The weekend is here so let’s kick it off with a great talk by Dr. Aubrey de Grey at TED in 2014.
Biotechnologist Aubrey de Grey talks about aging as a disease — and how it can be cured.
Continue reading “How to end aging: Aubrey de Grey at TEDxOxbridge” »
Nathaniel David from Unity Biotech giving a talk about the potential of Senolytics and how science can break the natural limit to lifespan. David is the CEO of Unity Biotechnology a company taking SENS based Senolytic drugs into human clinical trials in the next year or so. Very exciting as this is the first true rejuvenation biotechnology therapy to be deployed in humans.
Unity is leading the way for the first rejuvenation technologies in the #sens model. Here we have Nathaniel David from Unity talking about the potential of Senolytics and increased lifespans.
Continue reading “Drugs to Extend Life — Nathaniel David, CEO of Unity Biotechnology” »
A look back at one of the milestones for SRF and the first successful fundraiser on Lifespan.io for MitoSENS.
We need your support at this critical juncture of the MitoSENS project. The MitoSENS team has already demonstrated the rescue of cells containing mitochondrial mutations, and has recently generated highly promising preliminary data showing the rescue of the complete loss of a mitochondrial gene. Our next steps will focus on improving the effectiveness of the targeting system, so that we can repeat our success with one mitochondrial gene to all thirteen. We will then transition this work into animal models of mitochondrial dysfunction. This would be a crucial step in what may be the development of an eventual cure for aging and aging related diseases.
Vote for senolytics and help get aging research into public view.
Please VOTE NOW for senescent cell removal (The purge that refreshes) and help make aging research the science breakthrough of the year and get rejuvenation biotechnology into the public eye.
#aging #sens
Continue reading “Vote for your scientific breakthrough of the year!” »
Wearable fitness devices could help you with your personal longevity strategy.
NEW YORK — Activity monitors could improve our health and extend our lives — if only we could be motivated to use them. Those are the conclusions of two new studies about the promise and perils of relying on fitness trackers to measure and guide how we move.
The monitors, which are expected to be a popular holiday gift again this year, can generally track our steps, speed, stance (sitting or not), distance, energy expenditure and heart rate. The absolute accuracy of these numbers, however, is somewhat suspect, with past studies finding errors in many of the monitors’ measurements. But the inaccuracies are usually consistent, the studies show, so the trackers can reliably indicate how our movements change from day to day.
Continue reading “Fitness trackers might help us live longer” »
Fat tissue, immune dysfunction and cellular senescence are closely related. Here we have some commentary from Reason at Fightaging! once of our new Patron sponsors about some recent research liking these factors together.
“Cellular senescence is one of the root causes of aging, and there are at present serious, well-funded efforts underway to produce rejuvenation therapies based on the selective destruction of senescent cells in old tissues. This progress is welcome, but it could have started a long time ago. It has taken many years of advocacy and the shoestring production of technology demonstrations to finally convince the broader community of scientists and funding institutions that the evidence has long merited serious investment in treatments to clear senescent cells”.
#sens #aging
Continue reading “Linking Excess Fat Tissue, Immune Dysfunction, and Cellular Senescence in Aging” »
New technology driving down the cost of research and therapies!
New technology arriving that will help drive down the costs of gene therapies.
“The researchers were able to use a closed, semi-automated benchtop system to produce genetically-modified HSCs in just one night and hope that such systems will increase the availability and affordability of cell therapies”.
Led by Nikolay Kandul, senior postdoctoral scholar in biology and biological engineering in the laboratory of Professor of Biology Bruce Hay, the team developed a technique to remove mutated DNA from mitochondria, the small organelles that produce most of the chemical energy within a cell. A paper describing the research appears in the November 14 issue of Nature Communications. There are hundreds to thousands of mitochondria per cell, each of which carries its own small circular DNA genome, called mtDNA, the products of which are required for energy production. Because mtDNA has limited repair abilities, normal and mutant versions of mtDNA are often found in the same cell, a condition known as heteroplasmy.
Hitting the pause button on development in embryos has implications for understanding aging.
UC San Francisco researchers have found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with potential implications for assisted reproduction, regenerative medicine, aging, and even cancer, the authors say.
The new study—published online November 23, 2016 in Nature —involved experiments with pre-implantation mouse embryos, called blastocysts. The researchers found that drugs that inhibit the activity a master regulator of cell growth called mTOR can put these early embryos into a stable and reversible state of suspended animation.
Continue reading “Researchers put mouse embryos in suspended animation” »
Progress towards making a blood scrubber to calibrate the pro aging factors in blood. Irina Conboy has spent the last 20 years working on parabiosis and signalling factors in blood and this is yet another step forward for their research.
Whilst many are seeking the secret sauce in young blood the data suggests it is much more likely the case that old blood contains too many pro-aging factors eg, TGF-beta, TNF-a, IL-6, CD38 etc… The aim is now to filter old blood and calibrate such factors in order to promote a pro-youthful signalling environment. If only this device was small enough to wear or implant.
In what could be a fresh chapter in the never-ending story of the search for eternal youth, scientists are to tinker with people’s blood in the hope of slowing down the ageing process and preventing age-related diseases.
Continue reading “Scientists to ‘reset’ blood proteins in attempt to slow ageing process” »
