Lifeboat Foundation

Altered dystrophin expression was found in some tumors and recent studies identified a developmental onset of Duchenne muscular dystrophy (DMD). Given that embryogenesis and carcinogenesis share many mechanisms, we analyzed a broad spectrum of tumors to establish whether dystrophin alteration evokes related outcomes. Transcriptomic, proteomic, and mutation datasets from fifty tumor tissues and matching controls (10,894 samples) and 140 corresponding tumor cell lines were analyzed. Interestingly, dystrophin transcripts and protein expression were found widespread across healthy tissues and at housekeeping gene levels. In 80% of tumors, DMD expression was reduced due to transcriptional downregulation and not somatic mutations. The full-length transcript encoding Dp427 was decreased in 68% of tumors, while Dp71 variants showed variability of expression.

A killer plant fungus infected a human and caused flu-like symptoms in what researchers say is a world-first case.

Chondrostereum purpureum causes silver leaf disease in flora, most commonly in species of rose.

Spread by airborne spores, it is named such because it gradually turns leaves silver — and is often fatal.

Continue reading “Killer plant fungus Chondrostereum purpureum infects man in India in ‘world-first case’” »

Energy production in nature is the responsibility of mitochondria and chloroplasts, and is crucial for fabricating sustainable, synthetic cells in the lab. Mitochondria are “the powerhouses of the cell,” but are also one of the most complex intracellular components to replicate artificially.

In Biophysics Reviews, by AIP Publishing, researchers from Sogang University in South Korea and the Harbin Institute of Technology in China identified the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts.

“If scientists can create artificial mitochondria and chloroplasts, we could potentially develop synthetic cells that can generate energy and synthesize molecules autonomously. This would pave the way for the creation of entirely new organisms or biomaterials,” author Kwanwoo Shin said.

In this weeks episode of The Futurists, cognitive scientist and AI researcher Ben Goertzel joins the hosts to talk the likely path to Artificial General Intelligence. Goertzel is the founder of SingularityNet, Chairman at OpenCog Foundation, and previously as the Chief Scientist at Hanson Robotics he helped create Sophia the robot. Goertzel is on a different level, get ready to step up. Follow @bengoertzel.

ABOUT SHOW
Subscribe and listen to TheFuturists.com Podcast where hosts Brett King and Robert TerceK interview the worlds foremost super-forecasters, thought leaders, technologists, entrepreneurs and futurists building the world of tomorrow. Together we will explore how our world will radically change as AI, bioscience, energy, food and agriculture, computing, the metaverse, the space industry, crypto, resource management, supply chain and climate will reshape our world over the next 100 years. Join us on The Futurists and we will see you in the future!

Continue reading “The Futurists Podcast — Cognitive AGI& Robotics with Ben Goertzel” »

One can only hope.

A former Google engineer has just predicted that humans will achieve immortality in eight years, something more than likely considering that 86% of his 147 predictions have been correct.

Ray Kurzweil visited the YouTube channel Adagio, in a discussion on the expansion of genetics, nanotechnology and robotics, which he believes will lead to age-reversing ‘nanobots’.

Continue reading “Former Google engineer predicts humans will achieve immortality within eight years” »

The actor Bruce Willis was diagnosed with aphasia in April 2022—updated in February 2023 to frontotemporal dementia (FTD). Now, a major advancement is helping develop new treatments for some people with motor neuron diseases, including FTD and ALS, possibly including a nasal spray that could help prevent the genetic disease.

I dunno if anyone has seen this. As a former Linux user, I’ve been an Nvidia fan for a long time and now they’ve gone on from games and Bitcoin mining. Sorry if this is a double post. I’m on my way out the door for my mom’s Dr appointment. I always worry I’ll double post by accident.

NVIDIA’s Jensen Huang just announced a set of revolutionary new Artificial Intelligence Models and Partnerships at GTC 2023. NVIDIA has always been one of, if not the most important company in the AI Industry by creating the most powerful AI hardware to date. Among them the A100 and future H100 GPU’s which are powering GPT-4 from OpenAI, Midjourney and everyone else. This gives them a lot of power to jump into the AI race themselves and allows them to surpass and beat the currently best AI models from Large Language Models and Image Generation with software like Omniverse and Hardware like the DGX H100 Supercomputer and Grace CPU’s.
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TIMESTAMPS:
00:00 NVIDIA enters the AI Industry.
01:43 GTC 2023 Announcements.
04:48 How NVIDIA Beat Every Competitor at AI
07:40 Running High End AI Locally.
10:20 What is NVIDIA’s Future?
13:05 Accelerating Future.
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Technology is improving at an almost exponential rate. Robots are learning to walk & think, Brain Computer Interfaces are becoming commonplace, new Biotechnology is allowing for age reversal and Artificial Intelligence is starting to surpass humans in many areas. Follow FutureNET to always be up to date on what is happening in the world of Futuristic Technology and Documentaries about humanities past achievements.
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#nvidia #ai #gtc

Macromolecular machines acting on genes are at the core of life’s fundamental processes, including DNA replication and repair, gene transcription and regulation, chromatin packaging, RNA splicing, and genome editing. Here, we report the increasing role of computational biophysics in characterizing the mechanisms of “machines on genes”, focusing on innovative applications of computational methods and their integration with structural and biophysical experiments. We showcase how state-of-the-art computational methods, including classical and ab initio molecular dynamics to enhanced sampling techniques, and coarse-grained approaches are used for understanding and exploring gene machines for real-world applications.

A recently patented genome editing tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. The approach combines elements of CRISPR and prime editing with a pair of enzymes designed to enable the integration of large segments of DNA without incurring double-stranded DNA breaks.

U.S. Patent No. 11,572,556, assigned to MIT, covers systems, methods, and compositions for programmable addition via site-specific targeting elements (PASTE). The patent describes site-specific integration of a nucleic acid into a genome, using a CRISPR–Cas9 nickase fused to a reverse transcriptase (RT) and a serine integrase. These enzymes target specific genome sequences known as attachment sites, binding to them before integrating their DNA payload.

PASTE can insert DNA fragments as large as 50,000 base pairs, which puts it on a different plane compared to other genome editing tools such as prime editing.