Lifeboat Foundation

Summary: A new study reveals that the absence of the TRMT10A enzyme disrupts tRNA levels, leading to impaired protein synthesis and brain function. Researchers found that mice lacking the Trmt10a gene had decreased levels of key tRNAs, which affected neuronal synapses and cognitive abilities.

The findings suggest that while tRNA reduction occurs in multiple tissues, the brain is particularly vulnerable to its effects. This research could pave the way for new therapies targeting tRNA modification to treat intellectual disabilities.

Researchers at the University of Hawaiʻi at Mānoa have unveiled a new technique that could make the manufacture of wearable health sensors more accessible and affordable.

Deep-learning models are being used in many fields, from health care diagnostics to financial forecasting. However, these models are so computationally intensive that they require the use of powerful cloud-based servers.

This is actually an addition to Genevieve’s post on CubeSat.

Humans are returning to the Moon for the first time in decades, and we intend to stay. NASA’s Artemis missions are preparing for a sustained human presence on and around the Moon, with the ultimate goal of sending humans to Mars. These deep-space destinations present health risks to astronauts that are qualitatively and quantitatively different from those associated with stays on the International Space Station (ISS). One of the most significant risks for astronauts venturing outside the protection of Earth’s magnetic field is ionizing radiation: Galactic Cosmic Rays (GCR), Solar Particle Events (SPE), and the “albedo” radiation produced by the interaction of space radiation with the lunar surface. Exposure to ionizing radiation can result in an increased risk of cancer, cardiovascular disease, and neurological impairment.

Hi folks, I’d like to invite you to a webinar I will be giving on my research, hosted by the Foresight Institute! It takes place this Friday at 12:00pm CST. You can sign up on the linked page. The donation is optional, so if you don’t want to donate, you can just put $0.00. I hope to see you there!

Biotech and Health Extension sponsored by 100 Plus Capital

Viruses inside vaults: a powerful new gene therapy delivery system

Continue reading “Logan Collins” »

Scientists have developed microscopic robots capable of treating brain aneurysms with unprecedented precision, offering a potential alternative to invasive brain surgeries. An international team, including researchers from the University of Edinburgh, engineered these nanorobots to safely and accurately deliver life-saving medications to the brain. This advancement comes in the context of a global health challenge, […].

This was created by a company called Xenex a decade ago In San Antonio Texas, where I used to live.

JOINT BASE LANGLEY-EUSTIS, Va. (AFNS) — Standing at 5 feet 2 inches tall, U.S. Air Force Hospital Langley’s newest staff member doesn’t initially have a commanding presence; however, after five minutes, its impact has the potential to save countless lives around the world.

The 633rd Medical Group received a germ-zapping robot, nicknamed “Saul,” which harnesses the power of technology to kill off viruses — including the Ebola virus. Airmen were given a demonstration of the robots functions and capabilities from Geri Genant, the Xenex Healthcare Services implementation manager.

Continue reading “AF hospital adds ‘virus-zapping’ robot to inventory” »

The SARS-CoV-2 pandemic has had an unprecedented impact on global public health and the economy. Although vaccines and antivirals have provided effective protection and treatment, the development of new small molecule-based antiviral candidates is imperative to improve clinical outcomes against SARS-CoV-2. In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells. UNI418 inhibited the proteolytic activation of cathepsins, which is regulated by PIKfyve, resulting in the inhibition of cathepsin L-dependent proteolytic cleavage of the SARS-CoV-2 spike protein into its mature form, a critical step for viral endosomal escape. We also demonstrated that UNI418 prevented ACE2-mediated endocytosis of the virus via PIP5K1C inhibition. Our results identified PIKfyve and PIP5K1C as potential antiviral targets and UNI418 as a putative therapeutic compound against SARS-CoV-2.

Despite the ongoing threat posed by new viruses following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the coronavirus disease 2019 (COVID-19) pandemic, new antiviral drugs continue to be developed to effectively block viral entry into the human body.

Professor Kyungjae Myung and his research team in the Department of Biomedical Engineering, affiliated with the IBS Center for Genomic Integrity, has discovered UNI418, a compound that effectively prevents the penetration of the coronavirus. This compound works by regulating dielectric homeostasis, thereby inhibiting the virus’s entry into human cells.

The Allen Institute for Immunology has released its first Human Immune Health Atlas, a comprehensive single-cell reference dataset that offers unprecedented insight into the landscape of healthy human immune cells from childhood through adulthood.

Comprehensive dataset maps the landscape of healthy immune cells across the human lifespan.