Lifeboat Foundation

San Diego-based biotechnology company Samumed has recently announced that it will be moving to phase 3 clinical trials of its drug lorecivivint (SM04690) for the treatment of knee osteoarthritis.

What is osteoarthritis?

Osteoarthritis is the most common form of arthritis in the knee and a leading cause of adult disability, particularly among older people. This degenerative, “wear-and-tear” arthritis is characterized by the destruction of the articular cartilage and structural changes to the bone, which leads to pain, inflammation, and loss of joint function and mobility. It occurs most often in people who are at least 50 years old, but it may occur in younger people as well.

Continue reading “Samumed Begins Phase 3 Trial for Knee Osteoarthritis” »

The latest SpaceX Dragon cargo mission to the International Space Station (ISS) included an experiment that could help to combat the ravages of time here on Earth. The European experiment will test how ceramic nanoparticles interact with cells to act as an anti-aging supplement that not only holds promise for alleviating the effects of growing old, but also for combatting chronic illness and space-related stresses for astronauts on prolonged space missions.

Coffee… mostly, I drink coffee.

A kindergartener once asked me, “why don’t you wear science clothes?” I gathered that she meant a lab coat. Then there is the utter surprise my neighbors show when I tell them—yes—I am on my way to work wearing sandals, shorts and a t-shirt. Take a moment and do a google image search of “scientist”. You have to scroll through several pages before you see a person not wearing a lab coat. So if I don’t wear a lab coat while staring into a beaker as if the colorful liquid inside contained a part of my soul, what do I do all day?

Continue reading “Just what does a postdoctoral theoretical physicist do all day?” »

Even in this “age of the genome,” much about genes remains shrouded in mystery. This is especially true for “cryptic mutations”—mutated genes that are hidden, and have unexpected effects on traits that are only revealed when combined with other mutations. Learning from one infamous cryptic mutation in particular, researchers from CSHL share important lessons for breeding or gene editing in crops.

This story starts with the Campbell Soup Company and a field of tomatoes in the mid 20th century. One particular tomato plant had an unexpected beneficial trait: the fruits separated from the vine right where the green cap and stem touch the rest of the fruit. It turned out that this spontaneous natural mutant was ideal for large-scale production.

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In trying to answer such questions, scientists bump up against the limits of the laws of physics. Existing theories can account for the evolution of the universe from its earliest moments — from a fraction of a second after the Big Bang — but the question of what came before has been among the most vexing in all of science.

“It’s my life’s work to try to answer that question,” University of Toronto physicist Renée Hložek says.

This image represents the evolution of the universe, starting with the Big Bang. The red arrow marks the flow of time.

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In the end, it wasn’t meant to be. Microsoft had pulled out all the stops for its Build 2019 developer conference keynote on Monday morning. The company had partnered with Epic Games and Industrial Light & Magic chief creative officer John Knoll for a hugely ambitious demo of its Hololens 2 headset that aimed to recreate the Apollo 11 moon landing, 50 years after the fact, in mixed reality.

All had worked out well during multiple rehearsals over the last few days. But when Knoll and science journalist and “Man on the Moon” author Andrew Chaikin were set to go on stage on Monday, the demo just didn’t run. Microsoft stalled by extending its pre-show ImagineCup competition until the show’s moderator couldn’t think of any more questions to ask. Then Knoll and Chaikin went on stage, giving it one more go — and the mixed-reality overlays simply refused to appear.

Continue reading “How Epic & ILM’s John Knoll Tried to Recreate the Moon Landing for Microsoft’s Build 2019 Keynote” »

Internet theorists and companies once declared themselves free of nations and governance, but that’s all over now.

The idea is to place two or three satellites in circular orbit around the Earth to observe black holes. The concept goes by the name Event Horizon Imager (EHI). In their new study, the scientists present simulations of what images of the black hole Sagittarius A would look if they were taken by satellites like these.

More than five times as sharp

“There are lots of advantages to using satellites instead of permanent radio telescopes on Earth, as with the Event Horizon Telescope (EHT),” says Freek Roelofs, a PhD candidate at Radboud University and the lead author of the article. “In space, you can make observations at higher radio frequencies, because the frequencies from Earth are filtered out by the atmosphere. The distances between the telescopes in space are also larger. This allows us to take a big step forward. We would be able to take images with a resolution more than five times what is possible with the EHT.”

Continue reading “Telescopes in space for even sharper images of black holes” »