Gold nanoparticles have been the subject of intense research for several decades due to their interesting applications in fields such as catalysis and medicine. “Surface ligands” are organic molecules typically present on the surface of gold nanoparticles. During synthesis, these surface ligands play an important role in controlling the size and shape of the nanoparticles.
For several decades, the CIC biomaGUNE team led by Ikerbasque Research Professor Luis Liz-Marzán has studied in detail the growth mechanisms and properties of these nanoparticles. Despite numerous advances that have recognized the importance of surface ligands, many questions remain about their exact behavior during and after growth. Direct observation of surface ligands and their interface with gold nanoparticles has therefore been a long-standing goal for many scientists in this field.
Transmission Electron Microscopy (TEM) is the technique most widely used to investigate nanoparticles. However, the study of surface ligands by means of TEM presents significant challenges; the reason is that the ligands are sensitive to the electron beam, their contrast is limited and their structure in vacuum differs from their native state in solution.
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