Lifeboat Foundation

Using computational models of individual brains could shed light on how brain stucture affects how we perform language-related tasks.

Today we have the transcript of “Pursuing Outreach Opportunities: Lifespan.io’s Experiences in Promoting Healthy Life Extension”, a talk that LEAF Outreach Director Elena Milova gave at TransVision 2018, a transhumanist conference in Madrid, Spain recently.

This is the transcript of “Pursuing Outreach Opportunities: Lifespan.io’s Experiences in Promoting Healthy Life Extension”, a talk that LEAF Outreach Director Elena Milova gave at TransVision 2018, a transhumanist conference in Madrid, Spain.

My name is Elena Milova, and I work with the Life Extension Advocacy Foundation, a non-profit organization headquartered in New York City. Our main activity is to support research on regenerative therapies that can possibly make human life healthier and longer. To do that, we have developed the non-profit crowdfunding platform Lifespan.io, and, as of now, we have gathered more than 300 thousand dollars in support of 7 scientific projects. We are currently running a campaign to support David Sinclair’s NAD+ Mouse project, a study of NMN and its effect on healthy lifespan in mice.

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Protein RbAp48 works with osteocalcin to preserve memory in old age.

In a recent open-access study, scientists at Columbia University have demonstrated that a protein known as RbAp48 crucially interacts with osteocalcin to help preserve memory. The protein, which is present in mice as well as people, declines with age, contributing to age-related memory loss [1].

Abstract

Continue reading “RbAp48 And Osteocalcin Play A Crucial Role In Age-related Memory Loss” »

http://lifeofafighter.com/cell-regeneration-with-ira-pastor-…dcast-138/

In this interview, Vera Gorbunova, Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center, talks about our current understanding of the mechanisms behind the longevity and genome stability of exceptionally long-lived mammals and how this knowledge could be used to create therapies to extend healthy human lifespan.

The interview was made by Steve Hill and Elena Milova, members of the board of Lifespan.io.

►This video is presented by LEAF. Please support us by becoming a “Lifespan Hero”: http://lifespan.io/hero

It seems that opposition against anti-aging medicine may be slowly starting to crumble. For example, Lifespan.io’s current crowdfunding campaign is going extremely well, and journalists begin to talk about senolytics in positive terms, without any predictions of doom and gloom resulting from these upcoming drugs. Make no mistake—the pro-aging trance is still alive and well; for each journalist who puts time and effort into actually understanding senolytics and the health benefits that they are expected to bring to older people, there’s probably five who show little to no knowledge of the subject and rage against unspecified “immortality” technology and related impending catastrophes. This should tell us something about the kind of understanding they have of what they criticize—or how badly they need a clickbait piece to bring in visitors.

Today, the pro-aging trance is something that only rejuvenation advocates are aware of and battle against, but maybe, fifty years from now, it will be an interesting phenomenon of the past for psychologists to figure out. Maybe, on the YouTube of 2068, there will be videos making fun of it in pretty much the same way that some people today make fun of the old belief that hysteria was caused by stray uteruses wandering around women’s bodies.

The pro-aging trance is rather interesting indeed, as people who are subject to it tend to commit fallacies that they would never commit in other contexts. A very good example of this is the objection to inequality of access: this reasoning assumes that rejuvenation would not be available to everyone who needs it, for economical, political, or whatever reasons; understandably, this is perceived as a profound injustice, which pushes a fair number of people to make a leap and conclude that the best way to avoid this injustice is to never develop rejuvenation to begin with.

Drugs that target multiple aging pathways at once significantly extend the healthspan and lifespan of nematodes.

In a paper published in Developmental Cell, scientists from Yale University have demonstrated how targeting multiple pathways related to aging with different drug combinations can slow aging down and extend healthy lifespan in C. elegans [1].

Abstract

Continue reading “Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan Of Nematodes” »

On the 23rd of this month, Dr. David Sinclair did an Ask Me Anything over at the Futurology subreddit in support of the NAD+ Mouse Project on Lifespan.io. There were a range of interesting questions from the community about his work in aging research, particularly the role of NAD+ in aging.

Dr. David A. Sinclair is a Professor in the Department of Genetics at Harvard Medical School and a co-joint Professor in the Department of Physiology and Pharmacology at the University of New South Wales. He is the co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging and a Senior Scholar of the Ellison Medical Foundation. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente; there, he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability.

More recently, he has been in the spotlight for his work with NAD+ precursors and their role in aging and has been helping to develop therapies that replace NAD+, which is lost with aging, in order to delay the diseases of old age. Below are a selection of questions and answers from the AMA, and we urge you to head over to Reddit Futurology to check out the other questions that people asked.

In addition, a small number of posters will be selected for oral presentation.

Poster topics should lie within the scope of the conference: Research contributing to the eventual postponement of age-related decline in health, with an emphasis on measures that repair damage rather than slowing its creation. Poster submissions are due on January 31, 2019.

To submit your poster go to:

Continue reading “The 2019 Undoing Aging Conference will again include poster sessions” »