of additional genes involved in the regulation of human cellular aging remain to be elucidated. Yet, there is a lack of systematic investigation on the intervention of these genes to treat aging and aging-related diseases.

How many aging-promoting genes are there in the human genome? What are the molecular mechanisms by which these genes regulate aging? Can gene therapy alleviate individual aging? Recently, researchers from the Chinese Academy of Sciences have shed new light on the regulation of aging.

Continue reading “Scientists Develop New Gene Therapy Strategy to Delay Aging and Extend Lifespan” »

BOSTON (PRWEB) November 18, 2020

What does it mean for multiplying cells in the body to be immortal? The cell DNA is being replicated over and over again while being divided equally between new cells produced by cell divisions. All the new cell components produced by the DNA code are mixing with the old cell components and being divided between the new cells. So, every cell is a new cell. There is nothing really immortal about any of them. Right?

Not quite. Stem cells responsible for renewing other mature body cells are different. For a long time, tissue cell scientists had a somewhat nebulous idea that stem cells had a special longevity in organs and tissues – that they were immortal cells, lasting for as long as the human lifespan. However, no one had a molecular concept for this idea of stem cell immortality until John Cairns, a pioneer of DNA replication, started thinking about DNA mutations and cancer in the 1970’s.

Circa 2013 henrietta lacks unlimited cell division sequenced allowing for immortality.

The HeLa cell genome is riddled with errors, raising questions about its continued use.

In America, at least 17 people a day die waiting for an organ transplant. But instead of waiting for a donor to die, what if we could someday grow our own organs?

Last week, six years after NASA announced its Vascular Tissue Challenge, a competition designed to accelerate research that could someday lead to artificial organs, the agency named two winning teams. The challenge required teams to create thick, vascularized human organ tissue that could survive for 30 days.

The two teams, named Winston and WFIRM, both from the Wake Forest Institute for Regenerative Medicine, used different 3D-printing techniques to create lab-grown liver tissue that would satisfy all of NASA’s requirements and maintain their function.

Continue reading “NASA inches closer to printing artificial organs in space” »

HOMA calculator: https://www.omnicalculator.com/health/homa-ir.

Papers referenced in the video:
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.
https://pubmed.ncbi.nlm.nih.gov/24175087/

Continue reading “Insulin Sensitivity Is A Hallmark Of Longevity” »

Experts predict that we’ll be able to live up to 20% longer over the next 100 years. Here’s how humans are trying to live forever. Andrea Schmitz and Benji Jones Apr 3, 2019, 12:00 PM @ These potential treatments for aging could unlock cures to a range of age-related illnesses, from cancer to heart disease – Charlotte Hu Aug 20, 2018, 1:21 PM @ Animals that defy the rules of aging — like naked mole rats — could help scientists unravel the secrets to longevity – Charlotte Hu Aug 15, 2018, 2:54 PM @ Everything you thought you knew about aging is wrong – Erin Brodwin Apr 27, 2016, 12:13 PM *© 2021 Insider Inc. @ Other very important information, images, YouTube Videos (Ray Kurzweil – Physical Immortality – 3 de jan. de 2017 & Ray Kurzweil + Disruptive Technologies and Dangerous Ideas – 5 de dez. de 2017), websites, social networks and links.

Hello everybody! In this episode, we interview Felix Werth, a trully hero of the rejuvenation field: in 2015 he created a party in Germany to defend more investments in our field, and his party is contesting the general elections in the country on September 26th 2021! However, he needs our help right now, since his party has until July 19th to collect enough signatures to participate in 14 German states covering 98% of the country’s population. So be sure to check the interview and the party’s website (https://parteifuergesundheitsforschung.de) to see how you can help.

In this episode of ImmortaliCast, Nicolas and Nina talk to Felix Werth, the founder and leader of the German Party for Health Research, a party with a single issue: 10% of the government budget should be spent on research for the development of treatments of age-related diseases. The party will contest the German general elections of September 26th 2021.

Continue reading “Felix Werth: The rejuvenation field in the ballot in Germany” »

We may have progressed beyond drinking mercury to try to prolong life. Instead, by a British government estimate, we have what may be called the ‘immortality industrial research complex’ – using genomics, artificial intelligence and other advanced sciences, and supported worldwide by governments, big business, academics and billionaires – that’s worth US$110 billion today and US$610 billion by 2025.

We are living longer than at any time in human history. And while the search is on for increased longevity if not immortality, new research suggests biological constraints will ultimately determine when you die.