Lifeboat Foundation

Mice who ate a diet high in fat and cholesterol were more likely to see their hair turn from black to white and experience hair loss. The diet also appeared to cause inflammation of the skin.

In the first stage of the study, the researchers genetically modified mice to develop atherosclerosis, a condition in which fat deposits form in the arteries.

They then fed mice either a Western diet high in fat and cholesterol or untreated rat chow from the age of 12 to 20 weeks. As expected, the mice who consumed the Western diet saw their hair turn white and fall out, and develop skin lesions. And the longer the mice ate the diet, the worse their symptoms became. By week 36, three quarters of the animals had skin lesions.

New research^[1] presented at the 29th EADV Congress, EADV Virtual, shows that socks coated in zinc oxide nanoparticles (ZnO-NPs) can prevent bromodosis (foot odor) and pitted keratolysis (bacterial infection causing smelly feet), reducing the negative impact this embarrassing condition has on quality of life.^[2]

Developed by the Royal Thai Airforce, the ZnO-NP-coated socks were trialed in a real-life setting by researchers at Siriraj Hospital, Mahidol University in Thailand. They found that the antibacterial efficacy of ZnO-NPs, along with its safety and compatibility with human skin, makes it the perfect compound to incorporate into textiles, including socks, to prevent unpleasant foot odor.

The double-blinded, randomized, controlled trial was conducted with 148 cadets at the Thai Naval Rating School. Bromodosis and pitted keratolysis are a common complaint in military personnel, with foot lesions, including pitted keratosis, occurring in over a third of naval cadets in Thailand (38.5%).^[2]

Hundreds of American hospitals are being targeted in cyberattacks by the same Russian hackers who American officials and researchers fear could sow mayhem around next week’s election.

The attacks on American hospitals, clinics and medical complexes are intended to take those facilities offline and hold their data hostage in exchange for multimillion-dollar ransom payments, just as coronavirus cases spike across the United States.

“We expect panic,” one hacker involved in the attacks said in Russian during a private exchange on Monday that was captured by Hold Security, a security company that tracks online criminals.

The result is a science park and university campus that offers degrees at all levels. It hosts more than 300 labs and advanced research equipment, such as the SOLEIL synchrotron. About 100 companies and 6 of France’s public research organizations, including the national research agency CNRS, have a presence there. That combination — of the university with national facilities — is powerful, says Price. The park accounts for an estimated 15% of France’s public and private research. About 30,000 people work or study at Saclay, and this is projected to rise to 80,000 by 2030.

The lab has no overall scientific project, and has added an extra layer of management, says Fayard, although he concedes that the coronavirus pandemic has complicated the lab’s first months. “I fear the lab will have to work hard not to fall between two stools — it is too big to be efficient, but not big enough to invest alone in major local infrastructures.”

But Oliver Brüning, a particle physicist at CERN, Europe’s particle physics lab near Geneva, Switzerland, who spent time working at LAL, says he thinks the new lab has greater weight and influence than did LAL alone.

Continue reading “How France overcame the odds to build a research mega-campus” »

Angelika Amon, professor of biology and a member of the Koch Institute for Integrative Cancer Research, died on Oct. 29 at age 53, following a two-and-a-half-year battle with ovarian cancer.

“Known for her piercing scientific insight and infectious enthusiasm for the deepest questions of science, Professor Amon built an extraordinary career – and in the process, a devoted community of colleagues, students and friends,” MIT President L. Rafael Reif wrote in a letter to the MIT community.

“Angelika was a force of nature and a highly valued member of our community,” reflects Tyler Jacks, the David H. Koch Professor of Biology at MIT and director of the Koch Institute. “Her intellect and wit were equally sharp, and she brought unmatched passion to everything she did. Through her groundbreaking research, her mentorship of so many, her teaching, and a host of other contributions, Angelika has made an incredible impact on the world — one that will last long into the future.”

“The logistics of clinical testing don’t let you sample everybody, but sewage does sample everybody.”-Steve Hrudey.

Raw sewage being flushed into Alberta’s municipal wastewater plants could help public health officials better track — and predict — the spread of COVID-19.

A team of Alberta scientists has joined a growing international effort to sample wastewater for traces of SARS-CoV-2, the virus responsible for the disease.

Continue reading “Alberta excrement being tested for COVID-19 as researchers refine sewage surveillance” »

A small energy harvesting device that can transform subtle mechanical vibrations into electrical energy could be used to power wireless sensors and actuators for use in anything from temperature and occupancy monitoring in smart environments, to biosensing within the human body.

In research recently published online in the Journal of Micromechanics and Microengineering, engineers at Rensselaer Polytechnic Institute developed a predictive model for such a device, which will allow researchers to better understand and optimize its functionalities.

“Sooner or later these harvesters will replace batteries, reducing associated environmentally hazardous waste and maintenance costs,” said Diana-Andra Borca-Tasciuc, a professor of mechanical, aerospace, and nuclear engineering at Rensselaer, who led this research effort.

Moderna is prepping for the global launch of its potential coronavirus vaccine, already taking in $1.1 billion in deposits from governments awaiting the potentially lifesaving drug, the biotech firm said Thursday in its third-quarter earnings report.

The Cambridge, Massachusetts-based company said it was in ongoing talks with the World Health Organization-backed COVAX initiative on a tiered pricing proposal for its potential vaccine, which it’s tentatively calling mRNA-1273. It already has supply agreements in North America, the Middle East and in other regions of the world.

“We are actively preparing for the launch of mRNA-1273 and we have signed a number of supply agreements with governments around the world,” Moderna CEO Stephane Bancel said in a press release. “Moderna is committed to the highest data quality standards and rigorous scientific research as we continue to work with regulators to advance mRNA-1273.”

Many of the fundamental principles in biology and essentially all pathways regulating development were identified in so-called genetics screens. Originally pioneered in the fruit fly Drosophila and the nematode C. elegans, genetic screens involve inactivation of many genes one by one. By analyzing the consequences of gene loss, scientists can draw conclusions about its function. This way, for example, all genes required for formation of a brain can be identified.

Genetic screens can routinely be carried out in flies and worms. In humans, a wealth of knowledge exists about genetic disorders and the consequences of disease-relevant mutations, but their systematic analysis was impossible. Now, the Knoblich lab at IMBA has developed a groundbreaking technique allowing hundreds of genes to be analyzed in parallel in human tissue. They named the new technology CRISPR-LICHT and published their findings in the journal Science.

By using cerebral organoids, a 3D cell culture model for the human brain developed in Jürgen Knoblich’s group at IMBA, hundreds of mutations can now be analyzed for their role in the human brain using CRISPR-LICHT.