Lifeboat Foundation

CRISPR/Cas9, a powerful gene editing technique that has already been used in a human, is thought by many as a “cut and paste” for DNA in living organisms. While in a sense that is what happens, delivering the ribonucleoprotein that does the genetic editing and the RNA that hones in on the target, into the cellular nucleus without being damaged is a challenge. That is why the efficiency of successful edits remains very low. Researchers at University of Massachusetts Amherst have now come up with nanoparticles that protect the protein and RNA as they’re brought to their work site.

The nanoparticles are engineered around their cargo and have shown a 90% success rate of getting the cargo into the nucleus, and a 30% editing efficiency, which is “remarkable” according to the researchers. So far the team has tested their technique on cultured cells, but they’re already working on trying the same in laboratory animals. As part of their research, they developed a novel way of tracking the Cas9 protein inside the cells, something that will certainly help other scientists in this area.

“By finely tuning the interactions between engineered Cas9En protein and nanoparticles, we were able to construct these delivery vectors. The vectors carrying the Cas9 protein and sgRNA come into contact with the cell membrane, fuse, and release the Cas9:sgRNA directly into the cell cytoplasm,” in a statement said Vincent Rotello, lead author of the study in ACS Nano. “Cas9 protein also has a nuclear guiding sequence that ushers the complex into the destination nucleus. The key is to tweak the Cas9 protein,” he adds. “We have delivered this Cas9 protein and sgRNA pair into the cell nucleus without getting it trapped on its way. We have watched the delivery process live in real time using sophisticated microscopy.”

Continue reading “Nanoparticles Deliver CRISPR/Cas9 Genetic Editor Safely Into Cells” »

I do have many friends working on this commercially; however, I prefer the work we’re doing in the Quantum Bio base around brain advancement v. deep mind learning/ intelligence research.

A site dedicated to the sciences, recent scientific discoveries and advances.

Quantum mechanics, the physics that governs nature at the atomic and subatomic scale, contains a host of new physical phenomena to explore quantum states at the nanoscale. Though tricky, there are ways to exploit these inherently fragile and sensitive systems for quantum sensing. One nascent technology in particular makes use of point defects, or single-atom misplacements, in nanoscale materials, such as diamond nanoparticles, to measure electromagnetic fields, temperature, pressure, frequency and other variables with unprecedented precision and accuracy.

Quantum sensing could revolutionize medical diagnostics, enable new drug development, improve the design of electronic devices and more.

For use in quantum sensing, the bulk nanodiamond crystal surrounding the point defect must be highly perfect. Any deviation from perfection, such as additional missing atoms, strain in the crystalline lattice of the diamond, or the presence of other impurities, will adversely affect the quantum behavior of the material. Highly perfect nanodiamonds are also quite expensive and difficult to make.

Members of the Faculty of Physics, the Lomonosov Moscow State University have elaborated a new technique for creation of entangled photon states, exhibiting photon pairs, which get correlated (interrelated) with each other. Scientists have described their research in an article, published in the journal Physical Review Letters.

Physicists from the Lomonosov Moscow State University have studied an entangled photon state, in which the state is determined only for the whole system and not for each separate particle.

Stanislav Straupe, Doctor of Sciences in Physics and Mathematics, a member of the Quantum Electronics Department and Quantum Optical Technologies Laboratory at the Faculty of Physics, the Lomonosov Moscow State University, and one of the article co-authors says the following. He explains: “Entangled states are typical and general. The only problem is in the point that for the majority of particles interaction with the environment destroys the entanglement. And photons hardly ever interact with other particles, thus they are a very convenient object for experiments in this sphere. The largest part of light sources we face in our life is a classical one — for instance, the Sun, stars, incandescent lamps and so on. Coherent laser radiation also belongs to the classical part. To create nonclassical light isn’t an easy thing. You could, for instance, isolate a single atom or an artificial structure like a quantum dot and detect its radiation – this is the way for single photons obtaining.”

Continue reading “A new technique for creation of entangled photon states developed” »

Cybercrime & Cybersecurity 0 20

There is a reason why they’re not in the private sector developing QC. Noticed all represented no one developing and delivering QC commercially. There is a reason why folks like this become nay sayers as it is hard when you’re not able to deliver and not hireable by the private sector to deliver QC. With such a huge demand for QC experts and in security; you have to wonder why these folks have not been employed in a QC Tech company especially when you see tech grabbing every professor they can to develop QC and especially cyber security. Also, I still never saw any bases or details scientifically for their argument why specifically where and how QC will not block hacking just a bunch of professors throwing out words and high level speculations.

SAN FRANCISCO—Cryptographers said at the RSA Conference Tuesday they’re skeptical that advances in quantum computing and artificial intelligence will profoundly transform computer security.

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The findings suggest that there are many more planets out there waiting to be found – which might support alien life.

Meet the world’s first flying car.

Yep; we know and we can even design them to make their own.

You could now 3D print your own tiny walking “bio-bots” powered by living muscle cells and controlled with electrical and light pulses, thanks to a new gennext robot ‘recipe’ developed by scientists.

This can result in exciting possibilities where these “systems could one day demonstrate complex behaviours including self-assembly, self-organisation, self-healing, and adaptation of composition and functionality to best suit their environment,” researchers said.

“The protocol teaches every step of building a bio-bot, from 3D printing the skeleton to tissue engineering the skeletal muscle actuator, including manufacturers and part numbers for every single thing we use in the lab,” said Ritu Raman, a postdoctoral fellow at the University of Illinois at Urbana-Champaign in the US.

Continue reading “You can now build your own 3D printed bio-bots” »