Lifeboat Foundation

The Methuselah Foundation wants to extend healthy life — By advancing tissue engineering and regenerative medicine, they want to create a world where 90-year olds can be as healthy as 50-year olds—by 2030.

Donate to the Methuselah Foundation here at this link

Methuselah Foundation reviewed the progress they made over the past year. Much of what you’ll read in this year in review letter is very late-breaking, and leads us to believe that 2017 will be a very important year in medical developments. 2016 took us a broad step closer to fulfilling our mission statement to “Make 90 the New 50, by 2030”. Why can we say that? For starters, let’s look at several achievements to date that made this year so successful:

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Restorative neuroscience, the study to identify means to replace damaged neurons and recover permanently lost mental or physical abilities, is a rapidly advancing scientific field considering our progressively aging society. Redirecting immature neurons that reside in specific brain areas towards the sites of brain damage is an appealing strategy for the therapy of acute brain injury or stroke. A collaborative effort between the Center for Brain Research of Medical University of Vienna and the National Brain Research Program of Hungary/Semmelweis University in Budapest revealed that some mature neurons are able to reconfigure their local microenvironment such that it becomes conducive for adult-born immature neurons to extensively migrate. Thus, a molecular principle emerges that can allow researchers to best mobilize resident cellular reserves in the adult brain and guide immature neurons to the sites of brain damage.

The adult brain has limited capacity of self-repair.

In the aging Western society, acute brain damage and chronic neurodegenerative conditions (e.g. Alzheimer’s and Parkinson’s diseases) are amongst the most debilitating diseases affecting hundreds of millions of people world-wide. Nerve cells are particularly sensitive to microenvironmental insults and their loss clearly manifests as neurological deficit. Since the innate ability of the adult human brain to regenerate is very poor and confined to its few specialized regions, a key question in present-day neurobiology is how to establish efficient strategies that can replace lost neurons, guide competent cells to the sites of injury and facilitate their functional integration to regain lost functionality. “Cell replacement therapy” thus offers frontline opportunities to design potent therapeutic interventions.

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Currently in human trials in the U.S.

Russian and Swedish scientists have used an artifical antioxidant to slow the aging process is lab mice. The compound, known as SkQ1, targets mitochondria. ROBERT F. BUKATY AP File.

We celebrate her birthday and life but what fun is there to living so long when aging takes its toll? Science is aiming to do better, find out how here!

Today, February 21, is the birthday of Jeanne Louise Calment – the oldest verified human being ever, who managed to live an amazing 122 years and 164 days!

Jeanne was an independent and positive person, and she managed to live all alone until aged 110. After a fire in her apartment she moved into a nursing home, but even there she was still able to take care of herself. However, shortly before her 115th birthday she fell down a stairway and never fully recovered her ability to walk.

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Our society has never aged more rapidly – one of the most visible symptoms of the changing demographics is the exponential increase in the incidence of age-related diseases, including cancer, cardiovascular diseases and osteoarthritis. Not only does aging have a negative effect on the quality of life among the elderly but it also causes a significant financial strain on both private and public sectors. As the proportion of older people is increasing so is health care spending. According to a WHO analysis, the annual number of new cancer cases is projected to rise to 17 million by 2020, and reach 27 million by 2030. Similar trends are clearly visible in other age-related diseases such as cardiovascular disease. Few effective treatments addressing these challenges are currently available and most of them focus on a single disease rather than adopting a more holistic approach to aging.

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Here’s my take on why the overpopulation objection to rejuvenation is morally unacceptable.

In this article, I’ll try to show that the overpopulation objection against rejuvenation is morally deplorable. For this purpose, whether or not the world is overpopulated or might be such in the future doesn’t matter. I’ll deal with facts and data in the two other articles dedicated to this objection; for now, all I want is getting to the conclusion that not developing rejuvenation for the sake of avoiding overpopulation is morally unacceptable (especially when considering the obvious and ethically more sound alternative), and thus overpopulation doesn’t constitute a valid objection to rejuvenation.

I’ll start with an example. Imagine there’s a family of two parents and three children. They’re not doing too well financially, and they live packed in a tiny apartment with no chances of moving somewhere larger. Clearly they cannot afford having more children, but they would really like having more anyway. What should they do?

The only reasonable answer is that they should not have any more children until they can afford having them. Throwing away the old ones for the sake of some other child to be even conceived yet would be nothing short of sheer madness.

Continue reading “Moral implications” »

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The Atlantic created this 5-minute video featuring #transhumanism and life extension work.

Some people are taking steps now to prepare for a life without death.

Church mentioned human trials in 2 years a few months ago. this is the first I have seen him say that in 10 years the reversal of aging will be a reality. That’ll make me 55. Hurry.

While discussing creating a hybrid elephant — wooly mammoth using CRISPR genome editing, Harvard’s George Church predicted that reversal of aging will be a reality within ten years.

Nextbigfuture suspects that this could mean clearly reversing aging in mice cells as a proof in principle in ten years. But evidence suggests Church does mean full and significant aging reversal in humans within ten years. In March of 2016 Church said, aging should be thought of as a program that might be reversed, noting, “If we could take one of my skin cells and turn it into an embryo-like cell and turn it back into a skin cell it has reset almost all of the developmental indications of age. We have 65 gene therapies that are being test in mice and larger animals. If they go well we will go straight into human trials. That could be as little as two years…

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