Lifeboat Foundation

A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.

The immune system fights bacteria, viruses and other pathogens by utilizing several types of T cells, all of which have receptors that are specific to particular antigens. On killer T cells, the receptor works in concert with three signaling modules and a coreceptor to destroy the infected cell. Michael Kuhns, Ph.D., an associate professor in the UArizona College of Medicine—Tucson Department of Immunobiology, copied the evolutionary design to engineer a five-module chimeric antigen receptor, or 5MCAR, T cell.

“The 5MCAR was an attempt to figure out if we could build something by biomimicry, using some of evolution’s natural pieces, and redirect T cells to do what we want them to do. We engineered a 5MCAR that would direct killer T cells to target autoimmune T cells that mediate Type 1 diabetes,” said Dr. Kuhns, who is member of the UArizona Cancer Center, BIO5 Institute and Arizona Center on Aging. “So now, a killer T cell will actually recognize another T cell. We flipped T cell-mediated immunity on its head.”

Here the video of the first discussion panel out of two, during the celebration of the Healthy Masters Conference 2020, which took place on November 29, 2020. Nuno Martins, organizer and moderator of the event, asked all panelists to comment on the following theme: What can we do to improve our health and longevity. Given the essence of the event, the question was surrounded by the objective of achieving radical life extension or super longevity. My intervention starts at minute 20:13 and in the description of the video there are all the time marks that direct to the begining of each talk.

First discussion panel out of two, during the celebration of the Healthy Masters Conference 2020 which took place on November 29, 2020.
Nuno Martins, PhD, organizer and moderator of the event, asked all panelists to comment on the following theme: What can we do to improve our health and longevity?
Given the essence of the event, the question was surrounded by the objective of achieving radical life extension or super longevity.

Continue reading “Panelists at the Healthy Masters 2020 on What Can We Do to Improve Health and Longevity” »

It is the weekend and time for a new video… following on from last week, this time I am looking at the types of cardiovascular training and how they effect your body at the cellular level, so you can craft your own training program, suited to your lifestyle and preferences, that helps you slow the aging process so you can live long enough to live forever…and be fit enough to enjoy it to the maximum.

After all, if life is boring, why live forever?

Continue reading “The Benefits Of Cardiovascular Fitness — Live Long Enough To Live Forever” »

Join us on #FacebookLive for Thu, Dec 17.

Interested.

WASHINGTON (SBG) — Researchers studying cognitive deficits following traumatic brain injuries have discovered what they say is a revolutionary drug that could provide the cure for aging. The study by the University of California San Francisco has shown promising results among mice, essentially reversing age-related declines in memory. “We went on with this crazy experiment… and were able to return their cognitive function to as if they were never injured,” said Dr.

THE CRYONICS INSTITUTE NEWSLETTER ISSUE 03, 2020 https://www.cryonics.org/images/uploads/magazines/CI_NEWS_2020-03.pdf

Have you ever wondered why our bodies react as they do to stresses?

In this quick guide, I go right back to the primordial soup so to speak, and trace the factors that led to where we are today, and I finish off by looking at good and bad stresses so you can understand them, and use them to your advantage to stay fit and healthy, and even, maybe, to help you slow down aging…whilst we wait for the medical breakthroughs that will allow us to role back the years…

Continue reading “Using Stress To Your Advantage” »

Might want to dig deeper.

Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth).

Telomeres act as protective caps at the end of chromosomes to prevent them from replication errors during cell divisions. Every time a chromosome replicates itself, telomeres shorten. When the telomeres become too short, the cell can no longer replicate its chromosomes safely and becomes arrested, or senescent. That shortening has been linked to the aging process and development of degenerative diseases.

Continue reading “Aging, diet-induced obesity, and metabolic disease link explored in new research” »

Here’s my latest video about arguably the most debated biomarker, LDL!

LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 — 140, not 50 — 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.