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Summary: Researchers successfully connected lab-grown brain tissues, mimicking the complex networks found in the human brain. This novel method involves linking “neural organoids” with axonal bundles, enabling the study of interregional brain connections and their role in human cognitive functions.

The connected organoids exhibited more sophisticated activity patterns, demonstrating both the generation and synchronization of electrical activity akin to natural brain functions. This breakthrough not only enhances our understanding of brain network development and plasticity but also opens new avenues for researching neurological and psychiatric disorders, offering hope for more effective treatments.

In February 2023, Frontiers in Science published an article titled “Organoid Intelligence (OI): The New Frontier in Biocomputing and Intelligence-in-a-Dish.” Since its publication, this research has sparked significant scientific interest and gained coverage in Forbes, Financial Times, Wall Street Journal, BBC, CNN and many others.

So, what is organoid intelligence and why has this article gathered such attention?

Continue reading “Brain in a dish — the potential of organoid intelligence and biological computing” »

Domain walls, long a divisive topic in physics, may be ideal explanations for some bizarre cosmic quirks.

By Anil Ananthaswamy

“As long as they live for long enough, they will always become large cosmological beasts,” says Ricardo Ferreira, a cosmologist at the University of Coimbra in Portugal. He’s not talking about actual beasts but rather about hypothetical humongous sheets of spacetime that could divide one region of the universe from another. Such so-called domain walls are the natural outcome of theories that try to solve some of the deepest mysteries in physics, such as the origins of gravity. As Ferreira says, however, had they formed after the big bang, by today they’d be the dominant source of energy in our universe, and there’s no evidence that’s the case. So any theory invoking their existence has been considered suspect—until now, perhaps.

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In an effort to make them useless to poachers, researchers are implanting radioactive isotopes into the horns of rhinos in South Africa.

The unusual material would “render the horn useless… essentially poisonous for human consumption,” James Larkin, professor and dean of science at the University of the Witwatersrand in Johannesburg, told Agence France-Presse.

The isotopes would also be “strong enough to set off detectors that are installed globally,” Larkin added, referring to hardware that was originally installed to “prevent nuclear terrorism.”

Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles — structures that transport waste or food within cells.

In a recent ACS Nano paper (“The Secret Ballet Inside Multivesicular Bodies”), Luis Mayorga and Diego Masone shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.

A representation of multilayer lipid vesicles inspired by “Color Study: Squares with Concentric Circles,” by the artist Wassily Kandinsky. (Image: ACS Nano 2024, DOI: 10.1021/acsnano.4c01590)

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“Surfaces were invented by the devil” — this quote is attributed to the theoretical physicist Wolfgang Pauli, who taught at ETH Zurich for many years and in 1945 received the Nobel Prize in physics for his contributions to quantum mechanics. Researchers do, indeed, struggle with surfaces. On the one hand they are extremely important both in animate and inanimate nature, but on the other hand it can be devilishly difficult to study them with conventional methods.

An interdisciplinary team of materials scientists and electrical engineers led by Lukas Novotny, Professor of Photonics at ETH Zurich, together with colleagues at Humboldt-Universität zu Berlin has now developed a method that will make the characterization of surfaces considerably easier in the future.

They recently published the results of their research, which is based on an extremely thin gold membrane, in the scientific journal Nature Communications (“Bulk-suppressed and surface-sensitive Raman scattering by transferable plasmonic membranes with irregular slot-shaped nanopores”).

About 170 billion cells are in the brain, and as they go about their regular tasks, they produce waste — a lot of it.

The brain appears to rely on synchronized waves to wash out waste products, including toxins associated with Alzheimer’s disease.