Lifeboat Foundation

Scientists put their heads together for an insane medical breakthrough.

Neuroscience and biomedical engineering startup BrainBridge announced that it has created an AI-mechanized system for performing head transplants.

The procedure would graft a head onto the body of a brain-dead donor, maintaining the memories, cognitive abilities and consciousness of the transplanted individual.

New research has shown that frozen human brain tissue can be revived without damage.

Using a new approach, scientists have successfully frozen and thawed brain organoids and cubes of brain tissue from someone with epilepsy, which could enable better research into neurological conditions.

By Christa Lesté-Lasserre

Continue reading “Frozen human brain tissue can now be revived without damage” »

In a pioneering achievement, a research team led by experts at Cincinnati Children’s have developed the world’s first human mini-brain that incorporates a fully functional blood-brain barrier (BBB).

This major advance, published May 15, 2024, in Cell Stem Cell, promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer’s disease, Huntington disease, Parkinson’s disease, and other neurodegenerative conditions.

“Lack of an authentic human BBB model has been a major hurdle in studying neurological diseases,” says lead corresponding author Ziyuan Guo, PhD, “Our breakthrough involves the generation of human BBB organoids from human pluripotent stem cells, mimicking human neurovascular development to produce a faithful representation of the barrier in growing, functioning brain tissue. This is an important advance because animal models we currently use in research do not accurately reflect human brain development and BBB functionality.”

Summary: A new study finds that altered states of consciousness (ASCs), like those experienced during meditation, are more common than previously thought. 45% of respondents reported experiencing ASCs at least once, often leading to positive outcomes.

However, a significant minority also reported negative or even life-threatening suffering, highlighting the need for better support and understanding of these experiences.

The FDA has allowed billionaire Elon Musk’s Neuralink to implant its brain chip in a second person after it proposed a fix for a problem that occurred in its first patient. Correspondent Brooke Shafer joins \.

“Neuralink to implant 2nd human with brain chip as 85% of threads retract. Neuralink’s first patient, 29-year-old Noland Arbaugh, opened up about the roller-coaster experience. ” I was on such a high and then to be brought down that low. It was very, very hard,” Arbaugh said. ” I cried.” What a disaster!

Algorithm tweaks made up for the loss, and Neuralink thinks it has fix for next patient.

How do you define consciousness?

Some theories are even duking it out in a mano-a-mano test by imaging the brains of volunteers as they perform different tasks in clinical test centers across the globe.

But unlocking the neural basis of consciousness doesn’t have to be confrontational. Rather, theories can be integrated, wrote the authors, who were part of the Human Brain Project —a massive European endeavor to map and understand the brain—and specialize in decoding brain signals related to consciousness.

Continue reading “Scientists Are Working Towards a Unified Theory of Consciousness” »

A hormone already present in the human body could be used to stop Alzheimer’s disease in its tracks, scientists have announced.

Researchers discovered that a small part of an appetite-suppressing hormone called leptin, which is present in everyone, can have dramatic effects on the brain, including stopping the development of Alzheimer’s disease in its earliest stages.

Their tests have shown that leptin can reduce the effects of two toxic proteins in the brain called amyloid and tau, which build up and lead to memory loss and development of Alzheimer’s disease.

We acquired a rapidly preserved human surgical sample from the temporal lobe of the cerebral cortex. We stained a 1 mm³ volume with heavy metals, embedded it in resin, cut more than 5,000 slices at ∼30 nm and imaged these sections using a high-speed multibeam scanning electron microscope. We used computational methods to render the three-dimensional structure containing 57,216 cells, hundreds of millions of neurites and 133.7 million synaptic connections. The 1.4 petabyte electron microscopy volume, the segmented cells, cell parts, blood vessels, myelin, inhibitory and excitatory synapses, and 104 manually proofread cells are available to peruse online. Many interesting and unusual features were evident in this dataset. Glia outnumbered neurons 2:1 and oligodendrocytes were the most common cell type in the volume. Excitatory spiny neurons comprised 69% of the neuronal population, and excitatory synapses also were in the majority (76%). The synaptic drive onto spiny neurons was biased more strongly toward excitation (70%) than was the case for inhibitory interneurons (48%). Despite incompleteness of the automated segmentation caused by split and merge errors, we could automatically generate (and then validate) connections between most of the excitatory and inhibitory neuron types both within and between layers. In studying these neurons we found that deep layer excitatory cell types can be classified into new subsets, based on structural and connectivity differences, and that chandelier interneurons not only innervate excitatory neuron initial segments as previously described, but also each other’s initial segments. Furthermore, among the thousands of weak connections established on each neuron, there exist rarer highly powerful axonal inputs that establish multi-synaptic contacts (up to ∼20 synapses) with target neurons. Our analysis indicates that these strong inputs are specific, and allow small numbers of axons to have an outsized role in the activity of some of their postsynaptic partners.

The authors have declared no competing interest.