Lifeboat Foundation

DOI: Abstract We are living in a historical period in respect to the deterioration in public health, as we experience the rise of the catastrophic obesity epidemic and mental health crisis in recent decades, despite the great efforts from the scientific and medical community to seek health solutions and to try to find cures to the enormous human suffering and economic costs resulting by this collapse in public health. This trend has reached such a critical level that it jeopardizes society when over 40% of the population is obese in the United States, suffering grave medical health conditions, even as the expenditure on public health is rising exponentially to over 20% of gross domestic product. This should point to a monumental failure in our fundamental understanding of basic human biology and health. This article suggests that our current Western reductionist scientific paradigm in both biology and medicine has proved impotent and failed us completely. Therefore, the current cultural health crises require a more holistic approach to human biology and health in terms of chronobiological trends. The emerging neuroscience of brain energy metabolism will be considered as a holistic model for understanding how solar cycles affect our civilization and drive our sex and growth hormones and neurotransmitters that shape both our physical and mental health.

Children with hereditary deafness regained their hearing thanks to a type of gene therapy, a new study published on Wednesday found.

In a clinical trial, co-led by investigators from Mass Eye and Ear, a specialty hospital in Boston, six children who had a form of genetic deafness called DFNB9 were examined.

This deafness is caused by mutations of the OTOF gene. This mutation fails to produce a protein known as otoferlin, which is necessary for the transmission of sound signals from the ear to the brain, according to the researchers.

A recent study from Stanford’s Wu Tsai Neurosciences Institute has shed light on the interplay between two key brain chemicals, dopamine and serotonin, revealing their opposing roles in shaping our decisions and learning processes. Published in Nature, the research demonstrates for the first time that dopamine and serotonin operate as a “gas and brake” system, jointly influencing how we learn from rewards. The findings have broad implications, from understanding everyday decision-making to developing treatments for neurological and psychiatric conditions such as addiction, depression, and Parkinson’s disease.

Dopamine and serotonin are crucial to many aspects of human behavior, including reward processing and decision-making. Both neurotransmitters are also implicated in a variety of mental health disorders. While previous research has established their individual roles—dopamine is linked to reward prediction and seeking, while serotonin promotes long-term thinking and patience—the precise nature of their interaction has remained unclear.

Two competing theories have sought to explain their dynamic: the “synergy hypothesis,” which posits that dopamine focuses on immediate rewards and serotonin on long-term benefits, and the “opponency hypothesis,” suggesting the two act in opposition, with dopamine encouraging impulsive action and serotonin promoting restraint. The Stanford researchers aimed to directly test these theories using advanced experimental methods.

Botto, described as a “decentralized autonomous artist,” has made more than $5 million since its inception in 2021.

An exploration of whether mass extinction events lead to a higher likelihood of intelligence and complexity of life on earth and exoplanets.

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EzSingleCell is an interactive and user-friendly application for the analysis of single-cell and spatial omics data, without the need for programming expertise. Here, authors integrated top-performing publicly available methods to enable comprehensive data analysis and interactive visualisation.

MIT physicists and colleagues have for the first time measured the geometry, or shape, of electrons in solids at the quantum level. Scientists have long known how to measure the energies and velocities of electrons in crystalline materials, but until now, those systems’ quantum geometry could only be inferred theoretically, or sometimes not at all.

The work, reported in the November 25 issue of Nature Physics, “opens new avenues for understanding and manipulating the quantum properties of materials,” says Riccardo Comin, MIT’s Class of 1947 Career Development Associate Professor of Physics and leader of the work.

“We’ve essentially developed a blueprint for obtaining some completely new information that couldn’t be obtained before,” says Comin, who is also affiliated with MIT’s Materials Research Laboratory and the Research Laboratory of Electronics.

String theory proposes that all particles and forces are made of tiny, vibrating strings, which form the fundamental building blocks of the universe. This framework offers a potential solution to the long-standing paradoxes surrounding black holes, such as their singularities—infinitely tiny points where the laws of physics break down—and the Hawking radiation paradox, which questions the fate of information falling into black holes.

Fuzzballs replace the singularity with an ultra-compressed sphere of strings, likened to a neutron star’s structure but composed of subatomic strings instead of particles. While the theory remains incomplete, its implications are significant, offering an alternative explanation for phenomena previously attributed to black holes.

To differentiate between black holes and fuzzballs, researchers are turning to gravitational waves—ripples in spacetime caused by cosmic collisions. When black holes merge, they emit specific gravitational wave signatures that have so far aligned perfectly with Einstein’s general relativity. However, fuzzballs might produce subtle deviations from these patterns, providing a way to confirm their existence.

The tech company also plans to make an Act II of the show, which will feature a second round of Shakespearean actors in new digital portraits next year.

“This collection is the culmination of profound collaborations with some of the most iconic actors of our time,” says Sattari-Hicks in a statement. “This is only the beginning, with many renowned home-grown and international talents already in line for future collections.”

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