Selenoproteins are crucial for several biological functions, including the breakdown of harmful substances, immune system support, and regulating metabolic processes. However, in specific contexts, these proteins can be misused and shield cancer cells from death. One such protein, glutathione peroxidase 4 (GPX4), is vital in supporting cellular protection and cancer cell survival.
“This protective property of GPX4 creates a significant challenge for standard cancer therapies, as its activity has been shown to promote survival of drug-tolerant states,” says Professor Pedro Friedmann Angeli, chair of Translational Cell Biology at the University of Würzburg (JMU), Germany.
“But if we can inhibit GPX4 production, we may be able to target and destroy cancer cells. This is particularly promising for treating neuroblastoma, which primarily affects children.”
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