Lifeboat Foundation

No damage caused by strong light, no artificial dyes or fluorescent tags needed.

The insides of living cells can be seen in their natural state in greater detail than ever before using a new technique developed by researchers in Japan. This advance should help reveal the complex and fragile biological interactions of medical mysteries, like how stem cells develop or how to deliver drugs more effectively.

“Our system is based on a simple concept, which is one of its advantages,” said Associate Professor Takuro Ideguchi from the University of Tokyo Research Institute for Photon Science and Technology. The results of Ideguchi’s team were published recently in Optica, the Optical Society’s research journal.

The coronavirus has killed dozens of federal prisons and infected more than 6,000. Prisoners say they have been stuck in grim conditions that make social distancing impossible. To support their claims, some prisoners have used contraband cell phones that have been smuggled into prisons to post videos on Facebook and other social media sites.

VICE News contacted one of the prisoners, 34-year-old Aaron Campbell, held at a federal prison in Ohio, who said he was punished for making his video by being sent to solitary confinement. In a letter, Campbell said officials told him he would not face additional discipline if he issued a statement saying the video was fake. He refused. (The BOP did not respond to questions about his allegations.)

Continue reading “Prisoners Are Using Smuggled Cellphones to Show the Coronavirus Nightmare Behind Bars” »

A neuroscientist’s neon pink arm cast led him and fellow researchers at Washington University School of Medicine in St. Louis to discover previously undetected neuronal pulses in the human brain that activate after an immobilizing illness or injury.

Via Jacob Gunn Glanville

Here’s the Forbes article on our program. Press release and some media to follow. We will be publishing our manuscript within a week to bioarxiv.

Jacob Glanville is an admirer of the human immune system — but he thinks we can do better.

Continue reading “Netflix ‘Pandemic’ Star Just Showed His Covid-19 Antibody Drug Works In Hamsters. How Quickly Could It Treat Humans?” »

A rejuvenation roadmap, and some info on Rejuvenate Bio.

Ray Kurzweil predicted the Technological Singularity will be reached in 2045. This actually means there will be strong AI, something like AGI that is 1 billion times more capable than the human brain in many aspects.

The Madison, Wisconsin-based startup Phoenix has scouted a team of nuclear elites for a new frontier: small reactors that can revolutionize medical imaging, munitions scanning, and even non-destructive testing for quality assurance.

And in the longer term, scientists say training people to run neutron generators helps to familiarize and speed up the future of nuclear fusion.

Chimeric antigen receptor (CAR) T cells have transformed the treatment of refractory blood cancers. These genetically engineered immune cells seek out and destroy cancer cells with precision. Now, scientists at Memorial Sloan Kettering are deploying them against other diseases, including those caused by senescence, a chronic “alarm state” in tissues. The scope of such ailments is vast and includes debilitating conditions, such as fibrotic liver disease, atherosclerosis, and diabetes.

Key to the success of CAR T cell therapy has been finding a good target. The first US Food and Drug Administration-approved CAR T cells target a molecule on the surface of blood cancers called CD19. It is present on cancer cells but few other normal cells, so side effects are limited.

Taking their cue from this prior work, a team of investigators including Scott Lowe, Chair of the Cancer Biology and Genetics Program in the Sloan Kettering Institute, and Michel Sadelain, Director of the Center for Cell Engineering at MSK, along with their trainees Corina Amor, Judith Feucht, and Josef Leibold, sought to identify a target on senescent cells. These cells no longer divide, but they actively send “help me” signals to the immune system.

There’s a deluge of apps that detect your covid-19 exposure, often with little transparency. Our Covid Tracing Tracker project will document them.

By

• Patrick Howell O’Neill archive page
• Tate Ryan-Mosley archive page
• Bobbie Johnson archive page

The cocktail, now named REGN-COV2, consists of two antibodies—REGN10933 and REGN10987—that are designed to bind non-competitively to the receptor binding domain of SARS-CoV-2’s spike protein. Regeneron says that such binding diminishes the ability of mutant viruses to escape treatment—with details from preclinical research to be published in upcoming research studies.

Regeneron Pharmaceuticals said today it has launched the first clinical trial of its dual-antibody “cocktail” designed to both prevent and treat COVID-19, as well as prevent viral escape. The cocktail, now named REGN-COV2, consists of two antibodies—REGN10933 and REGN10987—that are designed to bind non-competitively to the receptor binding domain of SARS-CoV-2’s spike protein. [Regeneron].