Knowing which proteins are key to protection from disease, and the deficiencies in expression or activity that are hallmarks of disease, can inform individualized medicine and the development of new therapies.
Twenty years after the release of the human genome, the genetic “blueprint” of human life, an international research team, including the University of British Columbia’s Chris Overall, has now mapped the first draft sequence of the human proteome.
Their work was published Oct. 16 in Nature Communications and announced today by the Human Proteome Organization (HUPO).
“Today marks a significant milestone in our overall understanding of human life,” says Overall, a professor in the faculty of dentistry and a member of the Centre for Blood Research at UBC. “Whereas the human genome provides a complete ‘blueprint’ of human genes, the human proteome identifies the individual building blocks of life encoded by this blueprint: proteins. ” Proteins interact to shape everything from life-threatening diseases to cellular structure in our bodies.”
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