Lifeboat Foundation

Dr. John Torday, Ph.D. is an Investigator at The Lundquist Institute of Biomedical Innovation, a Professor of Pediatrics and Obstetrics/Gynecology, and Faculty, Evolutionary Medicine, at the David Geffen School of Medicine at UCLA, and Director of the Perinatal Research Training Program, the Guenther Laboratory for Cell-Molecular Biology, and Faculty in the Division of Neonatology, at Harbor-UCLA Medical Center.

Dr. Torday studies the cellular-molecular development of the lung and other visceral organs, and using the well-established principles of cell-cell communication as the basis for determining the patterns of physiologic development, his laboratory was the first to determine the complete repertoire of lung alveolar morphogenesis. This highly regulated structure offered the opportunity to trace the evolution of the lung from its unicellular origins forward, developmentally and phylogenetically. The lung is an algorithm for understanding the evolution of other physiologic properties, such as in the kidney, skin, liver, gut, and central nervous system. Such basic knowledge of the how and why of physiologic evolution is useful in the effective diagnosis and treatment of disease.

Continue reading “Dr. John S Torday — Lundquist Institute / UCLA — Aging And Disease As A Process Of Reverse Evolution” »

In the search for ways to effectively combat age-related human disease, the enzyme sirtuin 6 (Sirt6) has recently become a focus of biochemical research. A targeted activation of Sirt6 could prevent or mitigate such diseases, for example some types of cancer. In a paper for the journal Nature Chemical Biology, biochemists from the University of Bayreuth have now shown how the small molecule MDL-801 binds to the enzyme Sirt6 and influences its activity. These findings stand to aid the development of new drugs.

Some really cool advances happening in cancer detection with things like liquid biopsies from companies like Grail and Thrive:

It’s important to detect cancer early to maximize longevity and survival rates. Here are cancer screening tests for 6 deadly cancers.

Curiosity about how well our bodies are ageing has fuelled an industry around telomere length tests, but the much touted “biological clock” in our DNA isn’t what we thought.

Modifying brain cell activity can extend the lifespan of fruit flies while also preventing the damage characteristic of Alzheimer’s disease, finds a new study led by UCL researchers.

This is a detailed summary of plasma dilution and at 58:38 the future is explained where they will publish human results from 25 people, then start a company whose first order of business will be phase 3 trials with more people and placebo and hopefully funding. It appears you can pay to have the procedure. The hopeful start is this year in may.

Irina will present her recent findings on plasma dilution, showing that age-reversing effects, such as rejuvenating tissues in mice, can be achieved by.
diluting the blood plasma of old mice: Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.

Continue reading “Tissue Rejuvenation via Plasma Dilution | Irina Conboy, UC Berkeley” »

Join us for Dr. Matt Kaeberlein’s presentation. He is the Founding Director of the UW Healthy Aging and Longevity Research Institute, and founder and co-Director of the Dog Aging Project and a Professor of Laboratory Medicine and Pathology at the University of Washington (UW) School of Medicine, with Adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.

“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov.

Continue reading “Dr. Matt Kaeberlein: Targeting Biological Ageing — A New Paradigm for 21st Century Medicine” »

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging—and how the production of neurons can be reactivated.

A trio of researchers with ICAEV, Universidad Austral de Chile, and the University of Liverpool, respectively, have found suppressor genes linked to longevity and less cancer in two species of whales. In their paper published in the journal Proceedings of the Royal Society B, Daniela Tejada-Martinez, João Pedro de Magalhães and Juan C. Opazo, describe their genetic study of longevity in cetaceans and what they learned.