A team from University Hospitals and Case Western Reserve University has identified a small-molecule drug that effectively reduces cholesterol by 70% in animal models.
PCSK9 inhibitors are the second most common type of medication used to manage cholesterol levels, following statins. These drugs are highly effective at reducing excess cholesterol in the blood, but unlike statins, which can be taken orally, PCSK9 inhibitors must be injected. This can be a barrier to their use for some people.
A small-molecule drug that can be taken orally has been developed by researchers at University Hospitals and Case Western Reserve University School of Medicine. The drug has been shown to significantly reduce PCSK9 levels and lower cholesterol by 70% in animal models. These findings, published in the journal Cell Reports.
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