Lifeboat Foundation

The findings suggest that adenosine base editing raised the expression of fetal hemoglobin to higher, more stable, and more uniform levels than other genome editing technologies that use CRISPR/Cas9 nuclease in human hematopoietic stem cells.

“Ultimately, we showed that not all genetic approaches are equal,” said Jonathan Yen, PhD, genome engineering group director at St. Jude Children’s Research Hospital. “Base editors may be able to create more potent and precise edits than other technologies. But we must do more safety testing and optimization.”

SCD and beta-thalassemia are blood disorders caused by mutations in the gene encoding hemoglobin affecting millions of people. Restoring gene expression of an alternative hemoglobin subunit active in a developing fetus has previously shown therapeutic benefit in SCD and beta-thalassemia patients. The researchers wanted to find and optimize genomic technology to edit the fetal hemoglobin gene.

Continue reading “Base Editing Beats Other Genome Editing Strategies for Treating Sickle Cell Disease” »

Trading activity in August has fallen by over 94 percent compared to March this year.

Far from its all-time high values, cryptocurrency Bitcoin is failing to attract interest from traders, as per a recent report of trading volumes at crypto exchanges, CNBC

The interest in Bitcoin surged during the COVID-19 pandemic as the world economy came to a grinding halt. As investors looked to park their funds in rising assets, Bitcoin became a top favorite, and its valuation soared to all-time highs of over $68,000.

Over $2772.7 billion, that’s how far global programmatic advertising display spend will march by 2028. In realms where consumer habits gravitate toward online experiences and cross-channel digital content consumption, the share of programmatic advertising in the total media-buying spend reaches 80%.

Meanwhile, the worth of the overall adtech market is expected to hit $2.9 trillion by 2031; it is heavily oversaturated, meaning that everyone striving to enter it should know how to do it the right way while saving resources but still offering competitive tech.

The adtech market is booming; however, it is not that it doesn’t face challenges. On the contrary, the last couple of years have been giving it a hard time—first with tightening privacy regulations, then with cookies crumbling, and finally with a pandemic period full of uncertainty.

How much time elapses between a blow to the head and the start of damage associated with Alzheimer’s disease?

A device that makes it possible to track the effects of concussive force on a functioning cluster of brain cells suggests the answer is in hours. The “traumatic brain injury (TBI) on a chip” being developed at Purdue University opens a window into a cause and effect that announces itself with the passage of decades but is exceedingly difficult to trace back to its origins.

“We’re basically creating a miniature brain that we can hit and then study,” said Riyi Shi, lead researcher and the Mari Hulman George Endowed Professor of Applied Neuroscience in Purdue University’s College of Veterinary Medicine. “We know there’s a link between TBI and Alzheimer’s; that’s well established in clinical observation. But teasing out the basic essential pathway is not easy. With the TBI on a chip, we’re able to test a lot of hypotheses that would be very difficult to do in living animals.”

The Winer lab has helped establish three sub-specialties that are fueling the field.

The experimental interface allows the patient to communicate through a digital avatar, and it’s faster than her current system.

This is good news! The article says this could lead to treatment of other cancers.

A particularly aggressive form of childhood cancer that forms in muscle tissue might have a new treatment option on the horizon.

Scientists have successfully induced rhabdomyosarcoma cells to transform into normal, healthy muscle cells. It’s a breakthrough that could see the development of new therapies for the cruel disease, and it could lead to similar breakthroughs for other types of human cancers.

Continue reading “Aggressive Cancer Cells Transformed Into Healthy Cells in Breakthrough” »

#ted.
#wifi.
#internet.

Continue reading “LiFi — This is the Fastest Internet in the World (224GBPS) — Easiest Explanation Ever!” »

Rohit Chikkaraddy/ University of Birmingham.

Mid-infrared, as the name suggests, lies between the infrared spectrum’s near and far wavelengths, just outside those of visible light. The mid-infrared spectrum has gained particular importance as it has been useful for multiple applications ranging from military to environmental and medical treatments and studying celestial objects.