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Apr 19, 2022

Dr. Erin Duffy, Ph.D. & Kevin Outterson, ESQ — Combating Antibiotic-Resistant Bacteria (CARB-X)

Posted by in categories: biotech/medical, computing, health, law

Combating Antibiotic-Resistant Bacteria — Dr. Erin Duffy, Ph.D., Chief of Research & Development, and Kevin Outterson, ESQ., Executive Director, CARB-X.


The Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X — https://carb-x.org/) is a global non-profit partnership accelerating antibacterial products to address drug-resistant bacteria, a leading cause of death around the world. 1.27 million deaths worldwide were attributed to resistant bacterial infections in 2019.

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Apr 19, 2022

Dr. Andrew Adams, PhD — Lilly Institute for Genetic Medicine — Targeting Root Causes Of Diseases

Posted by in categories: biotech/medical, genetics

Targeting Root Causes Of Diseases And Aging — Dr. Andrew Adams, Ph.D., Vice President, Neurodegeneration Research; Co-Director, Lilly Institute for Genetic Medicine, Eli Lilly.


Dr. Andrew Adams, Ph.D. is Vice President of Neurodegeneration Research at Eli Lilly (https://www.lilly.com/) and Co-Director of their new Lilly Institute for Genetic Medicine (https://lilly.mediaroom.com/2022-02-22-Lilly-Announc…ort-Site), a $700 million initiative to establish an institute for researching and developing genetic medicines, specifically acting at the nucleic acid level, to advance an entirely new drug class that target the root cause of diseases, an approach that is fundamentally different than medicines available today.

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Apr 19, 2022

How an accidental discovery made this year could change the world

Posted by in category: energy

A lucky discovery involving lithium-sulfur batteries has a legitimate chance to revolutionize how we power our world.

Apr 19, 2022

Private Ax-1 mission’s ISS departure delayed to Tuesday evening

Posted by in category: space travel

The four Ax-1 astronauts will get to spend about 12 extra hours on the orbiting lab.


The first-ever fully private crewed mission to the International Space Station will get to spend 12 extra hours aboard the orbiting lab.

The four astronauts of Ax-1, a mission organized by Houston company Axiom Space, had been scheduled to depart the station in their SpaceX Dragon capsule at 10:35 a.m. EDT (1435 GMT) on Tuesday (April 19) and splash down off the coast of Florida early Wednesday morning (April 20).

Apr 19, 2022

SpaceX’s Brand-New Dragon Spacecraft “Freedom” Arrives at NASA’s Kennedy Space Center

Posted by in category: space

SpaceXs brand-new Dragon spacecraft – named “Freedom” by the Crew-4 astronauts – arrived at Kennedy Space Center’s Launch Complex 39A on April 16, 2022, after making the journey from SpaceX’s processing facility at nearby Cape Canaveral Space Force Station in Florida. After Dragon is mated to the SpaceX Falcon 9 rocket, the launch vehicle will roll out to the pad and be raised to the vertical launch position.

Liftoff is scheduled for 5:26 a.m. EDT on Saturday, April 23. NASA’s Crew-4 mission is the fourth crew rotation flight on a SpaceX Dragon spacecraft and Falcon 9 rocket. NASA astronauts Kjell Lindgren and Bob Hines will serve as mission commander and pilot, respectively, and NASA astronaut Jessica Watkins and ESA (European Space Agency) astronaut Samantha Cristoforetti, will join as mission specialists.

Apr 19, 2022

SpaceX Crew-4: Launch date, crew, mission goals of

Posted by in category: space travel

If all goes according to plan, Jessica Watkins will become the first African-American woman to make a prolonged ISS stay.

Apr 19, 2022

Quantum experiments add weight to a fringe theory of consciousness

Posted by in categories: neuroscience, quantum physics

Experiments on how anaesthetics alter the behaviour of tiny structures found in brain cells bolster the controversial idea that quantum effects in the brain might explain consciousness.

Apr 19, 2022

How we drained California dry

Posted by in category: futurism

A story of remaking the land and taking the water until there was nothing left.

Apr 19, 2022

Study evaluates deep learning models that decode the functional properties of proteins

Posted by in categories: biotech/medical, genetics, robotics/AI

Deep learning–based language models, such as BERT, T5, XLNet and GPT, are promising for analyzing speech and texts. In recent years, however, they have also been applied in the fields of biomedicine and biotechnology to study genetic codes and proteins.

Apr 19, 2022

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Posted by in categories: biotech/medical, genetics, satellites

Circa 2021


As described above, molecular therapeutics enabling expression of a truncated dystrophin have been far developed. However, an unprecedented opportunity to correct the disease-causing mutation has arisen with the advent of Crispr-Cas9 technology (Fig. 1).

Since the generation of a Cas9-transgenic mouse [28], which allowed for pinpoint gene alterations specifically in organs targeted by AAVs encoding for the corresponding guide RNAs (gRNAs), it became clear that the inevitable course of inherited diseases might be altered by Cas9-mediated correction. Although certain limitations were unmasked early on, such as the preference of non-homologous end-joining (NHEJ) over homology-directed repair (HDR) upon enzymatic cleavage of the double stranded DNA by Cas9, or the packaging capacity of AAVs, muscular dystrophies seemed an ideal target for genome editing. DMD mutations inducing Duchenne muscular dystrophy (DMD) seemed particularly well suited, since internal truncations of the protein may lead to a shortened but stable protein with partial functional restitution and a milder disease progression, as seen in the allelic Becker muscular dystrophy (BMD).

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