Lifeboat Foundation

Voyager 1 is the farthest human-made object from Earth. After sweeping by Jupiter, Saturn, Uranus and Neptune, it is now almost 15 billion miles (24 billion kilometers) from Earth in interstellar space. Both Voyager 1 and its twin, Voyager 2, carry little pieces of humanity in the form of their Golden Records. These messages in a bottle include spoken greetings in 55 languages, sounds and images from nature, an album of recordings and images from numerous cultures, and a written message of welcome from Jimmy Carter, who was U.S. president when the spacecraft left Earth in 1977.

The Golden Records were built to last a billion years in the environment of space, but in a recent analysis of the paths and perils these explorers may face, astronomers calculated that they could exist for trillions of years without coming remotely close to any stars.

Having spent my career in the field of religion and science, I’ve thought a lot about how spiritual ideas intersect with technological achievements. The incredible longevity of the Voyager spacecraft presents a uniquely tangible entry point into exploring ideas of immortality.

The field of female reproductive longevity and inequality is getting more and more attention. In fact, it is one of the hottest areas of the emerging longevity biotechnology industry, and every venture firm in the field is either investing, incubating, or looking for projects in this area. Companies like BOLD Capital, Future Ventures, LongeVC, and iconic biotechnology investors including Bob Nelsen and Christian Angermayer, are all active and significant partners in this area of science. While females generally live longer than men, their reproductive period is limited—something that is often overlooked. A female’s peak reproductive years are between the late teens and late 20s. Fertility starts to decline by age 30, and this decline becomes more rapid once women reach the mid-30s. By 45, fertility declines so much that getting pregnant naturally is unlikely for most women. Likewise, women begin life with a fixed number of eggs in their ovaries, usually around one million. This number decreases as women age. Ovaries age faster than the rest of a woman’s body—an understudied phenomenon of a neglected organ. None of us would be here without them. Yet surprisingly little is known about the avocado-shaped organ that’s nestled inside half of all humans.

The ovaries also influence a woman’s overall health and well-being. This includes how they age, since this organ tends to lose its function with age faster than any other tissue. This is called asynchronous aging, and it’s one reason why a woman’s fertility declines, and menopause strikes, while they are still relatively young.

In one of my previous articles, I wrote about Gameto, a biotechnology company that is translating the impact of ovarian aging to develop solutions to improve fertility and stop the impact of menopause on female health. Gameto’s co-founder and CEO Dina Radenkovic told me about her intention to redefine the narrative around female reproductive longevity and making it more around health and longevity. Gameto is building a platform for ovarian therapeutics to address menopause and improve assisted fertility. Dina told me she hopes it will make women suffer fewer health problems in their later lives. Neglecting the ovaries—except for their crucial role in IVF treatments—has been part of a general disregard for many aspects of women’s health in the biomedical world.

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Levine’s Biological age calculator is embedded as an Excel file in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Continue reading “Quantifying Biological Age: Blood Test #3 in 2022” »

In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. George Church, Professor of Genetics at Harvard Medical School. Tune in as Dr. George Church discusses the many roles of gene therapy, including its ability to reverse age-related diseases.

For science-backed ways to live a healthier, longer life, download InsideTracker’s InnerAge eBook at insidetracker.com/podcast.

Continue reading “Dr. George Church—Gene Therapy and Aging” »

Summary: Researchers used optogenetics techniques to stimulate specific brain areas to increase neurogenesis and the production of neural stem cells to improve memory, cognition, and emotional processing in animal models.

Source: UNC Health Care.

We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer’s and Parkinson’s, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience. One way to push back against cognitive decline and anxiety would be to spur the creation of new neurons.

Circa 2014

As a seventh grader, I was lucky to land the job of ball boy for the Brooklyn Dodgers during their annual late-March exhibition games in Miami. The experience left me with fond memories — of Roy Campanella smoking a cigar as he stroked line drives in the batting cage, of a young Sandy Koufax throwing harder than seemed humanly possible and of an aging Jackie Robinson struggling to remain in the lineup.

Oddly, however, my most vivid memory is of the Dodgers’ longtime batboy as he sat in the locker room producing autographed baseballs. He’d twist his hand at odd angles as he scrawled replicas of the signatures of Duke Snider, Pee Wee Reese and other Dodger legends. To my untrained eye, the balls he inscribed were indistinguishable from those signed by the players themselves.

Continue reading “When Diamonds Are Dirt Cheap, Will They Still Dazzle?” »

Hey it’s Han from WrySci-HX going over the breakthroughs of scientists rejuvenating skin cells of middle aged donors by several decades, overcoming complete paralysis in just one day, and more! See below ↓↓↓

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Continue reading “Scientists Reverse Aging in Skin up to 40 Years! (May 2022 Science Update)” »

Summary: Supplementing a diet with Ascidiacea, or sea squirts, reversed some of the main signs of aging in mouse models.

Source: Xi’an jiaotong-Liverpool University.

If you have ever looked in the mirror and seen graying hair and wrinkles or forgotten the name of a close friend, you’d be forgiven for wishing for a pill that could slow or even reverse the effects of aging.