Lifeboat Foundation

A new study has uncovered significant differences in how male and female mice process threats, even as they exhibit similar behavioural responses. The discovery suggests that including both male and female subjects in neuroscience research will lead to more accurate conclusions and ultimately better health outcomes. Understanding the influence of sex on brain function can help explain why males and females develop certain psychiatric disorders at different rates or with different symptoms, the researchers said. ‘Unless we thoughtfully and rigorously integrate sex into biomedical research, a huge amount of the population may be underserved by scientific knowledge,’ said McGill University Associate Professor and Canada Research Chair in Behavioural Neurogenomics Rosemary Bagot, who led the study. ‘Our work shows that sex is an important variable to consider, even if initial observations don’t necessarily show clear sex differences,” said Bagot. “If males and females are using different brain circuits to solve similar problems, they may be differently vulnerable to stress and respond differently to treatments.’ How brain circuits process threats and cues The study focused on two related brain circuits and their roles in processing information about threats and the cues that predict them. The researchers trained mice to recognize a sound that signalled a threat and another sound that meant safety. By observing brain activity, the team saw how communication between different brain areas processed these signals. Then, they temporarily turned off each brain connection to see how it affected the mice’s reactions, helping them understand how the brain handles threats. ‘We found that even though male and female mice respond similarly to threats, the brain circuits underlying these responses are not the same,’ Bagot said. For female mice, a connection between two specific brain areas (the medial prefrontal cortex and the nucleus accumbens) played a key role. The study found that in male mice, a different connection (between the ventral hippocampus and the nucleus accumbens) was more important for handling the same situation. It was previously assumed that similar behavior meant similar brain function. Now, the researchers are exploring how sex impacts brain circuits in processing threats, focusing on the role of sex hormones and different learning strategies. This research is supported by funding from CIHR. About the study Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior by Jessie Muir, Eshaan Iyer et al., was published in Nature Neuroscience.

“As complex living systems, we likely have trillions upon trillions of tiny nanoscopic holes in our cells that facilitate and regulate the crucial processes that keep us alive and make up who are,” says Marija Drndić, a physicist at the University of Pennsylvania who develops synthetic versions of the biological pores that “guide the exchange of ions and molecules throughout the body.”

The ability to control and monitor the flow of molecules through these pores has opened new avenues for research in the last two decades, according to Drndić, and the field of synthetic nanopores, where materials like graphene and silicon are drilled with tiny holes, has already led to significant advances in DNA sequencing.

In a paper published in Nature Nanotechnology (“Coupled nanopores for single-molecule detection”), Drndić and Dimitri Monos, her longtime collaborator at the Perelman School of Medicine and Children’s Hospital of Philadelphia (CHOP), presented a new kind of nanopore technology with the development of a dual-layer nanopore system: a design that consists of two or more nanopores, stacked just nanometers apart, which allows for more precise detection and control of molecules like DNA as they pass through.

Noncanonical amino acids are efficiently incorporated into proteins by optimizing mRNA codon usage.

Given the right conditions, certain types of cells are able to self-assemble into new lifeforms after the organism they were once part of has died.

Google researchers have created an innovative AI model called Health Acoustic Representations (HeAR), designed to identify acoustic biomarkers for diseases like tuberculosis.

It can listen to human sounds and flag early signs of disease.

Continue reading “New AI model helps researchers detect disease based on coughs” »

Dr. Sam Parnia talks about reviving people adter they died. Very informative. Fast forward a little to listen to it.

Photonic applications harness the power of light-matter interactions to generate various intriguing phenomena. This has enabled major advances in communications, medicine, and spectroscopy, among others, and is also used in laser and quantum technologies.

In this sense, the cemi theory incorporates Chalmers’ (Chalmers 1995) ‘double-aspect’ principle that information has both a physical, and a phenomenal or experiential aspect. At the particulate level, a molecule of the neurotransmitter glutamate encodes bond energies, angles, etc. but nothing extrinsic to itself. Awareness makes no sense for this kind matter-encoded information: what can glutamate be aware of except itself? Conversely, at the wave level, information encoded in physical fields is physically unified and can encode extrinsic information, as utilized in TV and radio signals. This EM field-based information will, according to the double-aspect principle, be a suitable substrate for experience. As proposed in my earlier paper (McFadden 2002a) ‘awareness will be a property of any system in which information is integrated into an information field that is complex enough to encode representations of real objects in the outside world (such as a face)’. Nevertheless, awareness is meaningless unless it can communicate so only fields that have access to a motor system, such as the cemi field, are candidates for any scientific notion of consciousness.

I previously proposed (McFadden 2013b), that complex information acquires its meaning, in the sense of binding of all of the varied aspects of a mental object, in the brain’s EM field. Here, I extend this idea to propose that meaning is an algorithm experienced, in its entirety from problem to its solution, as a single percept in the global workspace of brain’s EM field. This is where distributed information encoded in millions of physically separated neurons comes together. It is where Shakespeare’s words are turned into his poetry. It is also, where problems and solutions, such as how to untangle a rope from the wheels of a bicycle, are grasped in their entirety.

There are of course many unanswered questions, such as degree and extent of synchrony required to encode conscious thoughts, the influence of drugs or anaesthetics on the cemi field or whether cemi fields are causally active in animal brains. Yet the cemi theory provides a new paradigm in which consciousness is rooted in an entirely physical, measurable and artificially malleable physical structure and is amenable to experimental testing. The cemi field theory thereby delivers a kind of dualism, but it is a scientific dualism built on the distinction between matter and energy, rather than matter and spirit. Consciousness is what algorithms that exist simultaneously in the space of the brain’s EM field, feel like.

Life insurers and those offering income protection and permanent disability insurance will be banned from using genetic testing to refuse cover, or hike up charges, for a range of insurance products.

The federal government announced on Tuesday it would ban the practice that saw consumers discriminated against if they disclosed the results of genetic tests that predict their likelihood of an inherited disease.

It comes after consultation to address genetic discrimination in life insurance earlier this year. More than 1,000 submissions were received with 97 per cent supporting a total ban.