Lifeboat Foundation

DNA, the stuff of life, may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices.

Much like flipping your light switch at home — –only on a scale 1,000 times smaller than a human hair — –an ASU-led team has now developed the first controllable DNA switch to regulate the flow of electricity within a single, atomic-sized molecule. The new study, led by ASU Biodesign Institute researcher Nongjian Tao, was published in the advanced online journal Nature Communications ( DOI: 10.1038/ncomms14471).

“It has been established that charge transport is possible in DNA, but for a useful device, one wants to be able to turn the charge transport on and off. We achieved this goal by chemically modifying DNA,” said Tao, who directs the Biodesign Center for Bioelectronics and Biosensors and is a professor in the Fulton Schools of Engineering.

Continue reading “Switched-on DNA spark nano-electronic applications” »

Contrary to what has long been believed, the role of the sympathetic nervous system in muscle tissue goes far beyond controlling blood flow by contracting or relaxing blood vessels, according to studies conducted at the University of São Paulo (USP) in Brazil.

With support from FAPESP and the collaboration of researchers at Mannheim University and Heidelberg University in Germany, a group of Brazilian researchers led by Isis do Carmo Kettelhut and Luiz Carlos Carvalho Navegantes at the University of São Paulo’s Ribeirão Preto Medical School (FMRP –USP) have demonstrated the importance of sympathetic innervation for the growth and maintenance of muscle mass and also for the control of movement.

Kettelhut is a full professor at FMRP -USP’s Biochemistry & Immunology Department. Navegantes is a professor in the same institution’s Physiology Department.

Continue reading “Study Reveals Essential Role of Sympathetic Nerves in Muscle Health” »

Green: NAc-projecting prefrontal cortex neurons become active during the presentation of a reward-predictive cue, and this activity drives reward-seeking behavior. Purple: PVT-projecting prefrontal cortex neurons inhibited during reward-predictive cue. Credit: The Stuber Lab (UNC School of Medicine)

The prefrontal cortex, a large and recently evolved structure that wraps the front of the brain, has powerful “executive” control over behavior, particularly in humans. The details of how it exerts that control have been elusive, but UNC School of Medicine scientists, publishing today in Nature, have now uncovered some of those details, using sophisticated techniques for recording and controlling the activity of neurons in live mice.

Got OCD; check your genes for a mutation.

A new Northwestern Medicine study found evidence suggesting how neural dysfunction in a certain region of the brain can lead to obsessive and repetitive behaviors much like obsessive-compulsive disorder (OCD).

Both in humans and in mice, there is a circuit in the brain called the corticostriatal connection that regulates habitual and repetitive actions. The study found certain synaptic receptors are important for the development of this brain circuit. If these receptors are eliminated in mice, they exhibit obsessive behavior, such as over-grooming.

Continue reading “OCD-like behavior linked to genetic mutation, study finds” »

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In recent years, we have dramatically changed our view of human genome, from a collection of DNA base pairs that was largely quite stable to one whose very structure can change. We’ve learned that higher-order structural features, such as specific configurations of repeated base pair sequences, can predispose for DNA rearrangements.

One of the most intriguing types of DNA rearrangements is copy-number variants (CNVs), deletions or duplications of parts of the genome. While CNVs range in size from a few hundred base pairs to several mega-bases affecting the copy number of one to dozens of juxtaposed genes, they are not identifiable by conventional light microscopy. It was not until a few years ago that improved technology enabled us to perform high-resolution genome-wide surveys of CNVs in individual genomes. These surveys revealed a large amount of copy number variation (at least 12,000 CNVs overlapping more than 1,000 genes), most of which represent benign polymorphic changes. CNVs are classified as rare (occurring at a frequency of 1 percent in the population) or common; collectively they cover at least 12–13 percent of the genome in the general population.

Very cool.

A research group from Bar-Ilan University, in collaboration with French colleagues at CNRS Grenoble, has developed a unique experiment to detect quantum events in ultra-thin films. This novel research, to be published in the scientific journal Nature Communications, enhances the understanding of basic phenomena that occur in nano-sized systems close to absolute zero temperature.

Transitions, Phases and Critical Points

Continue reading “Scientists create a nano-trampoline to probe quantum behavior” »

Luminescent solar concentrators (LSCs), which are flat panes of mostly transparent material that take sunlight (both diffuse and directed) and concentrate it at the panes’ edges, can be used as “photovoltaic windows,” which, as the name makes clear, collect solar energy while serving as ordinary windows. Now, researchers at the Università degli Studi di Milano-Bicocca and Glass to Power Srl (both of Milano, Italy) and the University of Minnesota (Minneapolis, MN) are lowering the potential cost of such windows by using silicon nanoparticles as the fluorescent absorber/emitter in the LSC windows.

Transhumanism also covered, albeit not in the best light. https://news.yahoo.com/mature-enough-deal-climate-change-194506529.html

Mapping of the human genome has gone from costing billions to merely thousands. As this trend continues we will be able to tailor drugs to individuals.