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Their research, recently published in the journal Nature, introduces a photocatalytic method that leverages light energy to activate water, potentially opening up new avenues in chemistry, particularly in the synthesis of compounds from simpler materials.
Osteoarthritis (OA) is a prevalent global health concern, posing a significant and increasing public health challenge worldwide. Recently, biomaterials have emerged as a highly promising strategy for OA therapy due to their exceptional physicochemical properties and capacity to regulate pathological processes. However, there is an urgent need for a deeper understanding of the potential therapeutic applications of these biomaterials in the clinical management of diseases, particularly in the treatment of OA. In this comprehensive review, we present an extensive discussion of the current status and future prospects concerning biomaterials for OA… More.
Herein, in this review, we summarize the advanced strategies developed for enhancing OA therapy based on the biomaterials. We conducted a comprehensive literature search using relevant databases such as PubMed, Scopus, and Web of Science. The search was focused on peer-reviewed articles and research papers published within the last ten years (from 2013 to 2023). We utilized specific keywords related to biomaterials”, biomaterials” and “osteoarthritis therapy” to retrieve relevant studies. First, we provide an overview of the pathophysiology of OA and the limitations of current treatment options. Second, we explore the various types of biomaterials which have been used for OA therapy, including nanoparticles, nanofibers, and nanocomposites. Third, we highlight the advantages and challenges associated with the use of biomaterials in OA therapy, such as toxicity, biodegradation, and regulatory issues. Finally, advanced biomaterials-based OA therapies with their potential for clinical translation and emerging biomaterials directions for OA therapy are discussed.
Characteristics of Biomaterials
Nanotechnology-boosted biomaterials have attracted considerable attention in recent years as promising candidates for revolutionizing the field of therapeutics.12,13 These materials combine the unique properties of nanotechnology with the versatility and biocompatibility of biomaterials, offering numerous advantages over existing therapeutic approaches. Nanotechnology enables the precise engineering of biomaterials at the nanoscale, allowing for the encapsulation and controlled release of therapeutic agents, such as drugs and growth factors.14–17 This feature facilitates targeted and sustained drug delivery to specific sites within the body, reducing systemic side effects and enhancing treatment efficacy. In the context of OA, this targeted drug delivery can be utilized to deliver anti-inflammatory agents or disease-modifying drugs directly to affected joint tissues, promoting tissue repair and alleviating symptoms. Furthermore, biomaterials can be designed to mimic the native tissue environment, thereby enhancing their biocompatibility and reducing the risk of adverse reactions or immune responses.18 This characteristic is crucial for successful integration and long-term functionality of biomaterials in biomedical applications. Moreover, nanomaterials can facilitate tissue regeneration by stimulating cellular responses and promoting tissue growth.19 In the context of OA, biomaterials can assist in cartilage repair and regeneration, potentially slowing down disease progression and improving joint function.3 In addition, nanotechnology allows for the customization of biomaterials with a wide range of physical, chemical, and biological properties.13 This flexibility enables the development of multifunctional biomaterials that can simultaneously perform multiple tasks, such as drug delivery, imaging, and tissue regeneration. These advantages collectively contribute to their potential as innovative solutions in addressing various biomedical challenges and improving patient outcomes. In this section, we will discuss some of the key properties of biomaterials and their impact on OA treatment.
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Hydrogen is often touted as a future energy solution, especially when generated through environmentally friendly methods. Beyond its energy potential, hydrogen plays a crucial role in producing active ingredients and various essential compounds. To generate hydrogen, water (H2O) can be transformed into hydrogen gas (H2) through a sequence of chemical reactions.
However, as water molecules are very stable, splitting them into hydrogen and oxygen presents a big challenge to chemists. For it to succeed at all, the water first has to be activated using a catalyst – then it reacts more easily.
A team of researchers led by Prof. Armido Studer at the Institute of Organic Chemistry at Münster University (Germany) has developed a photocatalytic process in which water, under mild reaction conditions, is activated through triaryl phosphines and not, as in most other processes, through transition metal complexes.
To understand why this is a big deal, for a long time its been understood that (to vastly oversimplify things) the brain is primarily composed to two kinds of cells: glial cells, which are basically the brain’s infrastructure; and neurons, which communicate with each other with chemicals called neurotransmitters at special sites called synapses.
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Add another layer of complexity to our understanding of the brain. Researchers at University of Lausanne have discovered that a heretofore unknown class of cell is also involved in the complicated internal communications of the brain. The research was published Wednesday in Nature.
Continue reading “InnovationRx: New Insight Into How The Brain Works” »
For now, cyborgs exist only in fiction, but the concept is becoming more plausible as science progresses. And now, researchers are reporting in ACS’ Nano Letters that they have developed a proof-of-concept technique to “tattoo” living cells and tissues with flexible arrays of gold nanodots and nanowires. With further refinement, this method could eventually be used to integrate smart devices with living tissue for biomedical applications, such as bionics and biosensing.
Advances in electronics have enabled manufacturers to make integrated circuits and sensors with nanoscale resolution. More recently, laser printing and other techniques have made it possible to assemble flexible devices that can mold to curved surfaces. But these processes often use harsh chemicals, high temperatures or pressure extremes that are incompatible with living cells. Other methods are too slow or have poor spatial resolution. To avoid these drawbacks, David Gracias, Luo Gu and colleagues wanted to develop a nontoxic, high-resolution, lithographic method to attach nanomaterials to living tissue and cells.
The team used nanoimprint lithography to print a pattern of nanoscale gold lines or dots on a polymer-coated silicon wafer. The polymer was then dissolved to free the gold nanoarray so it could be transferred to a thin piece of glass. Next, the gold was functionalized with cysteamine and covered with a hydrogel layer, which, when peeled away, removed the array from the glass. The patterned side of this flexible array/hydrogel layer was coated with gelatin and attached to individual live fibroblast cells. In the final step, the hydrogel was degraded to expose the gold pattern on the surface of the cells. The researchers used similar techniques to apply gold nanoarrays to sheets of fibroblasts or to rat brains. Experiments showed that the arrays were biocompatible and could guide cell orientation and migration.
Using a quantum device, researchers have observed, for the first time, a molecular process called conical intersection that is important in reactions such as photosynthesis.
Researchers have created a new 3D-printed substance dubbed “engineered living material.”
Removing pollutants from water is a crucial and arduous process to ensure that it is free from harmful contaminants. In recent years, several approaches and technologies for water pollution remediation have been developed and employed, including filtration, nano-materials, and chemical treatment, to mention a few.
Continue reading “New 3D-printed ‘living material’ could purify water” »
A team of scientists from Ames National Laboratory has developed a new machine learning model for discovering critical-element-free permanent magnet materials. The model predicts the Curie temperature of new material combinations. It is an important first step in using artificial intelligence to predict new permanent magnet materials. This model adds to the team’s recently developed capability for discovering thermodynamically stable rare earth materials. The work is published in Chemistry of Materials.
High performance magnets are essential for technologies such as wind energy, data storage, electric vehicles, and magnetic refrigeration. These magnets contain critical materials such as cobalt and rare earth elements like neodymium and dysprosium. These materials are in high demand but have limited availability. This situation is motivating researchers to find ways to design new magnetic materials with reduced critical materials.
Machine learning (ML) is a form of artificial intelligence. It is driven by computer algorithms that use data and trial-and-error algorithms to continually improve its predictions. The team used experimental data on Curie temperatures and theoretical modeling to train the ML algorithm. Curie temperature is the maximum temperature at which a material maintains its magnetism.
Summary: New findings challenge our understanding of fruit fly social behaviors. While traditionally thought to rely primarily on chemical receptors for social interactions, the fruit fly’s visual system plays a pivotal role too.
By manipulating the visual feedback neurons in male fruit flies, researchers discovered that their social inhibitions were altered, leading males to court other males. This novel insight can potentially enlighten our comprehension of social behaviors in humans, including those with bipolar disorder and autism.
Male fruit flies don’t usually like each other. Socially, they reject their fellow males and zero in on the females they discern via chemical receptors—or so scientists thought.
New research from Cornell University biologists suggests the fruit fly’s visual system, not just chemical receptors, are deeply involved with their social behaviors. The work sheds light on the possible origin of differences in human social behaviors, such as those seen in people with bipolar disorder and autism.
The paper is published in Current Biology.
Osteoarthritis (OA) is a prevalent global health concern, posing a significant and increasing public health challenge worldwide. Recently, biomaterials have emerged as a highly promising strategy for OA therapy due to their exceptional physicochemical properties and capacity to regulate pathological processes. However, there is an urgent need for a deeper understanding of the potential therapeutic applications of these biomaterials in the clinical management of diseases, particularly in the treatment of OA. In this comprehensive review, we present an extensive discussion of the current status and future prospects concerning biomaterials for OA… More.
