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As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles that can break down the physical barriers around tumors to reach cancer cells. Once inside, the nanoparticles release their payload: a gene editing system that alters DNA inside the tumor, blocking its growth and activating the immune system.

The new nanoparticles, described in Nature Nanotechnology, effectively stopped the growth and spread of ovarian and liver tumors in mice. The system offers a new path forward for the use of the gene editing tool known as CRISPR-Cas9 in cancer treatment, said study leader Daniel Siegwart, Ph.D., Associate Professor of Biochemistry at UT Southwestern.

“Although CRISPR offers a new approach for treating cancer, the technology has been severely hindered by the low efficiency of delivering payloads into tumors,” said Dr. Siegwart, a member of the Harold C. Simmons Comprehensive Cancer Center.

Foresight Molecular Machines Group.
Program & apply to join: https://foresight.org/molecular-machines/

John Randall.
Why the world is finally ready for Atomically Precise Manufacturing.

Continue reading “J. Randall & S. Kalinin | Ready for Atomically Precise Manufacturing & Electron Microscopy” »

For a few years now, spent grain, the cereal residue from breweries, has been reused in animal feed. This material could also be used in nanotechnology. Professor Federico Rosei’s team at the Institut national de la recherche scientifique (INRS) has shown that microbrewery waste can be used as a carbon source to synthesize quantum dots. The work, done in collaboration with Claudiane Ouellet-Plamondon of the École de technologie supérieure (ÉTS), was published in the Royal Society of Chemistry’s journal RSC Advances.

Often considered “artificial atoms,” quantum dots are used in the transmission of light. With a range of interesting physicochemical properties, this type of nanotechnology has been successfully used as a sensor in biomedicine or as LEDs in next generation displays. But there is a drawback. Current quantum dots are produced with heavy and toxic metals like cadmium. Carbon is an interesting alternative, both for its biocompatibility and its accessibility.

A group of scientists working on surface-enhanced Raman spectroscopy (SERS) has made a nanoruler to provide insight into the longitudinal plasmonic fields in nanocavities, according to research published in the Journal of the American Chemical Society.

SERS is a highly sensitive and powerful spectral analysis technique applicable in various fields. In contrast to weak Raman scattering, SERS achieves a dramatically enhanced Raman signal of up to 10^10–15, allowing the analysis of single molecules.

“How we develop the technology depends, to a large extent, on what we know about plasmonic fields. In the experiments, we observed an uneven distribution in the plasmonic field at the nano-scale. But it lacks theoretic and experimental support. So we decided to figure it out,” said Yang Liangbao, who leads the team at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.

Quantum computers are one of the key future technologies of the 21^st century. Researchers at Paderborn University, working under Professor Thomas Zentgraf and in cooperation with colleagues from the Australian National University and Singapore University of Technology and Design, have developed a new technology for manipulating light that can be used as a basis for future optical quantum computers. The results have now been published in Nature Photonics.

New optical elements for manipulating light will allow for more advanced applications in modern information technology, particularly in quantum computers. However, a major challenge that remains is non-reciprocal light propagation through nanostructured surfaces, where these surfaces have been manipulated at a tiny scale.

Professor Thomas Zentgraf, head of the working group for ultrafast nanophotonics at Paderborn University, explains that “in reciprocal propagation, light can take the same path forward and backward through a structure; however, non-reciprocal propagation is comparable to a one-way street where it can only spread out in one direction.”

An international team of researchers has demonstrated a technique that allows them to align gold nanorods using magnetic fields, while preserving the underlying optical properties of the gold nanorods.

“Gold nanorods are of interest because they can absorb and scatter specific wavelengths of light, making them attractive for use in applications such as biomedical imaging, sensors, and other technologies,” says Joe Tracy, corresponding author of a paper on the work and a professor of materials science and engineering at North Carolina State University.

It is possible to tune the wavelengths of light absorbed and scattered by engineering the dimensions of the gold nanorods. Magnetically controlling their orientation makes it possible to further control and modulate which wavelengths the nanorods respond to.

Cytoskeletons are essential components of cells that perform a variety of tasks, and artificial cytoskeletons that perform these functions are required for the bottom-up assembly of synthetic cells. Now, a multi-functional cytoskeleton mimic has been engineered from DNA, consisting of confined DNA filaments that are capable of reversible self-assembly and transport of gold nanoparticles and vesicular cargo.

Manufacturing with atoms has been the siren’s call for many researchers who believed it was the key that could unlock enormous new potential in how we build things. We could develop products that are perfectly precise, contain zero waste and that are 1000x more energy efficient. The problem has always been the same: How? Until now. Wolkow has taken a leading role in laying a new, stable foundation for the world to begin building on the tiniest of scales. Robert Wolkow is a Professor in the Department of Physics, iCORE Chair of Nanoscale Information and Communications Technology at the University of Alberta and Fellow of the Royal Society of Canada. He is also the Principal Research Officer and Nanoelectronics Program Coordinator at the NRC Nanotechnology Research Centre (NRC-NANO), AITF Industrial Chair in Atom Scale Fabrication and CTO of Quantum Silicon Inc.

An award-winning innovator, Wolkow has had a leading role in discovering, altering and deploying atom scale properties of silicon. His years of fundamental advances have laid a broad foundation for practical applications. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Developed in collaboration with colleagues from China, Germany and Singapore, the new technology uses nanoparticles, so small that about 12,000 of them can fit within a cross-section of a human hair. These tiny particles are arranged into unique patterns on the slides.

Physicists at The Australian National University (ANU) have developed tiny translucent slides capable of producing two very different images by manipulating the direction in which light travels through them.

As light passes through the slide, an image of Australia can be seen, but when you flip the slide and look again, an image of the Sydney Opera House is visible. The pair of images created is just one example of an untapped number of possibilities.

Continue reading “Nanoparticles that control flow of light like road signs direct traffic” »