The old saying “use it or lose it” very much applies to reducing the impact that aging has on the mind and body. Of all the things we can do right now to help stay healthy as we grow older, exercise is probably the most useful.
Supplements have questionable results in humans, and none can really be described as geroprotective due to the lack of data. However, lifestyle and diet are very important in how we age, and caloric restriction has shown some interesting benefits in multiple species, including humans.
However, of all these things, exercise is probably the most important, and staying active can greatly influence our trajectory towards frailty in old age. Many people do not get the exercise they need as they age and, as a result, this can influence how well they age. Certainly, some level of age-related frailty may be a case of neglect and not exercising enough[1].
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