Lifeboat Foundation

Emerging and reemerging infections present an ever-increasing challenge to global health. Here, we report a nanoparticle-enabled smartphone (NES) system for rapid and sensitive virus detection. The virus is captured on a microchip and labeled with specifically designed platinum nanoprobes to induce gas bubble formation in the presence of hydrogen peroxide. The formed bubbles are controlled to make distinct visual patterns, allowing simple and sensitive virus detection using a convolutional neural network (CNN)-enabled smartphone system and without using any optical hardware smartphone attachment. We evaluated the developed CNN-NES for testing viruses such as hepatitis B virus (HBV), HCV, and Zika virus (ZIKV). The CNN-NES was tested with 134 ZIKV-and HBV-spiked and ZIKV-and HCV-infected patient plasma/serum samples. The sensitivity of the system in qualitatively detecting viral-infected samples with a clinically relevant virus concentration threshold of 250 copies/ml was 98.97% with a confidence interval of 94.39 to 99.97%.

See allHide authors and affiliations.

Smartphone systems can also benefit from the recent unprecedented advancements in nanotechnology to develop diagnostic approaches. Catalysis can be considered as one of the popular applications of nanoparticles because of their large surface-to-volume ratio and high surface energy (11–16). So far, numerous diagnostic platforms for cancer and infectious diseases have been developed by substituting enzymes, such as catalase, oxidase, and peroxidase with nanoparticle structures (17–20). Here, we adopted the intrinsic catalytic properties of platinum nanoparticles (PtNPs) for gas bubble formation to detect viruses on-chip using a convolutional neural network (CNN)–enabled smartphone system.

On today’s episode we are going to continue our virtual global road trip over to the country of South Africa, to the Soweto township of the city of Johannesburg, and meet up with Ms. Sibongile Mongadi, Founder of Uku’hamba Pty Ltd, a start-up company that focuses on biotechnology and healthcare manufacturing with a goal of improving lives of amputees across Africa.

Uku’hamba is a 100% black youth women owned company and Uku’hamba means “To Walk” in Zulu.

Continue reading “Sibongile Mongadi, STEM Innovator, Founder, Uku’hamba, Improving The Lives Of Amputees Across Africa” »

Summary: Researchers have identified a direct cellular interaction between the nervous system and the immune system. Pain sensing neurons around the lymph nodes can modulate lymph node activity.

Source: Broad Institute.

The nervous and immune systems have long been thought to be separate entities in the body, but new research has uncovered a direct cellular interaction between the two. Scientists from Harvard Medical School, the Broad Institute of MIT and Harvard, MIT, and the Ragon Institute of MGH, MIT and Harvard have found that pain-sensing neurons surround lymph nodes in mice, and can modulate the activity of these small organs, which are key parts of the immune system.

Summary: YKL-40 may be a key player in circadian rhythm disruptions associated with Alzheimer’s disease.

Source: WUSTL

Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s and circadian dysfunction is not well understood.

Anyone who has ever worked on a team knows that their strength lies in coordination and a shared vision. However, it is not always easy to provide that coordination and shared vision, and any team that lacks that cohesiveness becomes more of a hindrance than a help.

Science is not immune to the difficulties of running effective teams. There is plenty to be gained from more coordination between differing silos and physical locations. Recently a meeting in Chile prompted a group of scientists to propose a plan to change that. The result is a white paper that points out the potential benefits of coordinating ground, orbital and in situ based observations of objects. But more importantly, it suggests a different path forward where all of the space science community can benefit from the type of coordinated output that can only come from a cohesive team.

The suggested path laid out in the white paper began at the Planets2020 conference in Chile, hosted by the ALMA observatory. The meeting took place back in March, right before the Coronavirus outbreak began to restrict travel. At the conference, there was a significant amount of discussion focused on the capabilities of different Earth and space based observing platforms. The intention was to learn more about missions that coordinated ground and space-based observations, and to flesh out future ideas of how to replicate that coordination with new and existing platforms to make the best of their different capabilities. The lead author of the white paper, Vincent Kofman, a research chemist at Goddard Space Flight Center, took on that the task of coordinating that team and produced a paper that clearly lays out a better way to perform observations.

Johnson & Johnson said Thursday that late-stage clinical trials for its coronavirus vaccine are now fully enrolled, and expects to release initial data on the shot’s effectiveness by the end of January.

The pharmaceutical company’s single-dose vaccine is in Phase 3 clinical trials that are now fully enrolled, and is already being reviewed by Health Canada.

In a press release, the U.S. Army announced that initial Mobile Protected Firepower (MPF) prototypes arrived at Fort Bragg, North Carolina. The preproduction MPF vehicles will be put through their paces by paratroopers from the Army’s 82 Airborne.

“We are incredibly excited to see the MPF platform entering into this phase,” an Army Ground Combat Systems official stated, explaining that the “MPF represents an innovative and aggressive approach to system acquisition. The beginning of our SVA (soldier vehicle assessment) in January illustrates how hard the teams are working to keep the major events of this program on schedule,” despite the ongoing pandemic.

The Army awarded two initial prototyping contracts to both BAE Systems and General Dynamics back in 2018. The contracts, worth $376 million each, covered a total of 504 final production Mobile Protected Firepower vehicles, with initial deliveries scheduled for 2025.

“BAT said KBP had cloned a portion of the genetic sequence of coronavirus and developed a potential antigen, which is then inserted into tobacco plants for reproduction.”

😲😲😲

While large pharmaceutical companies are already producing vaccines, [the company British American Tobacco] believes its own can be produced in six weeks, compared with the several months it takes using conventional methods.

Continue reading “COVID vaccine made from GMO tobacco? It’s now in human trials” »

“The research was conducted by overexpressing two different genes, the AVP1 and OsSIZ1.”

😯😯😯

One group of Texas Tech University researchers has found a way to double fiber yield for cotton in semi-arid areas like that of West Texas, where drought, heat and salinity are working against farmers.

Continue reading “Tweaking two genes in cotton doubles crop yields—and may do the same in wheat, rice and corn” »