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Category: genetics – Page 430

Life extension genetics.

Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses.

Meta-analyses of genetic polymorphisms previously associated with exceptional longevity (85+) were undertaken. For each variant, meta-analyses were performed if there were data from at least three independent studies available, including two unpublished additional cohorts.

Five polymorphisms, ACE rs4340, APOE ε2/3/4, FOXO3A rs2802292, KLOTHO KL-VS and IL6 rs1800795 were significantly associated with exceptional longevity, with the pooled effect sizes (odds ratios) ranging from 0.42 (APOE ε4) to 1.45 (FOXO3A males).

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“I believe gene therapy will become a mainstay in treating, and maybe curing, many of our most devastating and intractable illnesses,” said FDA commissioner Dr Scott Gottlieb after Luxturna’s approval.

As innovative gene and cell therapies continue to make the transition from the laboratory to the clinic, they are bringing with them the promise of truly personalised medicine. The last few years have seen the regulatory approval of the first gene therapies that take a patient’s own immune cells and genetically engineer them to target cancer cells more effectively.

These chimeric antigen receptor T-cell (CAR-T) therapies now represent a rapidly growing field, with Novartis’s Kymriah, the first CAR-T therapy approved by the US Food and Drug Administration (FDA) in August 2017 for the treatment of a rare blood cancer, seen as the tip of the iceberg for this treatment class’ potential. Approval of Kite Pharma’s Yescarta, a CAR-T treatment for certain forms of non-Hodgkin lymphoma, followed just a few months later.

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Monsanto’s agricultural biotechnology research and development operations that are going to Bayer are the largest in the world and include making genetically modified seeds for such crops as corn, soybeans and cotton. Corn represented almost 60 percent of Monsanto’s total seed and genomics business last year.

German conglomerate Bayer on Thursday closed its $63 billion merger with St. Louis-based agribusiness giant Monsanto and plans to drop the U.S. company’s name.

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A being that can consciously alter its own DNA via technological intervention (i.e. cybernetic means) is what our Second Womb has been nurturing. We have used civilization to protect ourselves while we crack the code of our biological being. We started in the womb of the cave. Then moved on to the womb of the hut. Then the village, the city, and the state. All thew hile, we have been tinkering with our own DNA and the DNA of other species. To me, this is the real posthuman or transhuman — it is the creature that is actively editing its own biological blueprint through tech. This is what we’ve been doing since we started augmenting our bodies with clothing and animal skins. We’ve been modifying our ability to endure the slings and arrows of the cosmos.

What is human civilization? It is difficult to assert that other animals do not create their own civilizations — termites for instance meet some criteria for being categorized as cyborgs (building temperature-controlled mega structures). Animals communicate, express feelings, and have personalities. Octopi arrange furniture for would-be mates. Others engage in mating rituals. Some mourn the dead. Birds can solve simple math. Critters scheme, enterprise, forge bonds, and even produce art. What do we do that animals do not?

To our credit, we are the only animals that record, share, and develop history upon structures and materials outside of our bodies. We harness energy for massive projects. We farm, but again, so do leaf-cutter ants. But we create genetically novel vegetables and animals. We alter the global climate. Our enterprises are global, and given time and opportunity, our projects will eventually become exostellar. We do all this rather ferociously. Human history is a rather short explosion of civilization-building activities, and yet it might already have irrevocably altered the future of all life on this planet. No other creature has created a circumstance quite like that of human beings and our anthropocene project. For instance, unless we clean up the environment, the next few generations of plant and animal life are going to have be extremely resilient to radiation, Styrofoam, plastics, and other run-offs squeezed out from the human project. That is just a fact of life now on earth.

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Maryam shanechi, university of southern california.

With recent technological advances, we can now record neural activity from the brain, and manipulate this activity with electrical or optogenetic stimulation in real time. These capabilities have brought the concept of brain-machine interfaces (BMI) closer to clinical viability than ever before. BMIs are systems that monitor and interact with the brain to restore lost function, treat neurological disorders, or enhance human performance.

February 2018

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Polio was a devastating disease before the development of the polio vaccine. But now, this once-feared virus might help treat another deadly illness — brain cancer.

In a new study, some patients who had an aggressive type of brain cancer called glioblastoma and who received a genetically modified poliovirus lived much longer than typical for these patients.

The study found that about 21 percent of the brain cancer patients who received the poliovirus therapy were alive three years later. In contrast, among a group of previously treated patients who had the same cancer but received standard therapies (such as chemotherapy), just 4 percent were alive after three years.

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A remarkable new study has successfully used the CRISPR-Cas9 gene editing technique to edit a specific gene in mice engineered to have fragile X syndrome (FXS), a single-gene disorder often related to autism. The single gene edit in the live mice resulted in significant improvements in repetitive and obsessive behaviors, making this the first time gene editing has been used to effectively target behavioral symptoms related to autism spectrum disorder (ASD).

FXS is a genetic disorder associated with intellectual disability, seizures and exaggerated repetitive behavior. Previous studies have shown that the repetitive behaviors associated with FXS are related to a specific excitatory receptor in the brain that, when dysregulated, causes exaggerated signaling between cells.

The CRISPR technique homes in on the gene that controls that excitatory receptor, the metabotropic glutamate receptor 5 (mGluR5), and essentially disables it, dampening the excessive signaling the corresponds with repetitive behaviors. In mice treated with the new system, obsessive digging behavior was reduced by 30 percent and repetitive leaping actions dropped by 70 percent.

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While cholera rages across many regions of the world, a team of microbiologists and plant scientists has pinpointed a genetic weakness in the pandemic’s armor, which could lead to future treatments.

The current cholera began in Indonesia in 1961. Rather than fade away like its six previous worldwide outbreak predecessors, the responsible strain is thriving and actually picking up steam. A discovery, led by scientists from Michigan State University and Tufts University and featured in the current issue of PNAS, shows the key genetic change the seventh pandemic acquired to thrive for more than 50 years.

The interdisciplinary team of scientists reveal the first ever signaling network for a new bacterial signal, cyclic GMP-AMP (cGAMP), in the human cholera pathogen. The team also identified the first protein receptor of cGAMP as a phospholipase enzyme that remodels the V. cholerae membrane when cGAMP is produced.

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Deep in the rocky earth, in the liquid-filled cracks created by fracking, lives a community of highly interactive microbes—one that could at once have serious implications for energy companies, human health and scientists investigating the potential for life on Mars.

New research has uncovered the genetic details of microbes found in fracking wells. Not only do a wide array of bacteria and viruses thrive in these crevices created by hydraulic fracturing—they also have the power to produce methane, according to a study led by scientists at The Ohio State University and published in the journal Proceedings of the National Academy of Sciences.

That means it’s possible that the tiny life forms could create more energy—and from a different source—than the fracking companies are going after in the first place.

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