Lifeboat Foundation

Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Est3, which are essential for in vivo telomerase function. Here we report the high-resolution structure of Est3 from Hansenula polymorpha (HpEst3) in solution, as well as the characterization of its functional relationships with other components of telomerase. The overall structure of HpEst3 is similar to that of Est3 from Saccharomyces cerevisiae and human TPP1. We have shown that telomerase activity in H. polymorpha relies on both Est3 and Est1 proteins in a functionally symmetrical manner. The absence of either Est3 or Est1 prevents formation of a stable ribonucleoprotein complex, weakens binding of a second protein to TER, and decreases the amount of cellular TERT, presumably due to the destabilization of telomerase RNP. NMR probing has shown no direct in vitro interactions of free Est3 either with the N-terminal domain of TERT or with DNA or RNA fragments mimicking the probable telomerase environment. Our findings corroborate the idea that telomerase possesses the evolutionarily variable functionality within the conservative structural context.

“Eat your vitamins” might be replaced with “ingest your ceramic nano-particles” in the future as space research is giving more weight to the idea that nanoscopic particles could help protect cells from common causes of damage.

Oxidative stress occurs in our bodies when cells lose the natural balance of electrons in the molecules that we are made of. This is a common and constant occurrence that is part of our metabolism but also plays a role in the aging process and several pathological conditions, such as heart failure, muscle atrophy and Parkinson’s disease.

The best advice for keeping your body in balance and avoiding oxidative stress is still to have a healthy diet and eat enough vitamins, but nanoparticles are showing promising results in keeping cells in shape.

Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL.

Keywords: Bee venom, Melittin, Melittin conjugates, Cancer management, Anti-cancer effects.

Cancer is one of the major ailment effecting humankind and remains as one of the leading causes of mortality worldwide. The current available data suggests that over 10 million new patients are diagnosed with the disease every year and over 6 million deaths are associated with it representing roughly 12% of worldwide deaths. Fifteen million new cancer cases are anticipated to be diagnosed in the year 2020 [1] which will potentially increase to over 20 million by 2025 [2] and more in years to come. It is also anticipated that the growth and aging of the population may increase the new cancer cases to 21.7 million with about 13 million cancer deaths by the year 2030 [3].

The Buck Institute for Research on Aging scientists behind the research found that female mice that were fed enough AKG to maintain a younger mouse’s blood levels of the compound lived eight to 20 percent longer than the control group, according to research published Tuesday in the journal Cell Metabolism. On top of that, male and female mice who ate AKG had better fur color, stronger grips, and improved gait compared to others.

There’s a long and bumpy road between a successful mouse experiment and any sort of clinical applications for humans, but scientists are encouraged because AKG is already considered safe for humans to take.

“The big thing about this is that its safety profile is so good,” Holly Brown-Borg, a University of North Carolina aging researcher who didn’t work on the study told Science Magazine. “It has potential and should be explored further, for sure.”

Cellular Aquaculture — Feed The World and Save the Oceans — Lou Cooperhouse, President & CEO, of BlueNalu, joins me on ideaXme (https://radioideaxme.com/) to discuss his company’s technologies to provide the world with healthy and safe cell-based seafood products, and support the sustainability and diversity of our oceans — #Ideaxme #StemCells #Aquaculture #Oceans #Fish #Sushi #Poke #Ceviche #SustainableDevelopment #Agriculture #Health #Wellness #RegenerativeMedicine #Biotech #Longevity #Aging #IraPastor #Bioquark #Regenerage ideaXme BlueNalu Rutgers University Rich Products Sumitomo Chemical: Group Companies of the Americas KBW Investments.

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Lou Cooperhouse, President and CEO of BlueNalu.

Continue reading “Feeding the World with Cellular Aquaculture: Food Security and Sustainability” »

Deploying “AI for Good” In The Life Sciences — Tom Lawry, National Director for Artificial Intelligence, Health & Life Sciences, Microsoft, joins me on ideaXme to discuss how they are deploying artificial intelligence “at scale”, across the major organizations responsible for delivery quality, next generation healthcare to millions of patients and customers — #Ideaxme #Microsoft #ArtificialIntelligence #MachineLearning #DeepLearning #Health #Healthcare #Wellness #Medicine #Pharmacy #Hospitals #Nursing #Insurance #Diagnostics #Data #Moonshots #Biotechnology #Longevity #LifeExtension #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme life sciences ambassador, interviews Tom Lawry, National Director for Artificial Intelligence — Health & Life Sciences at Microsoft.

Continue reading “Tom Lawry Talks of Machine Learning and Microsoft AI For Good in Healthcare” »

Worldwide, 800,000 people die annually due to suicide (1 every 40 seconds) — There are more than twice as many suicides as homicides — Suicide is now the 10th leading cause of death in the US, and the 2nd leading cause of death among individuals between ages of 10 and 34 — Dr. Christine Moutier, M.D., Chief Medical Officer, American Foundation for Suicide Prevention, joins me on ideaXme to discuss her organization’s work in suicide prevention science and impacting these disturbing trends — #Ideaxme #Suicide #Depression #MentalHealth #Psychiatry #Anxiety #Stress #Trauma #Coronavirus #Burnout #WellBeing #Resilience #Health #Wellness #Longevity #Aging #IraPastor #Bioquark #Regenerage National Institute of Mental Health National Academy of Medicine.

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Christine Moutier, MD, Chief Medical Officer, at the American Foundation for Suicide Prevention (AFSP).

Continue reading “Dr Christine Moutier talks of Mental Health Awareness, Suicide Prevention and Building Resilience” »

Actually, the predominant language of the website is English, but even me being bilingual, I felt more comfortable delivering the narrative in my native language.

In the video, I give a thorough overview of the content and organization of my website Transhumanplus.com. It has a huge amount of information, growing constantly, on the transhumanist movement, emerging technologies in general, and very specially, on the longevity, rejuvenation and life extension field.

Continue reading “Watch: This video is narrated in Spanish, my native language, but I added comprehensive subtitles in English” »

US$400 million for healthy aging and elder care.

Ira Pastor ideaXme life sciences ambassador interviews Shelley Lyford, President and Chief Executive Officer of West Health, the Gary and Mary West Foundation, and the West Health Institute.

Continue reading “Billionaires Pour US $400 Million into Initiatives to Help the Weak and Vulnerable” »