Lifeboat Foundation

The BACE1 enzyme has a rate-limiting role in the amyloidogenic pathway (see Glossary) and has been extensively studied for its neuronal functions[1]. Since 2000, intensive efforts have focused on developing small-molecule BACE1 inhibitors to reduce amyloid β (Aβ) production in Alzheimer’s disease (AD) brains. However, human clinical trials involving most BACE1 inhibitors were stopped at Phase 2/3 due to limited therapeutic benefits[2]. BACE1 inhibitors act by reducing Aβ-related pathologies in AD brains, that is, they are used to treat the symptoms rather than the underlying disease.

While grand spaceflight plans of some nations have ended up many years behind schedule, China completed the assembly in orbit of its Tiangong space station in late October, only 22 months later than planned. And on Nov. 29, the Shenzhou 15 mission blasted off from China’s Jiuquan Satellite Launch Center deep in the Gobi Desert and took three astronauts to the space station to begin permanent occupancy of the outpost.

These human spaceflight achievements, combined with recent space probes to the moon and Mars, add to the evidence that China is running a steady space marathon rather than competing in a head-to-head space race with the United States. That China’s space program is making good time toward its long-term goals was reinforced during a rare visit for foreign media to the country’s heavily guarded desert rocket base for the Nov. 29 launch — including lengthy interviews with senior Chinese space officials by in for The New York Times.

It was supposed to be just another spacewalk, a simple routine inspection.

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Let’s talk about AI Art, Lensa, ChatGPT, and why it’s all deeper than you think.

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Continue reading “The Truth About AI Getting ‘Creative’” »

And how we can use them. “The Landscape of AI Tools” is published by HungryMinded in Seeds For The Future.

When the makers of electronic implants abandon their projects, people who rely on the devices have everything to lose.

Clean energy will reduce dependency on Russia and Arab countries for oil and gas.

What if the weight could instead be distributed between multiple support poles? That’s the design Eolink has in mind; its floating turbine swaps out the single large pole for four thinner ones angled towards each other in a pyramid shape. This not only distributes the weight of the turbine’s pieces, it allows the whole structure to be lighter.

The turbine Eolink plans to build as a proof of concept will have a generating capacity of five megawatts and weigh 1,100 tons. Its base will be a square with each side 171 feet (52 meters) long, and its rotor’s diameter will be 469 feet (143 meters). For reference, that’s about one and a half Big Bens, or four-fifths of the Washington Monument.

Continue reading “This Floating ‘Pyramid’ Wind Turbine Will Produce More Energy at a Lower Cost, Company Says” »

FTX founder Sam Bankman-Fried was arrested in the Bahamas at the behest of US prosecutors on Monday, the day before he was due to testify before Congress about the abrupt failure last month of one of the world’s largest cryptocurrency exchanges.

#FTX #SamBankmanFried #Bahamas.

Continue reading “Former FTX founder Sam Bankman-Fried arrested in Bahamas after US files charges | Latest World News” »

Solar cell technology is a seen as a key pillar in our transition to cleaner forms of energy, but within this field there is all kinds of room for experimentation. Solar cells that are thin and flexible hold unique promise in the area, as they could be applied to all kinds of irregular, curvy or otherwise unsuitable surfaces. Thinner than a human hair, a new lightweight solar cell from MIT scientists continues to push the envelope in this space.

The MIT team behind the technology sought to build on its previous advances in material science, which in 2016 culminated in ultra-thin solar cells light enough to sit atop a soap bubble without breaking it. As is the case with other thin, light and flexible solar cells we’ve looked at over the years, this pointed to all kinds of possibilities, from paper-based electronics to lightweight wearables that harvest energy throughout your day.

Despite the potential, the team still had some problems to solve, with the fabrication technique for the solar cells requiring vacuum chambers and expensive vapor deposition methods. In order to scale the technology up, the scientists have now turned to ink-based printable materials to streamline the process.