A fast-onset, in vivo CRISPR screening platform that facilitates functional genomics with single-cell resolution in embryonic and adult animal brains as well as in peripheral nervous systems is presented.
Artificial intelligence holds huge promise in health care. But it also faces massive barriers.
By analyzing co-evolution of mitochondrial and nuclear genomes across insect species, the authors uncover the evolutionary covariation of a group of non-mitochondrially targeted nuclear genes with mitochondrial genes, including the uncharacterized gene CG11837, which regulates insect lifespan.
University of Queensland researchers have unlocked crucial molecular secrets of ageing in cells, potentially paving the way to improve quality of life as people age.
The study decoded the process by which genes regulate how people mature as they grow and age, and was led by Dr Christian Nefzger from UQ’s Institute for Molecular Bioscience with key contributions from Dr Ralph Patrick and Dr Marina Naval-Sanchez.
Dr Nefzger said that until now the process of how genes change activity from birth to adulthood and into old age was largely unknown.
A study led by Nagoya University Graduate School of Medicine in Japan has revealed a link between gut microbiota and Parkinson’s disease (PD). The researchers found a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7. They also identified a relationship between the lack of these genes and low levels of agents that help maintain the integrity of the intestinal barrier. This barrier prevents toxins from entering the bloodstream, which causes the inflammation seen in PD. Their findings, published in npj Parkinson’s Disease, suggest that treatment with B vitamins to address these deficiencies can be used to treat PD.
PD is characterized by a variety of physical symptoms that hinder daily activities and mobility, such as shaking, slow movement, stiffness, and balance problems. While the frequency of PD may vary between different populations, it is estimated to affect approximately 1–2% of individuals aged 55 years or older.
Various physiological processes are heavily influenced by the microorganisms found in the gut, which are collectively known as gut microbiota. In ideal conditions, gut microbiota produce SCFAs and polyamines, which maintain the intestinal barrier that prevents toxins entering the bloodstream. Toxins in the blood can be carried to the brain where they cause inflammation and affect neurotransmission processes that are critical for maintaining mental health.
Superconductors are materials capable of conducting electricity without any resistance when they are cooled below a specific temperature known as the critical temperature. These materials are used in various applications such as power grids, maglev trains, and medical imaging equipment. High-temperature superconductors, which operate at higher critical temperatures than conventional superconductors, hold great promise for enhancing these technologies. Nonetheless, the underlying mechanisms of their superconductivity are not yet fully understood.
Copper oxides or cuprates, a class of high-temperature superconductors, exhibit superconductivity when electrons and holes (vacant spaces left behind by electrons) are introduced into their crystal structure through a process called doping. Interestingly, in the low-doped state, with less-than-optimal electrons required for superconductivity, a pseudogap –a partial gap in the electronic structure– opens. This pseudogap is considered a potential factor in the origin of superconductivity in these materials.
Helping to defend those tissues are innate lymphoid cells, or ILCs, which when faced with a threat, stimulate proteins called cytokines that further activate the immune system and control the intestinal microbiome.
These cells naturally diminish with aging or can be depleted by certain medical conditions.
ILCs are made inside bone marrow and circulate in the blood. But how are they activated to mobilize and travel to their target sites to replenish the depleted pool of tissue ILCs?
LA JOLLA (March 4, 2024)—Charles Darwin described evolution as “descent with modification.” Genetic information in the form of DNA sequences is copied and passed down from one generation to the next. But this process must also be somewhat flexible, allowing slight variations of genes to arise over time and introduce new traits into the population.
But how did all of this begin? In the origins of life, long before cells and proteins and DNA, could a similar sort of evolution have taken place on a simpler scale? Scientists in the 1960s, including Salk Fellow Leslie Orgel, proposed that life began with the “RNA World,” a hypothetical era in which small, stringy RNA molecules ruled the early Earth and established the dynamics of Darwinian evolution.
New research at the Salk Institute now provides fresh insights on the origins of life, presenting compelling evidence supporting the RNA World hypothesis. The study, published in Proceedings of the National Academy of Sciences (PNAS) on March 4, 2024, unveils an RNA enzyme that can make accurate copies of other functional RNA strands, while also allowing new variants of the molecule to emerge over time. These remarkable capabilities suggest the earliest forms of evolution may have occurred on a molecular scale in RNA.
Over the last year, he has also ramped up work on what will happen if he gets there.
Mr. Musk, 53, has directed SpaceX employees to drill into the design and details of a Martian city, according to five people with knowledge of the efforts and documents viewed by The New York Times. One team is drawing up plans for small dome habitats, including the materials that could be used to build them. Another is working on spacesuits to combat Mars’s hostile environment, while a medical team is researching whether humans can have children there. Mr. Musk has volunteered his sperm to help seed a colony, two people familiar with his comments said.
