“This concept that cells ‘fight back’ against modified RNA is of practical importance, as it suggests how one might improve the effectiveness of RNA therapy.”
Researchers from the Smidt Heart Institute have unveiled a novel concept — they harnessed modified messenger RNA (mRNA) technology used in creating the Pfizer and Moderna Covid-19 vaccines, which can be a significant step in the evolution and creation of biological pacemakers.
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The investigators identified how biological pacemaker cells could “fight back” against therapies to biologically correct abnormal heartbeat rates. They’ve also found a new way to “boost the effectiveness” of RNA therapies by controlling the “fighting back” activity, they said in a release.
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