Lifeboat Foundation

The question of how the chemical composition of a protein—the amino acid sequence—determines its 3D structure has been one of the biggest challenges in biophysics for more than half a century. This knowledge about the so-called “folding” of proteins is in great demand, as it contributes significantly to the understanding of various diseases and their treatment, among other things. For these reasons, Google’s DeepMind research team has developed AlphaFold, an artificial intelligence that predicts 3D structures.

A team consisting of researchers from Johannes Gutenberg University Mainz (JGU) and the University of California, Los Angeles, has now taken a closer look at these structures and examined them with respect to knots. We know knots primarily from shoelaces and cables, but they also occur on the nanoscale in our cells. Knotted proteins can not only be used to assess the quality of structure predictions but also raise important questions about folding mechanisms and the evolution of proteins.

A team of researchers from IBM Research Europe, Universidade de Santiago de Compostela and the University of Regensburg has changed the bonds between the atoms in a single molecule for the first time. In their paper published in the journal Science, the group describes their method and possible uses for it. Igor Alabugin and Chaowei Hu, have published a Perspective piece in the same journal issue outlining the work done by the team.

The current method for creating complex molecules or molecular devices, as Alagugin and Chaowei note, is generally quite challenging—they liken it to dumping a box of Legos in a washing machine and hoping that some useful connections are made. In this new effort, the research team has made such work considerably easier by using a scanning tunneling microscope (STM) to break the bonds in a molecule and then to customize the molecule by creating new bonds—a chemistry first.

Continue reading “Chemists change the bonds between atoms in a single molecule for the first time” »

High-performance, micro-sized electrochemical energy storage devices are essential for future miniaturized electronic devices, such as smart medical implants, wireless sensors, and the Internet of Things. Microbatteries (MBs) typically show higher energy density and more stable voltage output than micro-supercapacitors.

However, current MBs involve tedious construction procedures and unsatisfactory electrochemical performance. In addition, no methods exist to construct or manipulate a liquid microelectrode.

A joint research team led by Prof. Qu Liangti from Tsinghua University, Prof. Zhang Zhipan from the Beijing Institute of Technology, and Prof. Liu Feng from the Institute of Mechanics of the Chinese Academy of Sciences (IMCAS) recently proposed a dual-plating strategy to rapidly construct new zinc–bromine microbatteries (Zn–Br₂ MBs) with ultrahigh areal energy density and polarity-switchable functionality.

For his work on liquid metal batteries that could enable the long-term storage of renewable energy, MIT Professor Donald Sadoway has won the 2022 European Inventor Award, in the category for Non-European Patent Office Countries.

Sadoway is a longtime supporter and friend of MIT’s Materials Research Laboratory and is the John F. Elliott Professor of Materials Chemistry in MIT’s Department of Materials Science and Engineering.

“By enabling the large-scale storage of renewable energy, Donald Sadoway’s invention is a huge step towards the deployment of carbon-free electricity generation,” says António Campinos, President of the European Patent Office. “He has spent his career studying electrochemistry and has transformed this expertise into an invention that represents a huge step forward in the transition to green energy.”

Ritu Raman leads the Raman Lab, where she creates adaptive biological materials for applications in medicine and machines.

It seems that Ritu Raman was born with an aptitude for engineering. You may say it is in her blood since her mother is a chemical engineer, her father is a mechanical engineer, and her grandfather is a civil engineer. Throughout her childhood, she repeatedly witnessed firsthand the beneficial impact that engineering careers could have on communities. In fact, watching her parents build communication towers to connect the rural villages of Kenya to the global infrastructure is one of her earliest memories. She still vividly remembers the excitement she felt watching the emergence of a physical manifestation of innovation that would have a long-lasting positive impact on the community.

Continue reading “MIT’s Raman Lab: At the Forefront of Building With Biology” »

Join the audience for a live webinar on 20 July 2022 sponsored by TA Instruments – Waters, Hiden Analytical and Royal Society of Chemistry, in partnership with The Electrochemical Society.

A team of scientists in the Physical Intelligence Department at the Max Planck Institute for Intelligent Systems have combined robotics with biology by equipping E. coli bacteria with artificial components to construct biohybrid microrobots. First, as can be seen in Figure 1, the team attached several nanoliposomes to each bacterium. On their outer circle, these spherical-shaped carriers enclose a material (ICG, green particles) that melts when illuminated by near infrared light. Further towards the middle, inside the aqueous core, the liposomes encapsulate water soluble chemotherapeutic drug molecules (DOX).

The second component the researchers attached to the bacterium is magnetic nanoparticles. When exposed to a magnetic field, the iron oxide particles serve as an on-top booster to this already highly motile microorganism. In this way, it is easier to control the swimming of bacteria —an improved design toward an in vivo application. Meanwhile, the rope binding the liposomes and magnetic particles to the bacterium is a very stable and hard to break streptavidin and biotin complex, which was developed a few years prior and reported in a Nature article, and comes in useful when constructing biohybrid microrobots.

E. coli bacteria are fast and versatile swimmers that can navigate through material ranging from liquids to highly viscous tissues. But that is not all, they also have highly advanced sensing capabilities. Bacteria are drawn to chemical gradients such as low oxygen levels or high acidity—both prevalent near tumor tissue. Treating cancer by injecting bacteria in proximity is known as bacteria mediated tumor therapy. The microorganisms flow to where the tumor is located, grow there and in this way activate the immune system of patients. Bacteria mediated tumor therapy has been a therapeutic approach for more than a century.

Biological synapses are known to store multiple memories on top of each other at different time scales, much like representations of the early techniques of manuscript writing known as “palimpsest,” where annotations can be superimposed alongside traces of earlier writing.

Biological palimpsest consolidation occurs via hidden biochemical processes that govern synaptic efficacy at varying lifetimes. The arrangement can facilitate idle memories to be overwritten without forgetting them, while using previously unseen memories short-term. Embedded artificial intelligence can significantly benefit from such functionality; however, the hardware has yet to be demonstrated in practice.

In a new report, now published in Science Advances, Christos Giotis and a team of scientists in Electronics and Computer Science at the University of Southampton and the University of Edinburgh, U.K., showed how the intrinsic properties of metal-oxide volatile memristors mimicked the process of biological palimpsest consolidation.

In the deep subsurface that plunges into the Earth for miles, microscopic organisms inhabit vast bedrock pores and veins. Belowground microorganisms, or microbes, comprise up to half of all living material on the planet and support the existence of all life forms up the food chain. They are essential for realizing an environmentally sustainable future and can change the chemical makeup of minerals, break down pollutants, and alter the composition of groundwater.

While the significance of bacteria and archaea is undeniable, the only evidence of their existence in the deep subsurface comes from traces of biological material that seep through mine walls, cave streams, and drill holes that tap into aquifers.

Many scientists have assumed that the composition of microbial communities in the deep subsurface is primarily shaped by local environmental pressures on microbial survival such as temperature, acidity, and oxygen concentration. This process, environmental selection, can take years to millennia to cause significant community-level changes in slow-growing communities like the subsurface.