Lifeboat Foundation

Columbia University scientists recently tested a new optical technique to study how information is transmitted in the brains of mice and made a surprising discovery: When stimulated electrically to release dopamine (a neurotransmitter or chemical released by neurons, or nerve cells, to send signals to other nerve cells), only about 20 percent of synapses — the connections between cells that control brain activity — were active at any given time.

The effect had never been noticed. “Older techniques only revealed what was going on in large groups of synapses,” explained David Sulzer, PhD, professor of neurobiology in Psychiatry, Neurology, and Pharmacology at Columbia University Medical Center (CUMC). “We needed a way to observe the neurotransmitter activity of individual synapses, to help us better understand their intricate behavior.”

Continue reading “The case of the silent synapses: Why are only 20% of synapses active during neurotransmission?” »

Most biology students will be able to tell you that neural signals are sent via mechanisms such as synaptic transmission, gap junctions, and diffusion processes, but a new study suggests there’s another way that our brains transmit information from one place to another.

Researchers in the US have recorded neural spikes travelling too slowly in the brain to be explained by conventional signalling mechanisms. In the absence of other plausible explanations, the scientists believe these brain waves are being transmitted by a weak electrical field, and they’ve been able to detect one of these in mice.

“Researchers have thought that the brain’s endogenous electrical fields are too weak to propagate wave transmission,” said Dominique Durand, a biomedical engineer at Case Western Reserve University. “But it appears the brain may be using the fields to communicate without synaptic transmissions, gap junctions or diffusion.”

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Headphones that stimulate the release of dopamine in your brain and reportedly make you feel high as hell have been invented by Florida-based tech company, Nervana, and are set to go on sale as early as next month.

The headphones will pump music into your ears as normal, but at the same time, an integrated device will deliver a low-power electrical signal through your ear canal to stimulate the Vagus nerve — a nerve that runs from the brainstem to the abdomen and plays a role in the release of dopamine, a neurotransmitter that helps control the brain’s reward and pleasure centres.

“I felt the electricity go into my arm, and everything was tingling there, but the best moment for me was afterwards when I finished and stood up,” journalist Amanda Gutterman writes for Futurism.

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The tiny injectable machine could turn your noodle into a remote control.

The Pentagon is attempting what was, until recently, an impossible technological feat—developing a high-bandwidth neural interface that would allow people to beam data from their minds to external devices and back.

That’s right—a brain modem. One that could allow a soldier to, for example, control a drone with his mind.

Continue reading “Pentagon Research Could Make ‘Brain Modem’ a Reality” »

People who play video games are geared (at least their brain is) for teleporting.

UC Davis researchers found that when people experienced virtual teleportation, their brains still managed to keep them on course.

African trypanosomiasis is called ‘sleeping sickness’ because when the infection is untreated, trypanosome parasites will invade the brain and cause disruption of sleeping patterns and irreversible neurological damage. A study published on February 25th in PLOS Pathogens reports that in a mouse model of trypanosome disease, nitric oxide (NO) plays an unexpected role in preserving the integrity of the blood brain barrier (BBB), thereby reducing parasite invasion into the brain, and likely limiting neurological damage.

NO is generally thought to be a pro-inflammatory signal, promoting a strong immune response against pathogens. The resulting inflammation is a mixed blessing: on one hand, it helps to control potentially dangerous pathogens, but on the other, it can cause “collateral damage” to the inflamed tissue.

Martin Rottenberg and colleagues, from the Karolinska Institute in Stockholm, Sweden, are interested in how trypanosome parasites cause disease and in the host immune defense against them. In this study, they examine the role of NO in a mouse model of trypanosomiasis, with a focus on how the parasites manage to get through the so-called blood brain barrier (BBB), the border surrounding the mammalian brain that is normally impenetrable to foreign intruders as well as most host cells.

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Interesting research and maybe a new twist for Dystonia.

Exactly what triggers dystonia — an involuntary muscle contraction of the hand, fingers, neck or mouth, which is sometimes very painful — is unclear. But some researchers think the underlying problem that causes it may also be the key to treating it, and other brain-linked disorders like Parkinson’s.

Fifteen miles away from where Larry Page and Sergey Brin worked out of their first office developing the technology that would become Google, a team of eleven engineers no older than 20 are hard at work on developing what they hope will be its replacement.

Their adoptive home, for the moment, is the co-working space Tim Draper set up as part of his Draper University startup program, and they’ve been assembled their by Jerry Yue, a 24-year-old serial entrepreneur.

Yue’s last startup, the Chinese food delivery service Benlai.com, raised $100 million at the end of last year and is on its way to joining the ranks of China’s unicorns.

Continue reading “Meet Brain, The AI Engine That Wants To Replace Search” »

Just Amazing

Ralph Mobbs, a neurosurgeon at the Prince of Wales Hospital in Sydney, made medical history in late 2015 when he successfully replaced two vertebrae with custom made prosthesis. The patient, in his 60s, suffered from Chordoma, a particularly nasty form of cancer that had formed on his top two vertebrae and threatened to cinch off his spinal cord as it grew. That would have left him a quadriplegic. Complicating matters, those top two vertebrae are what allow you to turn and tilt your head, so it’s not like doctors can easily fashion a replacement out of bone grafted from another part of the patient’s body. They have to fit perfectly and that’s where the 3D printers come in.

Mobbs worked with Anatomics, an Australian medical device manufacturer, to craft perfect replicas of the patient’s top two vertebrae out of titanium. This is the first time that these two particular neck bones have been printed and installed. “To be able to get the printed implant that you know will fit perfectly because you’ve already done the operation on a model … It was just a pure delight,” Mobbs told Mashable Australia. “It was as if someone had switched on a light and said ‘crikey, if this isn’t the future, well then I don’t know what is’.”

Continue reading “Doctors implant 3D-printed vertebrae in ‘world’s first’ surgery” »