Lifeboat Foundation

Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies.

Memory CD8⁺ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8⁺ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. Intradermal, but not intraperitoneal vaccination, generated memory precursors expressing skin-homing molecules in circulation and Trm cells in skin. Interestingly, vaccination-induced Trm cell responses strongly suppressed the growth of B16F10 melanoma, independently of circulating memory CD8⁺ T cells, and were able to infiltrate tumors. This work highlights the therapeutic potential of vaccination-induced Trm cell responses to achieve potent protection against skin malignancies.

KEYWORDS: Cancer vaccines, DNA vaccines, intradermal vaccination, melanoma, models of anticancer vaccination, protein vaccines, tissue resident memory CD8⁺ T cells.

Continue reading “Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma” »

Hacker attacks on everything from social media accounts to government files could be largely prevented by the advent of quantum communication, which would use particles of light called “photons” to secure information rather than a crackable code.

Using light to send information is a game of probability: Transmitting one bit of information can take multiple attempts. The more photons a light source can generate per second, the faster the rate of successful information transmission.

“A source might generate a lot of photons per second, but only a few of them may actually be used to transmit information, which strongly limits the speed of quantum communication,” Bogdanov said.

Continue reading “Toward unhackable communication: Single particles of light could bring the ‘quantum internet’” »

In a new #Stanford study explaining the cellular mechanisms behind cognitive impairment from chemotherapy, scientists have demonstrated that a widely used chemotherapy drug, #methotrexate, causes a complex set of problems in three major cell types within the brain’s white matter. The study also identifies a potential remedy.

In a new study explaining the cellular mechanisms behind cognitive impairment from chemotherapy, scientists have demonstrated that a widely used chemotherapy drug, methotrexate, causes a complex set of problems in three major cell types within the brain’s white matter. The study also identifies a potential remedy.

Over seven decades ago in 1941, Isaac Asimov wrote a short story, “Reason” (PDF), in which energy captured from the sun was transmitted via microwave beams to nearby planets from a space station. Flash forward to today, scientists are looking to make that very science fiction dream a reality for Earth.

There has been tremendous research on space-based solar power (SBSP) or space solar power (SSP) since the mid 20th century. Here is a great timeline of the various international studies and projects related to SBSP.

Continue reading “Why the Future of Solar Power Is from Space” »

Messenger RNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far has been finding safe and efficient ways to deliver mRNA molecules to the target cells.

Patients with lung disease could find relief by breathing in messenger RNA molecules.

Researchers from Binghamton University’s Mechanical Engineering Department have developed a way to make cell phones and power lines more durable.

Assistant Professor Sherry Towfighian and graduate student Mark Pallay created a new type of microelectromechanical system – more commonly known as a MEMS switch – that uses electrostatic levitation to provide a more robust system.

“All cell phones use MEMS switches for wireless communication, but traditionally there are just two electrodes,” said Towfighian. “Those switches open and close numerous times during just one hour, but their current lifespan is limited by the two-electrode system.”

Continue reading “Binghamton University researchers design a more durable MEMS switch” »

Researchers at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL) has developed and tested a new #Interferometer

January 3, 2019 — By analyzing a pattern formed by the intersection of two beams of light, researchers can capture elusive details regarding the behavior of mysterious phenomena such as gravitational waves. Creating and precisely measuring these interference patterns would not be possible without instruments called interferometers.

For over three decades, scientists have attempted to improve the sensitivity of interferometers to better detect how the number of photons—particles that make up visible light and other forms of electromagnetic energy—leads to changes in light phases. Attempts to achieve this goal are often hampered by optical loss and noise, both of which can decrease the accuracy of interferometer measurements.

Continue reading “Novel fiber-optic device lays foundation for quantum-enhanced measurements” »

This is a collection of data science, machine learning, analytics, and AI predictions for next year from a number of top industry organizations. See what the insiders feel is on the horizon for 2019!

Data Science Salon Austin, Feb 21–22 — Register Now

It will be a critical flight for SpaceX and NASA.

But SpaceX is hard at work to prevent any disaster from happening.