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“If you look at the brain chemically, it’s like a soup with a bunch of ingredients,” said Dr. Fan Lam.

Can we map the brain to show its behavior patterns when a patient is healthy and sick? This is what a recent study published in Nature Methods hopes to address as a team of researchers at the University of Illinois Urbana-Champaign used a $3 million grant obtained from the National Institute of Aging to develop a novel approach to mapping brain behavior when a patient is both healthy and sick. This study holds the potential to help researchers, medical professionals, and patients better understand how to treat diseases.

“If you look at the brain chemically, it’s like a soup with a bunch of ingredients,” said Dr. Fan Lam, who is an assistant professor of bioengineering at the University of Illinois Urbana-Champaign and a co-author on the study. “Understanding the biochemistry of the brain, how it organizes spatiotemporally, and how those chemical reactions support computing is critical to having a better idea of how the brain functions in health as well as during disease.”

Continue reading “3D Molecular Maps of the Brain: Unveiling Complexity with Spatial Omics” »

Scientists have revealed surprising parallels between aging and schizophrenia. There seem to be similar patterns of gene activity in the brains of people who are aging, and in those with schizophrenia. The same mechanisms may underlie the cognitive disruptions seen in older adults and people with schizophrenia. The findings have been reported in Nature.

In this work, the researchers analyzed gene expression at the single-cell level in post-mortem brain samples from 94 people with schizophrenia and 97 unaffected individuals. This gene activity was altered in two types of cells found in the brain, both neurons and astrocytes. In all, 1.2 million cells from were analyzed. This showed that in neurons, expression changed in genes that are associated with portions of synapses, the space where neurons meet and communicate; and in astrocytes, in genes that are related to synaptic function.

Too few babies — not — is likely to be a major problem this century.

Startup seeks new biomarkers as it develops cellular reprogramming drugs designed to reverse brain aging and combat dementia.

Researchers from the UoC’s Center for Biochemistry at the Faculty of Medicine and the UoC CECAD Cluster of Excellence in Aging Research have discovered that an excessive immune response can be prevented by the intramembrane protease RHBDL4.

In a study now published in Nature Communications under the title “RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling,” the previously unknown regulatory mechanism is described.

The researchers discovered that the cleavage of a cargo receptor by a so-called intramembrane protease reduces the localization of a central immune receptor on the cell surface and thereby the risk of an overreaction of the immune system.

Harvard longevity researcher David Sinclair recently made an astonishing assertion: Scientists had developed the first pill “proven to reverse aging” in dogs.

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The most popular words of 2023 were recently released, with AI Large Language Model (LLM) unquestionably topping the list. As a front-runner, ChatGPT also emerged as one of the international buzzwords of the year. These disruptive innovations in AI owe much to big data, which has played a pivotal role. Yet, AI has simultaneously presented new opportunities and challenges to the development of big data.

High-capacity data storage is indispensable in today’s digital economy. However, major storage devices like hard disk drives and semiconductor flash devices face limitations in terms of cost-effectiveness, durability, and longevity.

Optical data storage offers a promising green solution for cost-effective and long-term data storage. Nonetheless, optical data storage encounters a fundamental limitation in the spacing of adjacent recorded features, owing to the optical diffraction limit. This physical constraint not only impedes the further development of direct laser writing machines but also affects optical microscopy and storage technology.

Dialogues In Longevity With Dr. Aubrey de Grey, President & Chief Science Officer, Longevity Escape Velocity Foundation & Dr. Michael Rose, Director of the Network for Experimental Research on Evolution (NERE), and Professor, Department of Ecology and Evolutionary Biology, University of…