Lifeboat Foundation

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes to make them better able to travel via blood vessels to reach the site of infection. Their work appears on January 15 in the journal Immunity.

“One good thing about fever is that it can promote lymphocyte trafficking to the site of infection, so you will have more immune cells in the infected region that will get rid of the pathogen,” says Shanghai Institute of Biochemistry and Cell Biology (SIBCB) Professor and senior author JianFeng Chen.

To get to an infection, white blood cells need to adhere to the blood vessel and then transmigrate into the infected tissue or lymph node. During this step, molecules known as integrins are expressed on the surface of lymphocytes. Integrins are cell adhesion molecules that control lymphocyte trafficking during inflammation.

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Marijuana compound reduces mental decline in HIV patients.

Spinal cord injuries (SCIs) affect approximately 300,000 Americans, with about 18,000 new cases occurring per year. One of these patients, Jake Javier, who we have written about many times over the past several years, received ten million stem cells as part of a CIRM-funded clinical trial and a video about his first year at Cal Poly depicts how these injuries can impact someone’s life.

Currently, there is nothing that completely reverses SCI damage and most treatment is aimed at rehabilitation and empowering patients to lead as normal a life as possible under the circumstances. Improved treatment options are necessary both to improve patients’ overall quality of life, and to reduce associated healthcare costs.

Scientists at UC San Diego’s School of Medicine and Institute of Engineering in Medicine have made critical progress in providing SCI patients with hope towards a more comprehensive and longer lasting treatment option.

Continue reading “Using 3D printer to develop treatment for spinal cord injury” »

Can the length of strands of DNA in patients with heart disease predict their life expectancy? Researchers from the Intermountain Heart Institute at Intermountain Medical Center in Salt Lake City, who studied the DNA of more than 3,500 patients with heart disease, say yes it can.

Scientists working to develop more effective treatments for diabetes are turning to stem cells. Such cells can be transformed into cells that produce insulin, the hormone that controls blood sugar.

But there’s a major challenge: the amount of insulin produced by theses cells is difficult to control.

Now, by tweaking the recipe for coaxing human stem cells into insulin-secreting beta cells, a team of researchers at Washington University School of Medicine in St. Louis has shown that the resulting cells are more responsive to fluctuating glucose levels in the blood.

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An experimental drug may help people with type 2 diabetes curb their blood sugar without causing it to drop to dangerously low levels.

Researchers found that the compound—dubbed TTP399 for now—improved patients’ blood sugar control when it was added to the standard medication metformin for six months.

And it did so without causing hypoglycemia—blood sugar drops that, if severe, can lead to convulsions or loss of consciousness.

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A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells—which can give rise to every cell type in the body and which can be grown indefinitely in the lab—into becoming mature T cells capable of killing tumor cells.

The technique uses structures called artificial thymic organoids, which work by mimicking the environment of the thymus, the organ in which T cells develop from blood stem cells.

T cells are cells of the immune system that fight infections, but also have the potential to eliminate cancer cells. The ability to create them from self-renewing pluripotent stem cells using the UCLA technique could lead to new approaches to cancer immunotherapy and could spur further research on T cell therapies for viral infections such as HIV, and autoimmune diseases. Among the technique’s most promising aspects is that it can be combined with gene editing approaches to create a virtually unlimited supply of T cells able to be used across large numbers of patients, without the need to use a patient’s own T cells.

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For the first time, researchers have documented the long-predicted occurrence of ‘walls bound by strings’ in superfluid helium-3. The existence of such an object, originally foreseen by cosmology theorists, may help explaining how the universe cooled down after the Big Bang. With the newfound ability to recreate these structures in the lab, earth-based scientists finally have a way to study some of the possible scenarios that might have taken place in the early universe more closely.

Tobacco and alcohol use, both genetically inheritable behaviors, influence risk for many complex diseases and disorders and are leading causes of mortality.

The University of Minnesota was part of a research collaboration that conducted the first study, recently published in Nature Genetics, to identify hundreds of genomic locations associated with addictive behaviors. Researchers found more than 500 genetic variants that affect the use of and addiction to tobacco and alcohol. Until now, only a few of such variants had been identified.

Researchers studied 1.2 million people and looked five characteristics including the age when a participant began smoking; the number of cigarettes per day the participant smoked; whether the participant has ever been a regular smoker; whether the participant ever quit smoking; and the number of alcoholic drinks the participant had per week.

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