Lifeboat Foundation

The embryos, which were not allowed to develop past 28 days of age, move researchers a small step closer to perhaps growing human organs for medical transplant.

Every hour, six people in the United States are added to the national waiting list for organ transplants—and each day, 22 people on the list die waiting. In the U.S. alone, more than a hundred thousand people need heart transplants each year, but only about 2,000 receive one.

In response, researchers are working to artificially expand the organ supply. Some are trying to 3D print organs in the lab. Others are working on artificial, mechanical organs. And some are making chimeras—hybrids of two different species—in the hopes of growing human organs in pigs or sheep.

Could speed up healing.

Wound healing in mammalian skin often results in fibrotic scars, and the mechanisms by which original nonfibrotic tissue architecture can be restored are not well understood. Here, Wei et al. have shown that pharmacological activation of the nociceptor TRPA1, which is found on cutaneous sensory neurons, can limit scar formation and promote tissue regeneration. They confirmed the efficacy of TRPA1 activation in three different skin wounding mouse models, and they also observed that localized activation could generate a response at distal wound sites. TRPA1 activation induced IL-23 production by dermal dendritic cells, which activated IL-17–producing γδ T cells and promoted tissue regeneration. These findings provide insight into neuroimmune signaling pathways in the skin that are critical to mammalian tissue regeneration.

Adult mammalian wounds, with rare exception, heal with fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation and restore the original tissue structures. We show in three adult mouse models that pharmacologic activation of the nociceptor TRPA1 on cutaneous sensory neurons reduces scar formation and can also promote tissue regeneration. Local activation of TRPA1 induces tissue regeneration on distant untreated areas of injury, demonstrating a systemic effect. Activated TRPA1 stimulates local production of interleukin-23 (IL-23) by dermal dendritic cells, leading to activation of circulating dermal IL-17–producing γδ T cells. Genetic ablation of TRPA1, IL-23, dermal dendritic cells, or γδ T cells prevents TRPA1-mediated tissue regeneration.

A plan to release over 750 million genetically modified mosquitoes into the Florida Keys in 2021 and 2022 received final approval from local authorities, against the objection of many local residents and a coalition of environmental advocacy groups. The proposal had already won state and federal approval.

“With all the urgent crises facing our nation and the State of Florida — the Covid-19 pandemic, racial injustice, climate change — the administration has used tax dollars and government resources for a Jurassic Park experiment,” said Jaydee Hanson, policy director for the International Center for Technology Assessment and Center for Food Safety, in a statement released Wednesday.

“Now the Monroe County Mosquito Control District has given the final permission needed. What could possibly go wrong? We don’t know, because EPA unlawfully refused to seriously analyze environmental risks, now without further review of the risks, the experiment can proceed,” she added.

In this video, Elon Musk demonstrates a prototype brain–computer interface chip – implanted in a pig – that his company, Neuralink, has been working on. The device could one day be used by humans to augment their abilities.

Founded in 2016, the Neuralink Corporation remained highly secretive about its work until July 2019, when Musk presented his concept at the California Academy of Sciences. It emerged that he planned to create brain–machine interfaces (BMIs) not only for diseased or injured patients, but also healthy individuals who might wish to enhance themselves.

Yesterday, in a livestream event on YouTube, Musk unveiled a pig called Gertrude with a coin-sized chip in her brain. Simpler and smaller than the original revealed last year, the read/write link device can nevertheless pack 1,024 channels with megabit wireless data rate and all-day battery life. This latest prototype – version 0.9 – has now been approved as an FDA breakthrough device, allowing it to be used in limited human trials under the US federal guidelines for testing medical devices. The chip is removable, Musk explained, as he showed another pig called Dorothy, who no longer had the implant and was healthy, happy and indistinguishable from a normal pig.

Summary: Neuroimaging predicts whether a person with OCD will respond to stress-reduction therapy or exposure-based therapy best. Analyzing brain activity may help to provide tailored treatments to individuals suffering from OCD.

Source: Michigan Medicine

New research could improve the odds that people with obsessive-compulsive disorder will receive a therapy that really works for them – something that eludes more than a third of those who currently get OCD treatment.

https://youtube.com/watch?v=OyVGiJacQqI

The tactic has become widespread on battlefields overseas and now appears to be proliferating to organized crime.

Sixty feet beneath the surface of the Caribbean Sea, aquanaut Fabien Cousteau and industrial designer Yves Béhar are envisioning the world’s largest underwater research station and habitat.

The pair have unveiled Fabien Cousteau’s Proteus, a 4,000-square-foot modular lab that will sit under the water off the coast of Curaçao, providing a home to scientists and researchers from across the world studying the ocean — from the effects of climate change and new marine life to medicinal breakthroughs.

Designed as a two-story circular structure grounded to the ocean floor on stilts, Proteus’ protruding pods contain laboratories, personal quarters, medical bays and a moon pool where divers can access the ocean floor. Powered by wind and solar energy, and ocean thermal energy conversion, the structure will also feature the first underwater greenhouse for growing food, as well as a video production facility.

A worldwide pandemic, something that has not occurred for over 100 years is, without question, the story of the year. The impact and ripple effect may take years before analysts are comfortable with knowing what exactly happened. In an amazing effort to curb Covid-19 and keep world economics intact, the United States and foreign countries took extraordinary measures, most of which where thought of, designed, and implemented in days or weeks. There will be plenty of critics.

If the world emerges from this pandemic in the next 6 to 18 months, it will be because of a rapid response. Inflation could be an issue, yet monetary policy enacted was necessary to keep the world from falling into a depression. The issues that won’t be talked about are ones that never happened, thanks to aggressive government action.

In the commodity world, much like the equities, great uncertainty leads to wild volatility. Energy prices dropping into negative territory and milk prices dropping sharply only to rally to all-time new highs illustrate the dichotomy of just how demand (or perception thereof) ebbs and flows at unprecedented speeds. These are just two examples of many markets that experienced extreme price moves.

Summary: A newly designed synthetic compound could act as a prototype for a novel class of drugs to treat neurological damage.

Source: DZNE

Researchers from the German Center for Neurodegenerative Diseases (DZNE), UK and Japan have developed a neurologically acting protein and tested it in laboratory studies. In mice, the experimental compound ameliorated symptoms of certain neurological injuries and diseases, while on the microscopic level it was able to establish and repair connections between neurons. This proof-of-principle study suggests that biologics, which act on neuronal connectivity, could be of clinical use in the long term. The results are published in the journal Science.