Scientists have discovered a new type of brain cell that promises to shake up the field of neuroscience.
The discovery brings an end to a decades-old controversy and may pave the way for new targeted treatments for a range of health conditions.
For now, cyborgs exist only in fiction, but the concept is becoming more plausible as science progresses. And now, researchers are reporting in ACS’ Nano Letters that they have developed a proof-of-concept technique to “tattoo” living cells and tissues with flexible arrays of gold nanodots and nanowires. With further refinement, this method could eventually be used to integrate smart devices with living tissue for biomedical applications, such as bionics and biosensing.
Advances in electronics have enabled manufacturers to make integrated circuits and sensors with nanoscale resolution. More recently, laser printing and other techniques have made it possible to assemble flexible devices that can mold to curved surfaces. But these processes often use harsh chemicals, high temperatures or pressure extremes that are incompatible with living cells. Other methods are too slow or have poor spatial resolution. To avoid these drawbacks, David Gracias, Luo Gu and colleagues wanted to develop a nontoxic, high-resolution, lithographic method to attach nanomaterials to living tissue and cells.
The team used nanoimprint lithography to print a pattern of nanoscale gold lines or dots on a polymer-coated silicon wafer. The polymer was then dissolved to free the gold nanoarray so it could be transferred to a thin piece of glass. Next, the gold was functionalized with cysteamine and covered with a hydrogel layer, which, when peeled away, removed the array from the glass. The patterned side of this flexible array/hydrogel layer was coated with gelatin and attached to individual live fibroblast cells. In the final step, the hydrogel was degraded to expose the gold pattern on the surface of the cells. The researchers used similar techniques to apply gold nanoarrays to sheets of fibroblasts or to rat brains. Experiments showed that the arrays were biocompatible and could guide cell orientation and migration.
The density of neurons in the brain is governed by a fundamental mathematical function, new research finds.
The discovery, which holds true across a variety of mammals, could help researchers make better computer models of the brain in the future.
The hyperactivity disorder, usually referred to as ADHD, is an independent risk factor for several common and serious mental health issues, finds research published in the open access journal BMJ Mental Health.
It is associated with major depression, post traumatic stress disorder, the eating disorder anorexia nervosa, and suicide attempts, the findings show, prompting the researchers to recommend vigilance by health professionals in a bid to ward off these disorders later on.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition in children and teens that extends into adulthood in up to around two thirds of cases. Worldwide, its prevalence is estimated to be around 5% in children/teens and 2.5% in adults.
In new research published in BMC Medicine, the authors recruited a large cohort of participants in order to assess how plant-based foods affect aging trajectories [1].
Previous research has shown that consumption of plant-based foods is associated with healthy aging [2,3]. It can also help to decrease the risk of mortality [4], prevent the development of chronic diseases [5,6], and improve neurological health, such as by lowering the risk of dementia [7] and cognitive impairment [8].
This new study aimed to determine the influence of a plant-based diet on the aging trajectory of the middle-aged Asian population. Researchers recruited over 10,000 people 50 years and older in Taiwan. Participants provided health data four times during the eight years after enrollment, underwent physical examinations, and filled out relevant questionnaires.
Lack of skills and training is a big issue. Some employees may simply not have the necessary skills or training to perform their tasks effectively. Investing in employee development can improve performance and solve lots of heartaches. Let us share Jenny’s story: Why Jenny’s Promotion Changed the Way We View Training: A Dive into Neuroscience “Guess who got the promotion?” Jenny burst in one Monday morning, her face beaming with a mix of surprise and elation. Most of us knew Jenny from her early days—an employee with lots of enthusiasm but, frankly, a bit lost in the intricacies of the industry.
Recently, we spoke to Shai Efrati MD, Chair of Aviv Clinics’ Medical Advisory Board and Founder and Director of the world-leading Sagol Center for Hyperbaric Medicine and Research, about the longevity and healthspan benefits of hyperbaric oxygen therapy (HBOT). The Aviv Medical Program is designed for individuals experiencing cognitive and physical decline because of a variety of conditions, including stroke, post-COVID and age-related cognitive decline, Aviv also has an increasing number of clients who wish to improve their cognitive and physical performance and increase their healthspan.
One of Aviv’s patients is Patti Finnegan, a senior living in The Villages in Florida, and we sat down with her to find out what HBOT entails for the patient.
Longevity. Technology: At Longevity. Technology, we often cover therapies and treatments that have been developed or launched, discussing the science behind them and the possible results for the patient. What is less common, however, is to hear from the patients themselves – how did they find the experience and has it made a difference? What starts in a test tube or a white board ends up in a person, so it is important to retain a focus on the end user; after all, while patient population data is important, improving outcomes for actual people is the key goal behind longevity science – real people living longer, healthier lives.
An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study published in Science Signaling led by researchers at New York University College of Dentistry.
Targeting this protein—the ORAI1 calcium channel —could provide a new approach to treating oral cancer, which causes persistent pain that worsens as it progresses.
“Our results show that the ORAI1 channel fuels the growth of oral cancer tumors and produces an abundance of molecules that, once secreted, interact with neurons resulting in an increased sensitivity to pain,” said Ga-Yeon Son, a postdoctoral fellow in the Department of Molecular Pathobiology at NYU College of Dentistry and the study’s first author.
As scientists get better at interpreting the language of the brain, they get closer to not just treating disease, but also enhancing our senses and our intellects. Should they go there?
