The location of the solar system’s outer boundary is a point of contention among astronomers. There are three possible candidates, which “all have merit.” But which one is best?
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Apr 2, 2024
MiR-205 knockout surprises with enhanced mammary development and cancer insights
Posted by Shubham Ghosh Roy in category: biotech/medical
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New research unveils the paradoxical role of miR-205 in mammary gland development and its potential impact on breast cancer, highlighting the miRNA’s complex involvement in stem cell regulation and tumor suppression.
Apr 2, 2024
Intrathecal Gene Therapy Shows Promise in Giant Axonal Neuropathy
Posted by Shubham Ghosh Roy in categories: biotech/medical, health
MONDAY, March 25, 2024 (HealthDay News) — Intrathecal gene transfer with scAAV9/JeT-GAN may result in some benefit for children with giant axonal neuropathy, according to a study published in the March 21 issue of the New England Journal of Medicine.
Diana X. Bharucha-Goebel, M.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues conducted an intrathecal dose-escalation study of scAAV9/JeT-GAN in children with giant axonal neuropathy. Fourteen participants received one of four intrathecal doses of scAAV9/JeT-GAN: 3.5 × 1013 total vector genomes (vg); 1.2 × 1014 vg; 1.8 × 1014 vg; and 3.5 × 1014 vg (in two, four, five, and three participants, respectively).
The researchers found that during a median observation period of 68.7 months, one of the 48 serious adverse events was possibly related to treatment and 129 of 682 adverse events were possibly related to treatment. In the total cohort, the mean pretreatment slope was −7.17 percentage points per year. One year posttreatment, posterior mean changes in slope were −0.54, 3.23, 5.32, and 3.43 percentage points with the 3.5 × 1013 vg, 1.2 × 1014 vg, 1.8 × 1014 vg, and 3.5 × 1014 vg doses, respectively. For slowing the slope, the corresponding posterior probabilities were 44, 92, 99 (above the efficacy threshold), and 90 percent, respectively. Sensory-nerve action potential amplitudes increased, stopped declining, or became recordable after being absent in six participants between six and 24 months after gene transfer, but remained absent in eight participants.
Apr 2, 2024
Immunogenicity of the LC16m8 Vaccine Against Mpox
Posted by Shubham Ghosh Roy in category: biotech/medical
Immunization with a vaccinia virus–based vaccine generated robust anti-mpox neutralizing antibody responses in healthy adults.
Apr 2, 2024
Scientists make ‘major finding’ with nanodevices that can seemingly produce energy out of thin air: ‘Contradicting prior understanding’
Posted by Shubham Ghosh Roy in categories: energy, nanotechnology
Two scientists at the Swiss Laboratory of Nanoscience for Energy Technologies in the School of Engineering may have hit upon a way to simultaneously produce clean water and clean electricity, all with zero pollution.
Giulia Tagliabue, the head of the laboratory, and Tarique Anwar, a PhD student, focused their research on hydrovoltaic effects, which can harness the power of evaporation to provide a continuous flow of energy in order to harvest electricity using specialized nanodevices.
Apr 2, 2024
Scientists Inject Patient With Slurry to Make Them Grow a New Liver
Posted by Kelvin Dafiaghor in category: biotech/medical
The experimental cell therapy attempts to grow a second liver on lymph nodes using cells extracted from a donated organ.
Apr 2, 2024
John_Johnston_The_Allure_of_Machinic_Life_(BookZZ.org).pdf
Posted by Dan Breeden in category: robotics/AI
The allure of machinic life cybernetics artificial life and thd new AI.
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Apr 2, 2024
The virtual as the Digital By David Chalmers
Posted by Dan Breeden in category: futurism
The current state of artificial intelligence generative language models is more creative in every devergent thinking test of humans.
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