Lifeboat Foundation

Not sure how interesting this will be to people who know a lot on aging/longevity research.

A team of researchers at Brigham and Women’s Hospital and Harvard Medical School have found evidence of mouse and human germline cells resetting their biological age. In their paper published in the journal Science Advances, the group describes their study of the aging process in germline cells and what they found by doing so.

As animals grow older, all of the cells in their body replicate themselves repeatedly. As the process continues, errors in replicating and other external factors (such as exposure to pollutants) lead to gradual decay in cell quality, which is all part of the natural aging process. In this new effort, the researchers have found evidence showing that germline cells have a mechanism for resetting this process, allowing offspring to reset their aging clocks.

Continue reading “Mouse and human germline cells appear to reset their biological age” »

A team of biohackers is on a David-versus-Goliath mission to make insulin affordable to an increasing number of diabetics.

The human body contains hundreds of different types of cells, with stem cells working like blank canvases that can be adapted and reproduced to help our tissues grow and repair themselves. However, once hijacked, the same kind of cell proliferation can be damaging, as happens in cancer tumors.

Scientists have now discovered a new resting phase for neuroepithelial cells — the stem cells of the central nervous system — which appears to put them in a kind of dormancy. If we can work out how to apply this to cancer cells too, we could get to the stage of being able to put brain tumors to ‘sleep’.

“The primary feature of any cancer is that the cells are proliferating,” says biomedical engineer Christopher Plaisier, from Arizona State University. “If we could get in there and figure out what the mechanisms are, that might be a place to slow them down.”

WHO certifies country free of the deadly disease after 3 years without local transmission.

Walmart will offer a less expensive private label version of analog insulin for diabetes patients who struggle to afford their medication, the retail and pharmacy giant said June 29.

Novo Nordisk will manufacture the insulin, called ReliOn NovoLog. Walmart said it will become available at Walmart pharmacies the week of June 27 and at Sam’s Club pharmacies in mid-July.

A vial of ReliOn NovoLog will cost $72.88, and a package of prefilled pens will cost $85.88. Walmart said these products will save patients between 58 and 75 percent of the price of other insulin products on the market.

Papers referenced in the video:

Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase.
https://pubmed.ncbi.nlm.nih.gov/31425154/

Continue reading “Aspartate Aminotransferase: What’s Optimal, And Can It Be Improved?” »

The ability to precisely control the various properties of laser light is critical to much of the technology that we use today, from commercial virtual reality (VR) headsets to microscopic imaging for biomedical research. Many of today’s laser systems rely on separate, rotating components to control the wavelength, shape and power of a laser beam, making these devices bulky and difficult to maintain.

Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences have developed a single metasurface that can effectively tune the different properties of laser light, including wavelength, without the need of additional optical components. The metasurface can split light into multiple beams and control their shape and intensity in an independent, precise and power-efficient way.

The research opens the door for lightweight and efficient optical systems for a range of applications, from quantum sensing to VR/AR headsets.

University of Colorado Boulder researchers have discovered that minuscule, self-propelled particles called “nanoswimmers” can escape from mazes as much as 20 times faster than other passive particles, paving the way for their use in everything from industrial clean-ups to medication delivery.

The findings, published this week in the Proceedings of the National Academy of Sciences, describe how these tiny synthetic nanorobots are incredibly effective at escaping cavities within maze-like environments. These nanoswimmers could one day be used to remediate contaminated soil, improve water filtration or even deliver drugs to targeted areas of the body, like within dense tissues.

“This is the discovery of an entirely new phenomenon that points to a broad potential range of applications,” said Daniel Schwartz, senior author of the paper and Glenn L. Murphy Endowed Professor of chemical and biological engineering.

A new WHO reports lays out ethical principles for AI in medicine, but applying them won’t be easy.