Lifeboat Foundation

Antisense oligonucleotide therapy works by altering the RNA, the messenger that carries instructions from your DNA to crank out proteins.

An article in Nature Reviews Neurology describes antisense oligonucleotides as “short, synthetic, single-strand” molecules, which can alter RNA to cause protein creation to be reduced, enhanced, or modified.

In the Penn study, the targeted protein was created by the mutated LCA gene.

The researchers managed to do this by detecting a failure in the immune system of the brain which can be used against the deadly cancer.

Total semiconductor shipments including shipments of ICs as well as optoelectronics, sensor/actuator and discrete (O-S-D) devices are forecast to rise 13% to a record high of 1.135 trillion units in 2021, according to IC Insights. It would mark the third time that semiconductor units have surpassed one trillion units in a calendar year — the first time being in 2018.

The 13% increase follows a 3% increase in 2020 as the COVID-19 pandemic was wreaking havoc across many segments of the economy, IC Insights indicated. From 1978, when 32.6 billion units were shipped, through 2021, the compound annual growth rate (CAGR) for semiconductor units is forecast to be 8.6%. The strong CAGR also demonstrates that new market drivers continue to emerge that fuel demand for more semiconductors.

Between 2004 and 2007, semiconductor shipments broke through the 400-, 500-, and 600-billion unit levels before the global financial meltdown led to a steep decline in semiconductor shipments in 2008 and 2009. Unit growth rebounded sharply in 2010 with a 25% increase and surpassed 700 billion devices that year. Another strong increase in 2017 (12% growth) lifted semiconductor unit shipments beyond the 900-billion level before the one-trillion mark was surpassed in 2018, IC Insights said.

Aging is maleable and can be intervened to slow down and even reverse it.
Several experiments in animal models have shown that certain gene therapies as well as interventions via partial cellular reprograming can significantly extend healthspan and lifespan in mice and other model organisms.

An article published on December 30, 2020 in Fortune magazine, reaches the following conclusions:
* Without treatments to slow or reverse aspects of biological aging, an aging population means we are in for a health care cost tsunami.
* The most exciting opportunity for such an improvement in health productivity is to understand and address the biology of aging.
* There is promising scientific research on reversing aspects of aging, some of which is not far from clinical application.
* While all this research represents thrilling progress, we invest far too little in research that could help us go further in understanding and treating aging.

Continue reading “Aging isn’t nice — Let’s bring world leaders to the quest of solving it” »

Neuralink, co-founded by Elon Musk in 2016, has revealed a macaque with chips embedded on each side of its brain, playing a mind-controlled version of the 1972 video game, Pong.

Although established in 2016, Neuralink remained secretive about its work until July 2019, when Musk presented his concept for a new brain–machine interface (BMI). Not only would this help physically diseased or injured people, Musk believed it could also treat mental illness – and even be used by healthy individuals who might wish to enhance themselves.

A prototype in August 2020 demonstrated the Neuralink technology in a pig. This coin-sized chip, featuring a read/write link, contained 1024 channels with a wireless megabit data rate and all-day battery life. Brain signals conveying the pig’s sense of smell could be seen in real time. The FDA had by then approved it as a breakthrough device, allowing use in limited human trials under the US federal guidelines for testing medical devices.

Summary: Researchers have identified specific anti-bodies that can have a neutralizing effect on the virus responsible for tick-borne encephalitis. Preliminary response in using the anti-bodies in mice has proven affected in preventing TBE. It is hoped a vaccine candidate for TBE can be developed for humans.

Source: Rockefeller University.

Tick-borne encephalitis is a disease just as nasty as it sounds. Once bitten by an infected tick, some people develop flu-like symptoms that resolve quietly but leave behind rampant neurological disease–brain swelling, memory loss, and cognitive decline. Cases are on the rise in Central Europe and Russia with some 10000 incidents reported each year. Vaccines can provide protection, but only for a limited time. There is no cure.

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and.
can be corrected by dietary cysteine and glycine supplementation:
https://pubmed.ncbi.nlm.nih.gov/21795440/

Continue reading “Glutathione Restoration Improves Hallmarks Of Aging in Older Adults” »

U.S. policymakers have spent trillions of dollars to mitigate the effects of Covid-19. But the answer to preventing the next pandemic altogether lies elsewhere.

Researchers in China have designed a new bio-hybrid microbot, able to cross the blood-brain barrier and deliver drugs directly to brain tumours.